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P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals

Autor: David Back, Saye Khoo, Philippa Newton, Ian S. Williams, E. R. Meaden, Patrick G. Hoggard, D. Aldam, John Tjia, David Cornforth, J Lloyd

Publikováno v: Journal of Antimicrobial Chemotherapy. 50:583-588

Objectives: Efflux transporters may play a role in lowering intracellular drug concentrations. As the HIV protease inhibitors are substrates for the efflux transporters P-glycoprotein and MRP, we wished to investigate whether differences in expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9204008d465f9b8588be58bd021957
https://doi.org/10.1093/jac/dkf161

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Determination of P-gp and MRP1 expression and function in peripheral blood mononuclear cells in vivo

Autor: David Back, Patrick G. Hoggard, Saye Khoo, E. R. Meaden

Publikováno v: Journal of Immunological Methods. 262:159-165

P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) mediate the efflux of many therapeutic agents and have been implicated in the treatment failure of many infectious diseases and cancers. The ability to characterise the expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2a74dd1b6fb2e0dc314ba38c15156e
https://doi.org/10.1016/s0022-1759(02)00020-0

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Short Communication:Expression of P-Glycoprotein and Multidrug Resistance-Associated Protein in Healthy Volunteers and HIV-Infected Patients

Autor: B Maher, David Back, E. R. Meaden, Saye Khoo, Patrick G. Hoggard

Publikováno v: AIDS Research and Human Retroviruses. 17:1329-1332

Increased expression of the multidrug efflux transporters P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) has been suggested as a potential mechanism for decreased drug availability at certain intracellular sites that provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a58b59a4358a4cd7a33e3291b324a2a
https://doi.org/10.1089/08892220152596588

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P-glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?

Autor: Ross A. Davey, Patrick G. Bray, Saye Khoo, David Back, Stephen A. Ward, Kevin E. Jones, E. R. Meaden

Publikováno v: AIDS. 15:1353-1358

Background: The multidrug transporters P-glycoprotein (P-gp) and MRP1 are functionally expressed in several subclasses of lymphocytes. HIV-1 protease inhibitors interact with both; consequently the transporters could reduce the local concentration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238996ee18bdd61106c1fa736630ffb9
https://doi.org/10.1097/00002030-200107270-00004

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Effect of protease inhibitor-containing regimens on lymphocyte multidrug resistance transporter expression

Autor: Saye Khoo, Mark Dalton, J. Ford, E. R. Meaden, Philippa Newton, Ian S. Williams, David Back, Patrick G. Hoggard

Publikováno v: The Journal of antimicrobial chemotherapy. 52(3)

BACKGROUND: Increased expression of multidrug resistance transporters, such as P-glycoprotein (P-gp), has been suggested as a potential mechanism for decreased protease inhibitor (PI) availability at certain intracellular sites and tissue compartment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f1cd9319a1dcdaa8fd523c50f692e6
https://pubmed.ncbi.nlm.nih.gov/12917239

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