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Effect of recombinant human interferon α B/D (rHu-IFN-α B/D) in combination with acyclovir in experimental HSV-1 encephalitis

Autor: Richard J. Whitley, J.D. Gangemi, U. Wintergerst, S. Chatterjee, E. R. Kern

Publikováno v: Antiviral Research. 44:75-78

The efficacy of recombinant human interferon alpha B/D in experimental HSV-1 encephalitis was investigated in the murine system. Recombinant Hu-IFN-alpha B/D significantly reduced the mortality in a mouse encephalitis model (about 30%, P = 0.021), wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1686b1c6571269c2452602cbc18b2b
https://doi.org/10.1016/s0166-3542(99)00055-8

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Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus

Autor: John D. Mountz, E R Kern, Martin Fleck, C K Edwards rd, J Podlech, Winfried Wintersberger, Tong Zhou

Publikováno v: Journal of Clinical Investigation. 102:1431-1443

The role of Fas- and TNF-receptor 1 (TNF-R1)-mediated apoptosis in the clearance of virally infected cells and in the regulation of the immune response was analyzed after murine cytomegalovirus (MCMV) infection of C57BL/6 (B6)-+/+ mice, Fas-mutant B6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd543b9e6d80df244d2be1a8c580d314
https://doi.org/10.1172/jci3248

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Summary of the II International Symposium on Cytomegalovirus

Autor: George J. Galasso, Douglas A. Jabs, Brian Gazzard, M.D. de Jong, Stephen A. Spector, Paul D. Griffiths, E. R. Kern

Publikováno v: Antiviral research. 39(3):141-162

Human cytomegalovirus (HCMV) is a highly species-specific DNA virus belonging to the Betaherpesvirinae subfamily of the herpesviridae family. Like other herpesviruses, primary infection with HCMV is followed by persistence of the virus in a latent fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48a6a9cf0909435b3d9f7546fddb49c
https://doi.org/10.1016/s0166-3542(98)00044-8

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Differential effect of recombinant human and mouse interferons on replication of herpes simplex virus type 1 in mouse cells

Autor: Richard J. Whitley, S. Chatterjee, E. R. Kern, U. Wintergerst, J.D. Gangemi

Publikováno v: Antiviral Research. 32:27-34

Pretreatment of murine (BALB/3T3) cells with either murine or recombinant hybrid human B/D interferon (IFN) blocked the release of infectious herpes simplex virus type 1 (HSV-1) from treated cells. The block in replication was not due to an effect on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28d24d6e6a8ba8b5cf69c9cbd991bf3
https://doi.org/10.1016/0166-3542(95)00975-2

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Preclinical Evaluation of a Genetically Engineered Herpes Simplex Virus Expressing Interleukin-12

Autor: James J. Cody, E. R. Kern, George Yancey Gillespie, Jennifer M. Coleman, S. C. Cartner, Richard J. Whitley, Debra C. Quenelle, Trenton R. Schoeb, Kathleen H. Price, Parker Jn, Cheryl A. Palmer, James M. Markert, Alfred D. Lakeman

Herpes simplex virus 1 (HSV-1) mutants that lack the γ 1 34.5 gene are unable to replicate in the central nervous system but maintain replication competence in dividing cell populations, such as those found in brain tumors. We have previously demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2beeb8eb03bc2cf0b803716dae085a
https://europepmc.org/articles/PMC3347348/

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ChemInform Abstract: Arabinofuranosylpyrrolo(2,3-d)pyrimidines as Potential Agents for Human Cytomegalovirus Infections

Autor: Steven H. Krawczyk, Leroy B. Townsend, John C. Drach, M. Bernier‐Rodriguez, E. R. Kern, Linda L. Wotring, M. R. Nassiri

Publikováno v: ChemInform. 22

Protection of the 3'- and 5'-hydroxyl groups of the nucleoside antibiotic toyocamycin (1) with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane was followed by (trifluoromethyl)sulfonylation of the 2'-hydroxyl group. A displacement of the resulting trif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::725d2b2510b832f3bedfcf1317e9e699
https://doi.org/10.1002/chin.199118279

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