Zobrazeno 1 - 10
of 21
pro vyhledávání: '"E R, Fearon"'
Autor:
J M, Nigro, K R, Cho, E R, Fearon, S E, Kern, J M, Ruppert, J D, Oliner, K W, Kinzler, B, Vogelstein
Publikováno v:
Cell. 64:607-613
Using a sensitive assay for RNA expression, we identified several abnormally spliced transcripts in which exons from a candidate tumor suppressor gene (DCC) were scrambled during the splicing process in vivo. Cloning and sequencing of PCR-amplified s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dd8aa2114f25eac347d3953a5871f6
https://doi.org/10.1016/0092-8674(91)90244-s
https://doi.org/10.1016/0092-8674(91)90244-s
Publikováno v:
Cancer research. 61(22)
Clinical and molecular findings suggest that the four major histological subtypes of ovarian carcinoma (serous, clear cell, mucinous, and endometrioid) likely represent distinct disease entities. Prior studies have shown that ovarian endometrioid ade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e48062818ff915e02a1f7efbf9032cc
https://pubmed.ncbi.nlm.nih.gov/11719457
https://pubmed.ncbi.nlm.nih.gov/11719457
Publikováno v:
Genes, chromosomescancer. 30(3)
Constitutive activation of the Wnt signaling pathway as a result of genetic alterations of APC, AXIN1, and CTNNB1 has been found in various human cancers, including those of the colon, liver, endometrium, ovary, prostate, and stomach. To investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce12bed9d546caca21154d49406f46f1
https://pubmed.ncbi.nlm.nih.gov/11170292
https://pubmed.ncbi.nlm.nih.gov/11170292
Publikováno v:
Genesdevelopment. 14(11)
beta-Catenin and gamma-catenin (plakoglobin), vertebrate homologs of Drosophila armadillo, function in cell adhesion and the Wnt signaling pathway. In colon and other cancers, mutations in the APC tumor suppressor protein or beta-catenin's amino term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bb7fd1af9ab830717636b442346c6de
https://pubmed.ncbi.nlm.nih.gov/10837025
https://pubmed.ncbi.nlm.nih.gov/10837025
Publikováno v:
Genes, chromosomescancer. 27(4)
Loss of heterozygosity (LOH) of chromosome arm 18q is frequent in gastrointestinal cancers. Over 90% of pancreatic carcinomas have 18q LOH. Bi-allelic inactivation of the MADH4/DPC4/SMAD4 gene at 18q21.1 is seen in about half of pancreatic carcinomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a661ca57c1c0d71eb86a2ec0ac8a54ea
https://pubmed.ncbi.nlm.nih.gov/10719364
https://pubmed.ncbi.nlm.nih.gov/10719364
Autor:
K, Caca, F T, Kolligs, X, Ji, M, Hayes, J, Qian, A, Yahanda, D L, Rimm, J, Costa, E R, Fearon
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(6)
Adenomatous polyposis coli (APC) mutations are present in70% of colon cancers. The APC protein binds to beta-catenin (beta-cat), a protein first identified because of its role in E-cadherin (E-cad) cell adhesion. In some colon cancers lacking APC def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b858dfe2afb0ec117a524cd54788f5ce
https://pubmed.ncbi.nlm.nih.gov/10392898
https://pubmed.ncbi.nlm.nih.gov/10392898
Autor:
J A, Meyerhardt, K, Caca, B C, Eckstrand, G, Hu, C, Lengauer, S, Banavali, A T, Look, E R, Fearon
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(1)
Netrins, a family of laminin-related secreted proteins, have critical roles in axon guidance and cell migration during development. The deleted in colorectal cancer (DCC) protein has been implicated as a netrin-1 receptor component. The expression an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b3f3a6d77b4b7a7adb67f41d9733a15
https://pubmed.ncbi.nlm.nih.gov/9950216
https://pubmed.ncbi.nlm.nih.gov/9950216
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(7)
Decreased expression of E-cadherin (E-cad), a calcium-dependent cell adhesion molecule, has been seen in many different epithelial cancers. Although somatic mutations in the E-cad gene have been identified in a small subset of tumors, in the majority
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::037f28ebb40c11cf75cf0096eb273924
https://pubmed.ncbi.nlm.nih.gov/9218871
https://pubmed.ncbi.nlm.nih.gov/9218871
Publikováno v:
Oncogene. 11(11)
The DCC (deleted in colorectal cancer) candidate tumor suppressor gene spans greater than 1350 kilobases at chromosomes 18q21.1 and encodes a transmembrane protein of unknown function. Although DCC is expressed in a number of adult tissues, its expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f512f72bcaa187a463ba953f24814e3
https://pubmed.ncbi.nlm.nih.gov/8570191
https://pubmed.ncbi.nlm.nih.gov/8570191
Publikováno v:
Oncogene. 11(7)
Alterations in intercellular junction and membrane cytoskeletal proteins may underlie some of the morphological, invasive and metastatic properties of cancer. E-cadherin, a transmembrane protein that functions in epithelial cell-cell interactions at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f234de3c3faf769ddd61956393f17fb
https://pubmed.ncbi.nlm.nih.gov/7478552
https://pubmed.ncbi.nlm.nih.gov/7478552