Výsledky vyhledávání - "E R, DeSombre"

Radiotoxicity of Auger electron-emitting estrogens in MCF-7 spheroids: a potential treatment for estrogen receptor-positive tumors

Autor: T, Kearney, A, Hughes, R N, Hanson, E R, DeSombre

Publikováno v: Radiation research. 151(5)

To approach treatment of micrometastases of steroid receptor-rich cancers using estrogen receptor-directed therapy with Auger electrons, multicellular spheroids of the estrogen receptor-rich human breast cancer cell line, MCF-7, were prepared and exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb0e0fc0fac133b07cc69e0b8696aaac
https://pubmed.ncbi.nlm.nih.gov/10319730

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DNA and chromosome breaks induced by {sup 123}I-estrogen in CHO cells

Autor: R. Mustafi, J. L. Schwartz, A. Hughes, E R DeSombre

The effects of the Auger electron-emitting isotope I-123, covalently bound to estrogen, on DNA single- and double-strand breakage and on chromosome breakage was determined in estrogen positive Chinese hamster ovary (CHO-ER) cells. Exposure to the {su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::522df2a744f3882385c1b03747ef03d9
https://doi.org/10.2172/505324

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DNA and chromosome breaks induced by iodine-123-labeled estrogen in Chinese hamster ovary cells

Autor: J L, Schwartz, R, Mustafi, A, Hughes, E R, DeSombre

Publikováno v: Radiation research. 146(2)

The effects of the Auger electron-emitting isotope 123I, covalently bound to estrogen, on DNA single- and double-strand breakage and on chromosome breakage was determined in estrogen receptor-positive Chinese hamster ovary (CHO-ER) cells. Exposure to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eceab7b3396bd7f305be3507fb8e8f74
https://pubmed.ncbi.nlm.nih.gov/8693065

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Immunohistochemical localization of the oestrogen-responsive 110 kDa and 74 kDa polypeptides and complement component C3 in the rat genital tract after oestrogen treatment and during the oestrous cycle

Autor: E. R. DeSombre, L. A. Puy, P. C. Kuivanen

Publikováno v: Journal of reproduction and fertility. 99(2)

In previous studies we showed that two oestrogen-responsive rat uterine secretory polypeptides of molecular mass 110 and 74 kDa share sequence similarities with the alpha and beta chains of rat complement component C3. Using polyclonal antibodies spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeceea1e4501fda20b041470c8100331
https://pubmed.ncbi.nlm.nih.gov/8107020

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Comparison of the distribution of radioiodinated-E-17 alpha-iodovinyl-11 beta-methoxyestradiol and 2-iodo-1,1-bis(4-hydroxyphenyl)-phenylethylene estrogens in the immature female rat

Autor: A, Hughes, S J, Gatley, E R, DeSombre

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 34(2)

Current therapies for estrogen receptor-positive (ER+) cancers rely heavily on growth prevention by cytostatic agents rather than destruction of the cancer cells. In these studies, we compared the tissue distribution of two radioiodinated estrogens,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::259316dc2a3db804d761861162e45e2c
https://pubmed.ncbi.nlm.nih.gov/8429347

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Estrogen receptor-directed radiotoxicity with Auger electrons: specificity and mean lethal dose

Autor: E R, DeSombre, B, Shafii, R N, Hanson, P C, Kuivanen, A, Hughes

Publikováno v: Cancer research. 52(20)

To assess the feasibility of using estrogen receptor-directed therapy with Auger electron-emitting ligands for therapy of estrogen receptor (ER)-containing cancers, we synthesized and evaluated the radiotoxicity of several 123I-labeled estrogens to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f3fab78de22f03a784a68e900b795b4
https://pubmed.ncbi.nlm.nih.gov/1394199

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Comparison of the distribution of bromine-77-bromovinyl steroidal and triphenylethylene estrogens in the immature rat

Autor: E R, DeSombre, A, Hughes, R C, Mease, P V, Harper

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 31(9)

The specific uptake and distribution of steroidal and non-steroidal [77Br]bromovinylestrogens were studied in immature female rats to assess the potential of these radioligands for imaging or therapy of estrogen receptor (ER) positive cancers. E-17 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bce18ab999c208ebd22e7ef22cdd212f
https://pubmed.ncbi.nlm.nih.gov/2395021

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