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Association of location of BRCA1 and BRCA2 mutations with benefit from olaparib and bevacizumab maintenance in high-grade ovarian cancer:phase III PAOLA-1/ENGOT-ov25 trial subgroup exploratory analysis

Autor: S I, Labidi-Galy, M, Rodrigues, J L, Sandoval, J E, Kurtz, F, Heitz, A M, Mosconi, I, Romero, U, Denison, S, Nagao, I, Vergote, G, Parma, T J, Nøttrup, E, Rouleau, G, Garnier, A, El-Balat, C, Zamagni, C, Martín-Lorente, E, Pujade-Lauraine, A, Fiévet, I L, Ray-Coquard

Publikováno v: Labidi-Galy, S I, Rodrigues, M, Sandoval, J L, Kurtz, J E, Heitz, F, Mosconi, A M, Romero, I, Denison, U, Nagao, S, Vergote, I, Parma, G, Nøttrup, T J, Rouleau, E, Garnier, G, El-Balat, A, Zamagni, C, Martín-Lorente, C, Pujade-Lauraine, E, Fiévet, A & Ray-Coquard, I L 2023, ' Association of location of BRCA1 and BRCA2 mutations with benefit from olaparib and bevacizumab maintenance in high-grade ovarian cancer : phase III PAOLA-1/ENGOT-ov25 trial subgroup exploratory analysis ', Annals of Oncology, vol. 34, no. 2, pp. 152-162 . https://doi.org/10.1016/j.annonc.2022.11.003

BACKGROUND: In the phase III PAOLA-1 study, the addition of maintenance olaparib to bevacizumab in patients with newly diagnosed high-grade ovarian cancer (HGOC) resulted in prolonged progression-free survival (PFS), particularly for homologous recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7238bd7941a935684f35290251f1a332
https://curis.ku.dk/ws/files/338357926/1_s2.0_S0923753422047330_main.pdf

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579P A multicenter evaluation of a low pass whole genome sequencing-based solution for homologous recombination deficiency detection

Autor: A. Buisson, P. Saintigny, E. Pujade-Lauraine, C. Montoto Grillot, D. Varcica, M. Barberis, N. Colombo, A. Harlé, P. Gilson, C. Roma, F. Bergantino, P. Harter, S. Pignata, A.J. Gonzalez Martin, C. Schauer, K. Fujiwara, I.B. Vergote, T.J. Juhler-Nottrup, P-A. Just, I.L. Ray-Coquard

Publikováno v: Annals of Oncology. 33:S811-S812

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5325a7ec61b9106b93ea382600519099
https://doi.org/10.1016/j.annonc.2022.07.707