Výsledky vyhledávání - "E O, Aboagye"

Autor: D, Brickute, A, Beckley, L, Allott, M, Braga, C, Barnes, K J, Thorley, E O, Aboagye

Publikováno v: RSC advances. 11(20)

The squaryl moiety has emerged as an important phosphate bioisostere with reportedly greater cell permeability. It has been used in the synthesis of several therapeutic drug molecules including nucleoside and nucleotide analogues but is yet to be eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d31c8f6f5a22cdb410665b2efb3a1caf
https://pubmed.ncbi.nlm.nih.gov/35423725

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Evaluation of

Autor: R, Sharma, P, Mapelli, G B, Hanna, R, Goldin, D, Power, A, Al-Nahhas, S, Merchant, R, Ramaswami, A, Challapalli, T, Barwick, E O, Aboagye

Publikováno v: EJNMMI Research

Background 3’-Deoxy-3’-[18F]fluorothymidine ([18F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [18F]FLT-PET/CT combined with a temporal-intensity information-based voxel-clus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::228e440c2e693672de0554e23bafa084
https://pubmed.ncbi.nlm.nih.gov/27854031

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Parametric imaging of ¹⁸F-fluoro-3-deoxy-3-L-fluorothymidine PET data to investigate tumour heterogeneity

Autor: M, Veronese, G, Rizzo, E O, Aboagye, A, Bertoldo

Publikováno v: European journal of nuclear medicine and molecular imaging. 41(9)

[(18)F]Fluoro-3'-deoxy-3'-L-fluorothymidine ([(18)F]FLT) is a tissue proliferation marker which has been widely validated as a tumour-specific imaging tracer for PET. [(18)F]FLT uptake in breast cancer is generally quantified at the region level or t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::419171da8dfec4db62029a3950042ac0
https://pubmed.ncbi.nlm.nih.gov/24705620

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Extraction of 5-fluorouracil by tumor and liver: a noninvasive positron emission tomography study of patients with gastrointestinal cancer

Autor: E O, Aboagye, A, Saleem, V J, Cunningham, S, Osman, P M, Price

Publikováno v: Cancer research. 61(13)

Tumor and normal tissue pharmacokinetics of 5-Fluorouracil (5-FU) in patients can be determined with positron emission tomography scanning. However, the data obtained are of limited value because of the inability to distinguish catabolites (inactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d2cf33b80bc940a1e6577a68cde0704
https://pubmed.ncbi.nlm.nih.gov/11431319

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Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues

Autor: S, Osman, G, Rowlinson-Busza, S K, Luthra, E O, Aboagye, G D, Brown, F, Brady, R, Myers, S A, Gamage, W A, Denny, B C, Baguley, P M, Price

Publikováno v: Cancer research. 61(7)

The tricyclic carboxamide N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) is a DNA-intercalating agent capable of inhibiting both topoisomerases I and II and is currently in Phase II clinical trial. Many related analogues have been developed,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::745dd1b56b688c4c6823ced4390c50f4
https://pubmed.ncbi.nlm.nih.gov/11306471

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Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action

Autor: A, Saleem, J, Yap, S, Osman, F, Brady, B, Suttle, S V, Lucas, T, Jones, P M, Price, E O, Aboagye

Publikováno v: Lancet (London, England). 355(9221)

Summary Background Fluorouracil is widely used for chemotherapy of gastrointestinal cancer, but response rates are poor. Eniluracil is being developed as an inactivator of dihydropyrimidine dehydrogenase, the enzyme that brings about first-pass degra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b6c0a2e57d0f182e5017f0a2029fbe
https://pubmed.ncbi.nlm.nih.gov/10902627

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Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitro

Autor: Z M, Bhujwalla, E O, Aboagye, R J, Gillies, V P, Chacko, C E, Mendola, J M, Backer

Publikováno v: Magnetic resonance in medicine. 41(5)

Nm23 genes are involved in the control of the metastatic potential of breast carcinoma cells. To understand the impact of nm23 genes on tumor physiology and metabolism, a 31P nuclear magnetic resonance (NMR) spectroscopic study was performed on tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c6a4d5e76d585b55e31d72f166890df
https://pubmed.ncbi.nlm.nih.gov/10332871

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Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells

Autor: E O, Aboagye, Z M, Bhujwalla

Publikováno v: Cancer research. 59(1)

Transduction of mitogenic signals in cells can be mediated by molecules derived from the synthesis and breakdown of the major membrane phospholipid, phosphotidylcholine. Studies were performed on human mammary epithelial cells in culture to understan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2824c83413982f824528a2139003cd9
https://pubmed.ncbi.nlm.nih.gov/9892190

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