Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation

Autor: Patric J. Ho, Junghun Kweon, Laura A. Blumensaadt, Amy E. Neely, Elizabeth Kalika, Daniel B. Leon, Sanghyon Oh, Cooper W.P. Stringer, Sarah M. Lloyd, Ziyou Ren, Xiaomin Bao

Publikováno v: Cell Genomics, Vol 4, Iss 1, Pp 100471- (2024)

Summary: PBRM1 is frequently mutated in cancers of epithelial origin. How PBRM1 regulates normal epithelial homeostasis, prior to cancer initiation, remains unclear. Here, we show that PBRM1’s gene regulatory roles differ drastically between cell s

Externí odkaz: https://doaj.org/article/12d512de84b3471089ce2f5a0a891fa4

Serologic, Virologic and Pathologic Features of Cats with Naturally Occurring Feline Infectious Peritonitis Enrolled in Antiviral Clinical Trials

Autor: Brian G. Murphy, Diego Castillo, N E Neely, Amir Kol, Terza Brostoff, Chris K. Grant, Krystle L. Reagan

Publikováno v: Viruses, Vol 16, Iss 3, p 462 (2024)

Feline infectious peritonitis (FIP) is a multisystemic, generally lethal immuno-inflammatory disease of domestic cats caused by an infection with a genetic variant of feline coronavirus, referred to as the FIP virus (FIPV). We leveraged data from fou

Externí odkaz: https://doaj.org/article/bb02d15788dd49f1a7821efe0ada804d

Refractive Growth of the Crystalline Lens in the Infant Aphakia Treatment Study

Autor: Thaddeus S. McClatchey, MD, Scott R. Lambert, MD, David G. Morrison, MD, Stacey J. Kruger, MD, Lorri B. Wilson, MD, Scott K. McClatchey, MD, Scott R. Lambert, MD (Study Chair), Lindreth DuBois, MEd, MMSc, CO, COMT (National Coordinator), Azhar Nizam, MS (Director), Qi Long, PhD (former Director), Michael J. Lynn, MS (former Director), Betsy Bridgman, BS, Marianne Celano, PhD, Julia Cleveland, MS, George Cotsonis, MS, Carey Drews-Botsch, PhD, Nana Freret, MSN, Lu Lu, MS, Seegar Swanson, Thandeka Tutu-Gxashe, MPH, E. Eugenie Hartmann, PhD (Director), Anna K. Carrigan, MPH, Clara Edwards, Claudio Busettini, PhD, Samuel Hayley, Eleanor Lewis, Alicia Kindred Joost Felius, PhD, Edward G. Buckley, MD, David A. Plager, MD, M. Edward Wilson, MD, Lindreth DuBois, MEd, MMSc, Carolyn Drews-Botsch, PhD, E. Eugenie Hartmann, PhD, Donald F. Everett, MA, Michael J. Lynn, MS, Qi Long, PhD, Azhar Nizam, MS, Joost Felius, PhD, Margaret Bozic, CCRC, COA, Ann Holleschau, BA, Buddy Russell, COMT, Michael Ward, Carol Bradham, COA, Deborah K. Vanderveen, MD, Theresa A. Mansfield, RN, Kathryn Bisceglia Miller, OD, Tamar Winter, RN, Stephen P. Christiansen, MD, Erick D. Bothun, MD, Jason Jedlicka, OD, Patricia Winters, OD, Jacob Lang, OD, Jill S. Anderson, MD, Elias I. Traboulsi, MD, Susan Crowe, BS, COT, Heather Hasley Cimino, OD, Faruk Orge, MD, Megin Kwiatkowski, Beth Colon, Angela Meador, COA, MHA, Kimberly G. Yen, MD, Maria Castanes, MPH, Alma Sanchez, COA, Shirley York, OD, Stacy Malone, COA, Margaret Olfson, Gihan Romany, MBChB, COMT, CCRC, David T. Wheeler, MD, Ann U. Stout, MD, Paula Rauch, OT, CRC, Kimberly Beaudet, CO, COMT, Pam Berg, CO, COMT, Lorri Wilson, MD, Amy K. Hutchinson, MD, Lindreth Dubois, MEd, MMSc, CO, COMT, Rachel Robb, MMSc, CO, COMT, Marla J. Shainberg, CO, Sharon F. Freedman, MD, Lois Duncan, BS, CO, COMT, B.W. Phillips, FCLSA, John T. Petrowski, OD, Sarah Jones, MS, David Morrison, MD, Sandy Owings, COA, CCRP, Ron Biernacki, CO, COMT, Christine Franklin, COT, Scott Ruark, Daniel E. Neely, MD, Michele Whitaker, COMT, CCRP, Donna Bates, COA, Dana Donaldson, OD, Stacey Kruger, MD, Charlotte Tibi, CO, Susan Vega, David R. Weakley, MD, David R. Stager, Jr., M.D., Clare Dias, CO, Debra L. Sager, Todd Brantley, OD, Bonnie Miller, PhD, Eva Lutz, CO, Lisa Davis, Robert Hardy, PHD (Chair), Eileen Birch, PhD, Ken Cheng, MD, Richard Hertle, MD, Craig Kollman, PhD, Marshalyn Yeargin-Allsopp, MD (resigned), Cyd McDowell, Allen Beck, MD

Publikováno v: Ophthalmology Science, Vol 2, Iss 4, Pp 100208- (2022)

Objective: To compare the rate of refractive growth (RRG3) of the crystalline lens (“lens”) versus the eye excluding the lens (“globe”) for the fellow, noncataractous eyes of participants in the Infant Aphakia Treatment Study. Design: Retrosp

Externí odkaz: https://doaj.org/article/8902367540a64249bec183ced1682f5d

Intense versus standard regimens of intermittent occlusion therapy for unilateral moderate amblyopia in children: study protocol for a randomized controlled trial

Autor: Jingyun Wang, Ayesha Malik, Jing Jin, Yi Pang, Kelly Yin, Megan Allen, Adriana Grigorian, Brandy Scombordi, Joann Bailey, Saeed Aljohani, Katharine Funari, Ruth Shoge, Siva Meiyeppen, Jenny Myung, Ajay Soni, Daniel E. Neely

Publikováno v: Trials, Vol 21, Iss 1, Pp 1-8 (2020)

Abstract Background We reported that in our previous study that wearing intermittent occlusion therapy glasses (IO-therapy) for 4 hours (h) was non-inferior to patching for 2 h in 3 to 8-year-old children with amblyopia. We hypothesize that an intens

Externí odkaz: https://doaj.org/article/b04dce5d75ec416faad841bceab1d591

The Civil War and the Limits of Destruction

Autor: Mark E. Neely Jr

The Civil War is often portrayed as the most brutal war in America's history, a premonition of twentieth-century slaughter and carnage. In challenging this view, Mark E. Neely, Jr., considers the war's destructiveness in a comparative context, reveal