Zobrazeno 1 - 10
of 95
pro vyhledávání: '"E N Yakusheva"'
Publikováno v:
RUDN Journal of Medicine, Vol 21, Iss 4, Pp 432-439 (2017)
The article describes a method of quantitative analysis of anxiolytic drug with neuropro-tective activity - fabomotizole (afobazole) in rabbit blood plasma by HPLC with UV detection at 302 nm. The analysis was performed in isocratic mode using Stayer
Externí odkaz:
https://doaj.org/article/13bfc396c73e4171a233e98eda2cc0da
Publikováno v:
RUDN Journal of Medicine, Vol 0, Iss 4, Pp 118-126 (2016)
On 16 Chinchilla rabbits males of breed with type 2 alloxan diabetes P-glycoprotein functional activity and expression was studied. The diabetes mellitus was modelled by intravenous administration of alloxan monohydrate in the citrate buffer. P-glyco
Externí odkaz:
https://doaj.org/article/be6fae72dfd749b0b210f4a73f51c8cc
Publikováno v:
Антибиотики и Химиотерапия, Vol 68, Iss 5-6, Pp 39-48 (2023)
Antibiotic resistance is a global health problem. Its solution requires concerted efforts on the scale of global cooperation. Programs to prevent the development of antibiotic resistance, as well as to stimulate the development of new drugs with anti
Externí odkaz:
https://doaj.org/article/91ff3e08ea5d4c829a1a7ff969824847
Autor:
M. A. Kopanitsa, Yu. S. Tranova, I. V. Chernykh, A. V. Shchulkin, P. Yu. Mylnikov, O. V. Kalinkina, E. N. Yakusheva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 60-68 (2023)
One way to analyze the activity of the ABCB1 protein is to assess the accumulation of its substrate fexofenadine (F.) inside the test cells. The goal is to develop and validate a method for the quantitative analysis of F. in Caco-2 cell lysate using
Externí odkaz:
https://doaj.org/article/ea7a6b00a0ef43a6b8b11b46ff903fee
Autor:
Yu. S. Tranova, A. A. Slepnev, I. V. Chernykh, A. V. Shchulkin, P. Yu. Mylnikov, N. M. Popova, M. I. Povetko, E. N. Yakusheva
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 12, Iss 2, Pp 87-94 (2023)
Introduction. Breast cancer resistance protein (BCRP) is an efflux membrane transporter that controls the pharmacokinetics of a large number of drugs. Its activity may change when taking some endo- and exogenous substances, thus making it a link in d
Externí odkaz:
https://doaj.org/article/a0fc4f5e332d4ee2a902ab9c13753670
Autor:
Yu. S. Tranova, A. V. Shchulkin, I. V. Chernykh, P. Yu. Mylnikov, A. A. Slepnev, E. N. Yakusheva
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 13, Iss 1, Pp 104-111 (2023)
Mitoxantrone is a marker substrate of breast cancer resistance protein (BCRP). BCRP is involved in a number of pharmacokinetic drug-drug interactions. The transporter’s possible saturability makes it advisable to use low concentrations of mitoxantr
Externí odkaz:
https://doaj.org/article/8960063842404d178ee5227c8c5e7a70
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 10, Iss 1, Pp 104-112 (2022)
The aim of the article is to evaluate the ABCB1 protein inhibition in the blood-brain barrier to increase the effectiveness of neuroprotective therapy for focal and global cerebral ischemia.Materials and methods. The work was performed on 103 male Wi
Externí odkaz:
https://doaj.org/article/f5c111684faf4b17bdd01a63c427341e
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 25-30 (2022)
Relevance. Ethylmethylhydroxypyridine succinate (EMHPS) is a reference domestic drug with pronounced antioxidant and antihypoxic activity. P-Glycoprotein (Pgp) is an ATP-dependent transport protein localized in tissue barriers and protecting cells an
Externí odkaz:
https://doaj.org/article/dd8a44852c5946dc9f16cfad7d26df6d
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 45-51 (2021)
Relevance. BCRP is an efflux transporter protein that plays an important role in the pharmacokinetics of a wide range of drugs. The BCRP activity in vitro experiments is assessed by the transport of transporter protein substrates (methotrexate, etc.)
Externí odkaz:
https://doaj.org/article/10e4547fedfc4d1ca3d2345279e39300
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 8, Iss 1, Pp 40-47 (2020)
The investigation of pharmacokinetics of marker substrates of carrier protein P-glycoprotein (Pgp, ABCB1-protein) including fexofenadine, is one of the methods of its functional activity evaluation.The aim of the study was to work out the HPLC method
Externí odkaz:
https://doaj.org/article/ac9edf860187416aa5b8521522c0fade