Zobrazeno 1 - 10
of 20
pro vyhledávání: '"E N Bush"'
Autor:
Daryl R. Sauer, Jonathan Greer, Charles J. Nichols, Craig D. Wegner, Jason A. Segreti, Kurt M. Mohning, Fortuna Haviv, John T. Randolph, E N Bush, Philip L. Waid, Gilbert Diaz, Leslie M. Besecke, Gary Bammert
Publikováno v:
Journal of Medicinal Chemistry. 47:1085-1097
The design and synthesis of a series of 11,12-cyclic carbamate derivatives of 6-O-methylerythromycin A that are novel, nonpeptide LHRH antagonists, is described. The macrolide antagonist 1, discovered during a screen of our chemical repository, was c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fabef2f09ac213c5e8373f774e466e4
https://doi.org/10.1021/jm030418i
https://doi.org/10.1021/jm030418i
Autor:
Kurt M. Mohning, E N Bush, Van A. Cybulski, Craig D. Wegner, Gilbert Diaz, Randolph John, Mira Rao, Jason A. Segreti, Jonathan Greer, Fortuna Haviv, Philip L. Waid, Leslie M. Besecke
Publikováno v:
Drug Development Research. 52:485-491
Gonadotropin-releasing hormone (GnRH) stimulates the synthesis and secretion of the gonadotropins that maintain the reproductive axis in mammals. Efforts have focused on the characterization of novel, nonpeptidic orally active antagonists of the GnRH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34863a63a9805da58bf9feed4e71ffc9
https://doi.org/10.1002/ddr.1150
https://doi.org/10.1002/ddr.1150
Autor:
P. B. Jacobson, K. M. Krueger, R. S. Bitner, Marlon D. Cowart, M. E. Brune, T. A. Esbenshade, T. A. Fey, R. W. Dickinson, A. A. Hancock, S. Otte, V. E. Knourek-Segel, E. N. Bush, A. L. Nikkel, B. A. Droz, R. Shapiro
Publikováno v:
Inflammation Research. 55:S42-S44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f1fa9bae50248e68de6b79bc939367
https://doi.org/10.1007/s00011-005-0034-0
https://doi.org/10.1007/s00011-005-0034-0
Publikováno v:
Journal of Drug Targeting. 1:251-258
Leuprolide acetate, [D-Leu6-desGly10]LH-RH ethylamide, a highly potent superagonist of luteinizing hormone-releasing hormone (LH-RH), was administered by intraduodenal (ID) injection to male castrate rats in a saline solution. Absorption was low, app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947615d31cd80b7456105229a4f2ead4
https://doi.org/10.3109/10611869308996083
https://doi.org/10.3109/10611869308996083
Autor:
Ramin Faghih, T. R. Miller, P. B. Jacobson, J. K. Pratt, Marlon D. Cowart, R. W. Dickinson, G. Krishna, M. E. Brune, C. A. McDowell, K. M. Krueger, B. A. Droz, M. S. Diehl, R. Shapiro, E. N. Bush, T. A. Fey, T. A. Esbenshade, A. A. Hancock, V. E. Knourek-Segel
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 54
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a8d738b75c7dadd04738bc3285dff6
https://pubmed.ncbi.nlm.nih.gov/15928821
https://pubmed.ncbi.nlm.nih.gov/15928821
Publikováno v:
Pharmaceutical biotechnology. 11
After almost two decades, the research on LHRH antagonists has produced a number of decapeptides that are currently in clinical studies. The structures of these antagonists, unlike the agonists, differ substantially from that of LHRH. Five of the ten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad862198d74b15511ef4e2f4377ef264
https://pubmed.ncbi.nlm.nih.gov/9760679
https://pubmed.ncbi.nlm.nih.gov/9760679
Publikováno v:
Inflammation Research. 53:S47-S48
The increasing worldwide prevalence of obesity creates a need for novel antiobesity treatments having outcomes superior to current drugs [1]. Modulation of CNS histaminergic activity represents a new mechanism because blocking postsynaptic H1 recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9884b99eb323115e49e4c79185cbe2
https://doi.org/10.1007/s00011-003-0322-5
https://doi.org/10.1007/s00011-003-0322-5
Autor:
Timothy D. Fitzpatrick, Charles J. Nichols, J. Knittle, E. N. Bush, E. S. Johnson, J. Greer, Fortuna Haviv, A. T. Nguyen, N. S. Rhutasel, George A. Diaz, Gary Bammert
Publikováno v:
Peptides ISBN: 9789401042956
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4873882e14c1c6259e5ea2a2451d4dcc
https://doi.org/10.1007/978-94-011-0683-2_130
https://doi.org/10.1007/978-94-011-0683-2_130
Autor:
N. S. Rhutasel, J. Greer, V. Cybulski, Fortuna Haviv, Gary Bammert, J. Leal, E. N. Bush, Mort Nicholas A, A. T. Nguyen, J. Knittle, George A. Diaz, Rolf E. Swenson
Publikováno v:
Peptides ISBN: 9789401042956
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf5d5a09d45cac6e5f7b3af2509fcae8
https://doi.org/10.1007/978-94-011-0683-2_150
https://doi.org/10.1007/978-94-011-0683-2_150
Autor:
Rolf E. Swenson, A. T. Nguyen, George A. Diaz, Charles J. Nichols, Timothy D. Fitzpatrick, Fortuna Haviv, E N Bush, Mort Nicholas A, Gary Bammert, N. S. Rhutasel
Publikováno v:
Journal of medicinal chemistry. 36(3)
Each peptide bond in leuprolide (1), deslorelin (13), and nafarelin (24) was separately substituted with N-methyl. The synthesized compounds were tested for in vitro receptor binding, LH release, and stability against chymotrypsin and intestinal degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea76c5aa0f04c3993bf67eb9877f6ff
https://pubmed.ncbi.nlm.nih.gov/8381183
https://pubmed.ncbi.nlm.nih.gov/8381183