Zobrazeno 1 - 10
of 61
pro vyhledávání: '"E N, Pugh"'
Autor:
Tonia S, Rex, John A, Peet, Enrico M, Surace, Peter D, Calvert, Sergei S, Nikonov, Arkady L, Lyubarsky, Elisabeth, Bendo, Thomas, Hughes, E N, Pugh, Jean, Bennett
Publikováno v:
Molecular vision. 11
The concentration of enhanced green fluorescent protein (EGFP) in individual photoreceptor cells of live mouse retina was quantified and correlated with physiological measurements of cell function.EGFP protein levels in the retinas of mice injected s
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(24)
ON bipolar neurons in retina detect the glutamate released by rods and cones via metabotropic glutamate receptor 6 (mGluR6), whose cascade is unknown. The trimeric G-protein G(o) might mediate this cascade because it colocalizes with mGluR6. To test
Autor:
I B, Leskov, V A, Klenchin, J W, Handy, G G, Whitlock, V I, Govardovskii, M D, Bownds, T D, Lamb, E N, Pugh, V Y, Arshavsky
Publikováno v:
Neuron. 27(3)
We have resolved a central and long-standing paradox in understanding the amplification of rod phototransduction by making direct measurements of the gains of the underlying enzymatic amplifiers. We find that under optimized conditions a single photo
Autor:
E N, Pugh
Publikováno v:
Neuron. 23(2)
Publikováno v:
Investigative ophthalmologyvisual science. 39(11)
To measure the dependence of the size of the pupils of mice on steady retinal illumination.Anesthetized C57BL/6 mice aged 7 to 8 weeks were placed in a ganzfeld chamber in darkness, and in monochromatic (510 nm) and white light whose intensity was va
Publikováno v:
Investigative ophthalmologyvisual science. 38(9)
To investigate the transitory plateaux observed during dark adaptation after partial bleaches in Sorsby's fundus dystrophy (SFD) and in systemic vitamin A deficiency (VAD).Psychophysical dark adaptation functions were measured after bleaching exposur
Publikováno v:
Investigative ophthalmologyvisual science. 37(1)
To assess the effect of light-rearing history on the photon-capturing ability, amplitude, and kinetics of the fast-PIII response of the retina.Albino rats were raised on 12-hour light-12-hour dark cycles, with illumination at 3 lux or 200 lux, and ki
Publikováno v:
Investigative ophthalmologyvisual science. 35(1)
To test rigorously the hypothesis that the a-wave of the electroretinogram (ERG) is proportional to the rod photocurrent by examining the applicability to a-waves of a recent model of the activation steps in the G-protein cascade of phototransduction