Výsledky vyhledávání

Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice

Autor: Michelle Darrieux, E. N. Miyaji, Jorge Ferreira, Daniela M. Ferreira, Paulo Lee Ho, Luciana C. C. Leite, Maria Leonor S. Oliveira, D. A. Silva

Publikováno v: Clinical and Vaccine Immunology. 16:636-645

Pneumococcal surface protein A (PspA) and PspC are virulence factors that are involved in the adhesion of Streptococcus pneumoniae to epithelial cells and/or evasion from the immune system. Here, the immune responses induced by mucosal vaccines compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178f034d6c92192829ad2b86f1d4ac83
https://doi.org/10.1128/cvi.00395-08

Zobrazit plný text záznamu

Fusion Proteins Containing Family 1 and Family 2 PspA Fragments Elicit Protection against Streptococcus pneumoniae That Correlates with Antibody-Mediated Enhancement of Complement Deposition

Autor: Bing Ren, Susan K. Hollingshead, Michelle Darrieux, Luciana C. C. Leite, L. M. Lopes, David E. Briles, E. N. Miyaji, Alexandre P. Y. Lopes, Daniela M. Ferreira

Publikováno v: Infection and Immunity. 75:5930-5938

PspA is an important pneumococcal vaccine candidate that is capable of inducing protection in different animal models. Because of its structural diversity, a PspA-based vaccine should contain at least one fragment from each of the two major families

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6864e06b1d2b78430a4e6ced64aafb7
https://doi.org/10.1128/iai.00940-07

Zobrazit plný text záznamu

Human BCL-2 Expression Delays Ultraviolet-Induced Apoptosis in Marsupial Cells

Autor: E. N. Miyaji, Carlos Frederico Martins Menck

Publikováno v: Photochemistry and Photobiology. 68:719-724

We have introduced the human bcl-2 gene under the control of the human metallothionein MTIIA promoter into the rat kangaroo PtK2 cell line. Two independent clones were obtained in which the levels of Bcl-2 protein expression can be controlled by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44d543b017c09fcb9a90dea05dacd517
https://doi.org/10.1111/j.1751-1097.1998.tb02535.x

Zobrazit plný text záznamu

Photoreversion of ultraviolet induced apoptosis in Rat Kangaroo cells

Autor: Carlos Frederico Martins Menck, E. N. Miyaji

Publikováno v: Apoptosis. 1:153-160

Rat kangaroo(Potorous tridactylus) cells efficiently repair 254 nm ultraviolet light (UV) induced cyclobutane pyrlmidine dimers (CPDs) through photoreactivation, leading to an enhancement of survival when cells are exposed to photoreactivation light

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28d49deb8d8bf0b9f2be462916fbe55d
https://doi.org/10.1007/bf01321022

Zobrazit plný text záznamu

Trends in adjuvant development for vaccines: DAMPs and PAMPs as potential new adjuvants

Autor: E N, Miyaji, E, Carvalho, M L S, Oliveira, I, Raw, P L, Ho

Publikováno v: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 44(6)

Aluminum salts have been widely used in vaccine formulations and, after their introduction more than 80 years ago, only few vaccine formulations using new adjuvants were developed in the last two decades. Recent advances in the understanding of how i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46ad46c2c6939295420d5591ed89b4db
https://pubmed.ncbi.nlm.nih.gov/21584443

Zobrazit plný text záznamu

Nasal immunization of mice with Lactobacillus casei expressing the Pneumococcal Surface Protein A: induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge

Autor: Débora A. Silva, Maria Leonor S. Oliveira, Michelle Darrieux, Ivana B. Campos, Karina Araújo Aires, Luciana C. C. Leite, Ana Paula Mattos Arêas, E. N. Miyaji, Daniela M. Ferreira, Paulo Lee Ho

Publikováno v: Microbes and infection. 10(5)

Strategies for the development of new vaccines against Streptococcus pneumoniae infections try to overcome problems such as serotype coverage and high costs, present in currently available vaccines. Formulations based on protein candidates that can i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7972f556d5edd567c4fbff66dbea786e
https://pubmed.ncbi.nlm.nih.gov/18403234

Zobrazit plný text záznamu

Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice

Autor: F C, Pimenta, E N, Miyaji, A P M, Arêas, M L S, Oliveira, A L S S, de Andrade, P L, Ho, S K, Hollingshead, L C C, Leite

Publikováno v: Infection and immunity. 74(8)

One of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniae is PsaA (pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible alterations in the normal microbiota, especia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a37adbf0170c5791fc138a5802d8426
https://pubmed.ncbi.nlm.nih.gov/16861686

Zobrazit plný text záznamu

Expression of Streptococcus pneumoniae antigens, PsaA (pneumococcal surface antigen A) and PspA (pneumococcal surface protein A) by Lactobacillus casei

Autor: Luciana C. C. Leite, Paulo Lee Ho, Gaspar Pérez-Martínez, E. N. Miyaji, Vicente Monedero, Maria Leonor S. Oliveira

Publikováno v: FEMS microbiology letters. 227(1)

A number of recent research works in lactic acid bacteria aim towards the design of new strains that could be used as live vectors for the delivery of antigens for oral vaccination, or other therapeutic molecules. In this work, an inducible expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfc1379755b438a3a353f15c4f0e28e
https://pubmed.ncbi.nlm.nih.gov/14568144

Zobrazit plný text záznamu

Protective efficacy of PspA (pneumococcal surface protein A)-based DNA vaccines: contribution of both humoral and cellular immune responses

Autor: E. N. Miyaji, Waldely O. Dias, Martha M. Tanizaki, Luciana C. C. Leite

Publikováno v: FEMS immunology and medical microbiology. 37(1)

Streptococcus pneumoniae is a major public health problem and new strategies for the development of cost-effective alternative vaccines are important. The use of protein antigens such as PspA (pneumococcal surface protein A) is a promising approach t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f18afb9a76bb86bb03750c75e53039c
https://pubmed.ncbi.nlm.nih.gov/12770760

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání