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Autor:
Christian Beyer, Jean-Louis Gendrault, Anne-Marie Steffan, E. Muchmore, Anne-Marie Aubertin, André Kirn, Yury Persidsky, Catherine A. Royer
Publikováno v:
Research in Virology. 146:185-200
Four patterns of structural alterations were found in lymph nodes (LNs) from rhesus monkeys 17 to 34 months after infection with simian immunodeficiency virus (SIV-mac251). SIV p27gag antigen and viral particles were localized either between the proc
Autor:
J, Estaquier, T, Idziorek, F, de Bels, F, Barré-Sinoussi, B, Hurtrel, A M, Aubertin, A, Venet, M, Mehtali, E, Muchmore, P, Michel, Y, Mouton, M, Girard, J C, Ameisen
Publikováno v:
Proceedings of the National Academy of Sciences. 91:9431-9435
We have proposed that inappropriate induction of programmed cell death (PCD) or apoptosis, a physiological cell-suicide process, may play a role in the pathogenesis of AIDS. This model has been supported by several reports of abnormal levels of PCD i
Autor:
E, Muchmore
Publikováno v:
Methods in molecular medicine. 19
Chimpanzees (Pan troglodytes) became established as invaluable models for the study of human viral hepatitis after it was discovered, in 1967, that the chronic hepatitis B antigen carrier state existed in a naturally infected member of this species (
Publikováno v:
The Journal of Immunology. 151:4189-4199
Hepatitis C virus (HCV)-specific CTL responses were evaluated in two chimpanzees (Pan troglodytes) during the acute and chronic phases of HCV infection. CD8+ T lymphocytes were isolated from liver tissue homogenates using anti-CD8 antibody-coated mag
Autor:
Xiang-Bin Kong, Donald Armstrong, Qing-Yu Zhu, M. Ostrander, K. A. Watanabe, Bruce Polsky, T.-C. Chou, S. A. Lang, E. Muchmore, Pedro M. Vidal
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:808-818
3'-Fluoro-3'-deoxythymidine (FLT), a candidate anti-AIDS compound in clinical trials, showed anti-human immunodeficiency virus type 1 (HIV-1) potency (50% effective concentration, 0.0052 microM) slightly better than or equal to that of 3'-azido-3'-de
Publikováno v:
Hepatology (Baltimore, Md.). 28(2)
The controversial question of the extent of hepatocyte infection in chronic hepatitis C was re-examined in both chimpanzees and humans using a newly modified in situ hybridization (ISH) method for detecting hepatitis C virus (HCV) RNA. The specificit
Publikováno v:
Molecular marine biology and biotechnology. 7(1)
A tandemly repeated satellite DNA of 290-291 base pairs (bp) was identified by SalI digestion of genomic DNA of five species of Eastern Pacific (California) abalone (genus, Haliotis). Following cloning and sequencing of one repeat unit from one speci
Autor:
Y, Persidsky, A M, Steffan, J L, Gendrault, B, Hurtrel, S, Berger, C, Royer, H J, Stutte, E, Muchmore, A M, Aubertin, A, Kirn
Publikováno v:
Hepatology (Baltimore, Md.). 21(5)
The pathogenesis of liver injury, which remains unclear in the course of human immunodeficiency virus infection, can be investigated in simian immunodeficiency virus-infected macaques, which develop an immunodeficiency disease resembling human acquir
Publikováno v:
Princess Takamatsu symposia. 25
Mechanisms by which HCV evades the cellular immune response in persistently infected humans and chimpanzees are poorly defined, but could involve mutations in epitopes recognized by class I MHC restricted CTLs. To investigate this possibility, we ide