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Biochemical and Structural Investigation of GnnA in the Lipopolysaccharide Biosynthesis Pathway of Acidithiobacillus ferrooxidans

Autor: Jenny Rose E Montalban, Kittikhun Wangkanont, Thassanai Sitthiyotha, Surasak Chunsrivirot, Juthatip Manissorn, Peerapat Thongnuek

Publikováno v: ACS Chemical Biology. 15:3235-3243

Lipopolysaccharide (LPS) is a crucial component in the outer membrane of Gram-negative bacteria that contributes to both pathogenicity as well as immunity against pathogenic bacteria. Typical LPS contains GlcN disaccharide as the core of lipid A. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae959a667c7bcb973a2c8a36128009be
https://doi.org/10.1021/acschembio.0c00791

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Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study

Autor: Marije Van Schalkwyk, Lerato Mohapi, R Luk, Peter Mugyenyi, RT Schooley, SN Fontain, Beatriz Grinsztejn, Cecilia Kanyama, T Sise, A Collier, R Salata, J Valencia, P Sugandhavesa, BR Santos, Patcharaphan Sugandhavesa, Carole L. Wallis, Breno Santos, R Walensky, R Gross, H Mugerwa, SW Cardoso, J Rooney, Justin Ritz, L Hovind, Sharlaa Faesen, Robert E. Gross, CV Fletcher, L Wieclaw, Evelyn Hogg, A Shahkolahi, M van Schalkwyk, W Samaneka, Y van Delft, John W. Mellors, S Faesen, C Wallis, Aggrey Bukuru, Robert T. Schooley, Anchalee Avihingsanon, N Kumarasamy, J van Wyk, D Kadam, C Godfrey, R Leavitt, Ann C. Collier, R Secours, C Kanyama, Mumbi Makanga, L Nakibuuka, H Nassolo, Wadzanai Samaneka, M Gandhi, Esmelda Montalban, R Mngqibisa, Javier Valencia, P Anthony, Vidya Mave, Rosie Mngqibisa, V Kulkarni, E Hogg, Nagalingeswaran Kumarasamy, V Mave, Robert A. Salata, Catherine Godfrey, A Benns, M Hughes, A Avihingsanon, B Grinsztejn, B Mansfield, PN Mugyenyi, M Nsubuga, M Makanga, Michael Hughes, Sandra W. Cardoso, J Ritz, Linda Wieclaw, Rode Secours, Sandy Nerette Fontain, Beatrice Wangari Ndege, BW Ndege, E Montalban

Publikováno v: Lancet HIV

Summary Background Antiretroviral therapy (ART) management is challenging for individuals in resource-limited settings presenting for third-line treatment because of complex resistance patterns, partly due to reduced access to viral load monitoring.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f078ada1a0d0932b29304d8b17fbc82
https://pubmed.ncbi.nlm.nih.gov/31371262