Zobrazeno 1 - 10
of 2 577
pro vyhledávání: '"E McCarthy"'
Autor:
Adam C. Oken, Nicolas E. Lisi, Ipsita Krishnamurthy, Alanna E. McCarthy, Michael H. Godsey, Arthur Glasfeld, Steven E. Mansoor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract P2X receptors are trimeric ATP-gated ion channels that activate diverse signaling cascades. Due to its role in apoptotic pathways, selective activation of P2X7 is a potential experimental tool and therapeutic approach in cancer biology. Howe
Externí odkaz:
https://doaj.org/article/3c89490806f045458206f861b602e1d4
Autor:
Claire E McCarthy-Leo, George S Brush, Roger Pique-Regi, Francesca Luca, Michael A Tainsky, Russell L Finley
Publikováno v:
PLoS Genetics, Vol 20, Iss 8, p e1011375 (2024)
Loss of function mutations in the checkpoint kinase gene CHEK2 are associated with increased risk of breast and other cancers. Most of the 3,188 unique amino acid changes that can result from non-synonymous single nucleotide variants (SNVs) of CHEK2,
Externí odkaz:
https://doaj.org/article/dbc2b294a8f0487bb7f4649e6a718c48
Publikováno v:
Frontiers in Mechanical Engineering, Vol 10 (2024)
Externí odkaz:
https://doaj.org/article/323d6f1ba4fc45ef9e4f40075092a264
Autor:
Wendy S. Slutske, Karen L. Conner, Julie A. Kirsch, Stevens S. Smith, Thomas M. Piasecki, Adrienne L. Johnson, Danielle E. McCarthy, Patricia Nez Henderson, Michael C. Fiore
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract American Indian and Alaska Native (AI/AN) individuals are more likely to die with COVID-19 than other groups, but there is limited empirical evidence to explain the cause of this inequity. The objective of this study was to determine whether
Externí odkaz:
https://doaj.org/article/0481583ef7394d9dace3287afc198c02
Autor:
Pazhanichamy Kalailingam, Khalilatul‐Hanisah Mohd‐Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O'Leary, Kah Leong Lim, I Hsin Su, Yong‐Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy, Siu Kwan Sze
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-16 (2023)
Abstract Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age‐linked damage to amino acid sequence NGR (Asn‐Gly‐Arg) results in “gain‐of‐function” conformatio
Externí odkaz:
https://doaj.org/article/0e78e068254840989c041da6a4477442
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011668 (2024)
Stable microbial colonization of the skin depends on tight control by the host immune system. The lipid-dependent yeast Malassezia typically colonizes skin as a harmless commensal and is subject to host type 17 immunosurveillance, but this fungus has
Externí odkaz:
https://doaj.org/article/7ff6924a5f0245e7815e91c8c5225c63
Autor:
Matthew R. Brier, Zhuocheng Li, Maria Ly, Helmet T. Karim, Leda Liang, Weixin Du, John E. McCarthy, Anne H. Cross, Tammie L. S. Benzinger, Robert T. Naismith, Salim Chahin
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 6, Pp 990-1001 (2023)
Abstract Objective Neurodegenerative conditions often manifest radiologically with the appearance of premature aging. Multiple sclerosis (MS) biomarkers related to lesion burden are well developed, but measures of neurodegeneration are less well‐de
Externí odkaz:
https://doaj.org/article/e2f59ab7413a4ad68ea2230b130a9593
Autor:
Tanja Petnicki-Ocwieja, Julie E McCarthy, Urmila Powale, P Kent Langston, Jennifer D Helble, Linden T Hu
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011886 (2023)
Borrelia burgdorferi (Bb), the causative agent of Lyme disease, establishes a long-term infection and leads to disease manifestations that are the result of host immune responses to the pathogen. Inflammatory manifestations resolve spontaneously desp
Externí odkaz:
https://doaj.org/article/4d2f34deaaed43e292d0514d8b44589a
Autor:
Elizabeth D. Barnett, Alyse B. Wheelock, William B. MacLeod, Anne E. McCarthy, Patricia F. Walker, Christina M. Coyle, Christina A. Greenaway, Francesco Castelli, Rogelio López-Vélez, Federico G. Gobbi, Elena Trigo, Martin P. Grobusch, Philippe Gautret, Davidson H. Hamer, MD, Susan Kuhn, William M. Stauffer
Publikováno v:
Travel Medicine and Infectious Disease, Vol 56, Iss , Pp 102653- (2023)
Background: The continued increase in global migration compels clinicians to be aware of specific health problems faced by refugees, immigrants, and migrants (RIM). This analysis aimed to characterize RIM evaluated at GeoSentinel sites, their migrati
Externí odkaz:
https://doaj.org/article/940a4adeae244cd09c636ea954a85389
Autor:
Jennifer D. Helble, Michael J. Walsh, Julie E. McCarthy, Neal P. Smith, Alice J. Tirard, Benjamin Y. Arnold, Alexandra-Chloe Villani, Linden T. Hu
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108217- (2023)
Summary: Lyme disease is caused by the bacterial pathogen Borrelia burgdorferi, which can be readily modeled in laboratory mice. In order to understand the cellular and transcriptional changes that occur during B. burgdorferi infection, we conducted
Externí odkaz:
https://doaj.org/article/d6183220150540f2ace8e1063c19b325