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Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes.

Autor: Giovanni Di Pasquale, Ilaria Dicembrini, Laura Raimondi, Claudio Pagano, Josephine M Egan, Andrea Cozzi, Lorenzo Cinci, Andrea Loreto, Maria E Manni, Silvia Berretti, Annamaria Morelli, Changyu Zheng, Drew G Michael, Mario Maggi, Roberto Vettor, John A Chiorini, Edoardo Mannucci, Carlo M Rotella

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40074 (2012)

Exendin-4 (Ex-4) is a Glucagon-like peptide 1 (GLP-1) receptor agonist approved for the treatment of Type 2 Diabetes (T2DM), which requires daily subcutaneous administration. In T2DM patients, GLP-1 administration is reported to reduce glycaemia and

Externí odkaz: https://doaj.org/article/b5a58b6ba4de46ae91ab1ee5fd254e6b

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Operations research in solid waste management: a survey of strategic and tactical issues

Autor: E. Manni, Gianpaolo Ghiani, D. Laganí, Roberto Musmanno, Daniele Vigo

Publikováno v: Ghiani, G, Laganà, D, Manni, E, Musmanno, R & Vigo, D 2014, ' Operations research in solid waste management: A survey of strategic and tactical issues ', Computers and Operations Research, vol. 44, no. April, pp. 22-32 . https://doi.org/10.1016/j.cor.2013.10.006
Computers and Operations Research, 44(April), 22-32. Elsevier Limited

Solid waste management (SWM) is an increasingly complex task, absorbing a huge amount of resources and having a major environmental impact. Computerized systems based on operations research techniques can help decision makers to achieve remarkable co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc3ee4262dbbda047fb2db01deaf8eb
https://hdl.handle.net/11587/389629