Zobrazeno 1 - 10
of 29
pro vyhledávání: '"E M Rubin"'
Autor:
J K Bielicki, T M Forte, M R McCall, L J Stoltzfus, G Chiesa, C R Sirtori, G Franceschini, E M Rubin
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 11, Pp 2314-2321 (1997)
Human carriers of apolipoprotein A-I(Milano) (Arg173 –> Cys substitution in apolipoprotein A-I) are characterized by an HDL deficiency in which small, dense HDL accumulate in plasma. Because affected individuals are heterozygous for this mutation,
Externí odkaz:
https://doaj.org/article/d5ace512eee243eaa4b49d2f0477d099
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 11, Pp 2320-2328 (1995)
Murine strains susceptible to atherosclerosis provide valuable models to study factors involved in atherogenesis. In some murine models, limited hypercholesterolemia can be achieved and lesions develop primarily in the aortic origin, in the vicinity
Externí odkaz:
https://doaj.org/article/39da6014750f4cc0a29827772f6fd4f9
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 3, Pp 593-600 (1995)
The direct non-endocytotic uptake of cholesteryl esters (CE) from high density lipoprotein (HDL) plays a major role in HDL CE metabolism in rats and rabbits. In vitro evidence indicates it may also play such a role in humans. However, a study in mice
Externí odkaz:
https://doaj.org/article/d55744984c2b49ada9d1d91730418ba0
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 12, Pp 2263-2267 (1994)
Elevated levels of apolipoprotein[a] (apo[a]) and apolipoprotein A-I (apoA-I) are associated, respectively, with increased and decreased atherosclerosis risk, in both humans and transgenic mice. To investigate the interactions of these two important
Externí odkaz:
https://doaj.org/article/e194990353ce4ec0a81302e5254efe18
Autor:
W R Shehee, T M Townes, J B Whitney rd, A Leder, Jada Lewis, R A Popp, C Paszty, Oliver Smithies, E M Rubin
Publikováno v:
Biochemical Genetics. 36:65-77
The hematology of the laboratory mouse has been well characterized. Normal genetic differences at the alpha- and beta-globin gene loci serve as useful markers for a wide variety of types of experimental studies. There are a number of naturally occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a2c86dc6fe79d84008e3b55b9913f9
https://doi.org/10.1023/a:1018752219810
https://doi.org/10.1023/a:1018752219810
Publikováno v:
The Journal of Immunology. 159:5773-5776
Evidence suggests that the Ras/mitogen-activated protein kinase signaling pathway is required for positive selection of thymocytes. We have asked whether Ras activation is also sufficient to mediate changes in gene expression that are associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdb4fb83a9018768a099c1927e0ee062
https://doi.org/10.4049/jimmunol.159.12.5773
https://doi.org/10.4049/jimmunol.159.12.5773
Publikováno v:
Journal of Clinical Investigation. 96:1440-1448
Human (Hu) lecithin-cholesterol acyltransferase (LCAT) is a key enzyme in the plasma metabolism of cholesterol. To assess the effects of increased plasma levels of LCAT, four lines of transgenic mice were created expressing a Hu LCAT gene driven by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab91cfeba7274a6769174dc612327ffb
https://doi.org/10.1172/jci118180
https://doi.org/10.1172/jci118180
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 3, Pp 593-600 (1995)
The direct non-endocytotic uptake of cholesteryl esters (CE) from high density lipoprotein (HDL) plays a major role in HDL CE metabolism in rats and rabbits. In vitro evidence indicates it may also play such a role in humans. However, a study in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e723f93dc4c660586c64647795eee87
https://doi.org/10.1016/s0022-2275(20)39893-x
https://doi.org/10.1016/s0022-2275(20)39893-x
Autor:
L, Stoltzfus, E M, Rubin
Publikováno v:
Trends in cardiovascular medicine. 3(4)
Owing to the investigative power of classical mouse genetics and the development of transgenic and gene-targeting technologies, the mouse has increasingly been used to study atherogenesis. Investigators have manipulated the plasma levels of several p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7024a2cb5ecd26492954d36c4444f915
https://pubmed.ncbi.nlm.nih.gov/21244939
https://pubmed.ncbi.nlm.nih.gov/21244939
Publikováno v:
Science (New York, N.Y.). 288(5475)
In their Report “Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons” (7 Apr., p. [136][1]), G. G. Loots and colleagues identify conserved noncoding sequences (CNSs) in orthologous regions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b1ff223fd902167953bc80fc864f81
https://pubmed.ncbi.nlm.nih.gov/17769838
https://pubmed.ncbi.nlm.nih.gov/17769838