Zobrazeno 1 - 10
of 165
pro vyhledávání: '"E M, Kelly"'
Autor:
Uwe Grether, Richard H. Foxton, Sabine Gruener, Claudia Korn, Atsushi Kimbara, Anja Osterwald, Elisabeth Zirwes, Sabine Uhles, Janina Thoele, Nadine Colé, Mark Rogers-Evans, Stephan Röver, Matthias Nettekoven, Rainer E. Martin, Jean-Michel Adam, Jürgen Fingerle, Caterina Bissantz, Wolfgang Guba, André Alker, Anna M. Szczesniak, Ross F. Porter, Tom J. Toguri, Franco Revelant, Agnès Poirier, Camille Perret, Lotte Winther, Antonello Caruso, Filomena Fezza, Mauro Maccarrone, Melanie E. M. Kelly, Sascha Fauser, Christoph Ullmer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionPreclinical studies suggest that cannabinoid receptor type 2 (CB2R) activation has a therapeutic effect in animal models on chronic inflammation and vascular permeability, which are key pathological features of diabetic retinopathy (DR).
Externí odkaz:
https://doaj.org/article/91d1c3e1c6e44284b2f5d719fd280ff1
Autor:
Eliza M. Gordon‐Lipkin, Christopher S. Marcum, Shannon Kruk, Elizabeth Thompson, Sophie E. M. Kelly, Heather Kalish, Lorenza Bellusci, Surender Khurana, Kaitlyn Sadtler, Peter J. McGuire
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract Background Viral infection is a major cause of morbidity in children with mitochondrial disease (MtD). As a result, families with children with MtD are highly adherent to risk mitigation behaviours (RMBs) advised by the Centers for Disease C
Externí odkaz:
https://doaj.org/article/f445df924f74444d862fd437e2858e7f
Autor:
Brian P Epling, Joseph M Rocco, Kristin L Boswell, Elizabeth Laidlaw, Frances Galindo, Anela Kellogg, Sanchita Das, Allison Roder, Elodie Ghedin, Allie Kreitman, Robin L Dewar, Sophie E M Kelly, Heather Kalish, Tauseef Rehman, Jeroen Highbarger, Adam Rupert, Gregory Kocher, Michael R Holbrook, Andrea Lisco, Maura Manion, Richard A Koup, Irini Sereti
Publikováno v:
Clinical Infectious Diseases. 76:573-581
Background Nirmatrelvir/ritonavir, the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease inhibitor, reduces the risk of hospitalization and death by coronavirus disease 2019 (COVID-19) but has been associated with symptomati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5048ffdbe16bdbdb0012f954d6ce766
https://doi.org/10.1093/cid/ciac663
https://doi.org/10.1093/cid/ciac663
Autor:
Robert B. Laprairie, Kawthar A. Mohamed, Ayat Zagzoog, Melanie E. M. Kelly, Lesley A. Stevenson, Roger Pertwee, Eileen M. Denovan-Wright, Ganesh A. Thakur
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with
Externí odkaz:
https://doaj.org/article/0af22acc2b2c405fb3735e48f6927486
Autor:
Dinesh Thapa, Elizabeth A. Cairns, Anna-Maria Szczesniak, Pushkar M. Kulkarni, Alex J. Straiker, Ganesh A. Thakur, Melanie E. M. Kelly
Publikováno v:
Molecules, Vol 25, Iss 2, p 417 (2020)
Cannabinoid receptor 1 (CB1) activation has been reported to reduce transient receptor potential cation channel subfamily V member 1 (TRPV1)-induced inflammatory responses and is anti-nociceptive and anti-inflammatory in corneal injury. We examined w
Externí odkaz:
https://doaj.org/article/5491ec7caf8a4f16b8f314dcc731ee7d
Publikováno v:
Neurourology and Urodynamics. 40:1704-1719
Aims Long-term or recreational use of ketamine affects the urinary system and can result in ketamine-induced cystitis (KIC). Rodent models of KIC are important to study KIC pathophysiology and are paramount to the future development of therapies for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57d500c96f656838bb85defe9b1ebe0
https://doi.org/10.1002/nau.24763
https://doi.org/10.1002/nau.24763
Autor:
Richard Frederick Porter, Anna-Maria Szczesniak, James Thomas Toguri, Simon Gebremeskel, Brent Johnston, Christian Lehmann, Jürgen Fingerle, Benno Rothenhäusler, Camille Perret, Mark Rogers-Evans, Atsushi Kimbara, Matthias Nettekoven, Wolfgang Guba, Uwe Grether, Christoph Ullmer, Melanie E. M. Kelly
Publikováno v:
Molecules, Vol 24, Iss 18, p 3338 (2019)
(1) Background: The cannabinoid 2 receptor (CB2R) is a promising anti-inflammatory drug target and development of selective CB2R ligands may be useful for treating sight-threatening ocular inflammation. (2) Methods: This study examined the pharmacolo
Externí odkaz:
https://doaj.org/article/ef31d0daf6414bf7b58b32c719590b99
Autor:
Eileen M. Denovan-Wright, Susan E. Howlett, Melanie E. M. Kelly, Jiequan Zhu, Amina M. Bagher, Alexander P. Young
Publikováno v:
GeroScience. 43:1447-1463
The human brain requires adequate cerebral blood flow to meet the high demand for nutrients and to clear waste products. With age, there is a chronic reduction in cerebral blood flow in small resistance arteries that can eventually limit proper brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7322dd7215d4dd293f2b5213118dbff
https://doi.org/10.1007/s11357-020-00309-7
https://doi.org/10.1007/s11357-020-00309-7
Autor:
Brian P. Epling, Joseph M. Rocco, Kristin L. Boswell, Elizabeth Laidlaw, Frances Galindo, Anela Kellogg, Sanchita Das, Allison Roder, Elodie Ghedin, Allie Kreitman, Robin L. Dewar, Sophie E. M. Kelly, Heather Kalish, Tauseef Rehman, Jeroen Highbarger, Adam Rupert, Gregory Kocher, Michael R. Holbrook, Andrea Lisco, Maura Manion, Richard A. Koup, Irini Sereti
Publikováno v:
medRxiv : the preprint server for health sciences.
Clinical rebound of COVID-19 after nirmatrelvir/ritonavir treatment has been reported. We performed clinical, virologic, and immune measurements in seven patients with symptomatic rebound, six after nirmatrelvir/ritonavir treatment and one without pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274ed9ce8bd7e9aae30862858c6cd222
https://pubmed.ncbi.nlm.nih.gov/36200701
https://pubmed.ncbi.nlm.nih.gov/36200701
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the diso
Externí odkaz:
https://doaj.org/article/2adbc9b901a7423992bd3e1ed80f80d4