Zobrazeno 1 - 7
of 7
pro vyhledávání: '"E M, Jagoda"'
Publikováno v:
Synapse (New York, N.Y.). 31(1)
Based on encouraging in vitro data indicating M2 subtype selectivity, we synthesized, radiolabeled with 18F, and evaluated 3-(3-(2-fluoroethylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetr ahydro-1-methylpyridine [FE-TZTP], and 3-(3-(3-fluoropropylthio)-1
Autor:
D O, Kiesewetter, R E, Carson, E M, Jagoda, C J, Endres, M G, Der, P, Herscovitch, W C, Eckelman
Publikováno v:
Bioorganicmedicinal chemistry. 5(8)
We have developed a multistep radiochemical synthesis of two diastereomers of quinuclidinyl-4-[18F]-fluoromethyl-benzilate ([18F]-FMeQNB), a high-affinity ligand for muscarinic acetylcholine receptors. Previously, we have shown that the nonradioactiv
Autor:
M E, McManaway, E M, Jagoda, W C, Eckelman, S M, Larson, B E, Francis, R E, Gibson, R C, Reba, M E, Lippman
Publikováno v:
Cancer research. 46(5)
17 alpha-[125I]Iodovinyl-11 beta-methoxyestradiol ([125I]MIVE2), a gamma-emitting analogue of estradiol, previously shown to bind to rat uterine estradiol receptor, was studied to determine the binding characteristics and biological activity in human
Autor:
E M, Jagoda, R E, Gibson, H, Goodgold, N, Ferreira, B E, Francis, R C, Reba, W J, Rzeszotarski, W C, Eckelman
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 25(4)
17 alpha-[125I[Iodovinyl 11 beta-methoxyestradiol ([I-125]MIVE2) has been prepared with high specific activity (1500-2000 Ci/mmol) and a high affinity for the estrogen receptor (KA = 6.8 x 10(9) M/Ml). In vivo distribution studies using immature rats
Autor:
M E, McManaway, E M, Jagoda, A, Kasid, W C, Eckelman, B E, Francis, S M, Larson, R E, Gibson, R C, Reba, M E, Lippman
Publikováno v:
Cancer research. 47(11)
[125I]17-alpha-Iodovinyl 11-beta-methoxyestradiol [( 125I]MIVE2) has been evaluated as a potential radiotracer for the diagnostic imaging of estrogen receptor (ER)-positive human breast cancer. In vivo distribution experiments with athymic ovariectom
Autor:
W. J. RZESZOTARSKI, W. C. ECKELMAN, B. E. FRANCIS, D. A. SIMMS, R. E. GIBSON, E. M. JAGODA, M. P. GRISSOM, R. R. ENG, J. J. CONKLIN, R. C. REBA
Publikováno v:
Chemischer Informationsdienst. 15
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 25(2)
The accumulation of (R)-(H-3)-3-quinuclidinyl benzilate (H-3 QNB) and (R,S)-1-azabicyclo(2.2.2)oct-3-yl (R,S)-alpha-hydroxy-(4-[I-125]iodophenyl) benzeneacetate (I-125 4- IQNB ) in heart, caudate/putamen, and cerebellum of rats was determined at inte