Výsledky vyhledávání - "E M, Horwitz"

Correction of a mineralization defect by overexpression of a wild-type cDNA for COL1A1 in marrow stromal cells (MSCs) from a patient with osteogenesis imperfecta: a strategy for rescuing mutations that produce dominant-negative protein defects

Autor: Darwin J. Prockop, D S Stokes, E M Horwitz, Radhika Pochampally, C M DiGirolamo

Publikováno v: Gene Therapy. 12:1119-1125

Gene therapy for dominant-negative disorders presents a more difficult challenge than gene therapy for recessive disorders, since even partial replacement of a protein for a recessive disorder can reverse symptoms. Osteogenesis imperfecta (OI) has fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7184e3decb9c330969f9cdeb3c57a3
https://doi.org/10.1038/sj.gt.3302514

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A human protein containing a 'cold shock' domain binds specifically to H-DNA upstream from the human gamma-globin genes

Autor: K A Maloney, Timothy J. Ley, E M Horwitz

Publikováno v: Journal of Biological Chemistry. 269:14130-14139

We previously determined that a region between positions -228 and -189 upstream from the human gamma-globin genes can form an intramolecular triplex (H-DNA) in supercoiled plasmids. To identify proteins that might interact with this DNA structure, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::472635defda22d5981aa5bf6be005ded
https://doi.org/10.1016/s0021-9258(17)36764-9

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Altitude, life expectancy and mortality from ischaemic heart disease, stroke, COPD and cancers: national population-based analysis of US counties

Autor: Timothy Clark, Christopher J L Murray, Deborah S.K. Thomas, Mara E M Horwitz, Majid Ezzati, Robert C. Roach, Benjamin Honigman, Ari B. Friedman

Publikováno v: Journal of epidemiology and community health. 66(7)

Background There is a substantial variation in life expectancy across US counties, primarily owing to differentials in chronic diseases. The authors9 aim was to examine the association of life expectancy and mortality from selected diseases with alti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3556bc7741f7da4f6535c35095e3397
https://pubmed.ncbi.nlm.nih.gov/21406589

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The treatment of non-metastatic prostate cancer with external beam radiation therapy

Autor: E M, Horwitz, S J, Feigenberg, R G, Uzzo

Publikováno v: Minerva urologica e nefrologica = The Italian journal of urology and nephrology. 56(2)

Multiple treatment options exist for men with non-metastatic prostate cancer. For nearly 50 years, external beam radiation therapy (EBRT) has been an important means of treating men with this disease. Improvements in technology and better use of pre-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd220c7b2fc440ce960015c5bc6c3a11
https://pubmed.ncbi.nlm.nih.gov/15195025

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Prevalence and patterns of self-initiated nutritional supplementation in men at high risk of prostate cancer

Autor: R G, Uzzo, J G, Brown, E M, Horwitz, A, Hanlon, S, Mazzoni, A, Konski, R E, Greenberg, A, Pollack, V, Kolenko, D, Watkins-Bruner

Publikováno v: BJU international. 93(7)

To define the prevalence and patterns of self-initiated herbal and vitamin supplementation among men at high risk of developing prostate cancer, as there is increasing public awareness of prostate cancer screening, risk-factor assessment and preventi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e744510eaaf4350893e0e65f8e7485c
https://pubmed.ncbi.nlm.nih.gov/15142142

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Defining the optimal radiation dose with three-dimensional conformal radiation therapy for patients with nonmetastatic prostate carcinoma by using recursive partitioning techniques

Autor: E M, Horwitz, A L, Hanlon, W H, Pinover, P R, Anderson, G E, Hanks

Publikováno v: Cancer. 92(5)

The objective of this study was to determine the effect of dose and its interaction with known prognostic variables, including pretreatment prostate specific antigen (PSA), Gleason score (GS), and T classification, on patients with nonmetastatic pros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cd742c8ca2895853e0f06b39178ca50
https://pubmed.ncbi.nlm.nih.gov/11571744

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Evidence for cure of 'young' men with prostate cancer

Autor: G E, Hanks, A L, Hanlon, E M, Horwitz

Publikováno v: Oncology (Williston Park, N.Y.). 15(5)

A study was undertaken to evaluate the question of cure in "young" men with prostate cancer treated by external-beam radiation. Results in young men (or = 65 years) were compared to older men. Biochemical freedom from failure was examined to 10 years

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f776ad2ed2cd6d068e4d643e4a91d3d
https://pubmed.ncbi.nlm.nih.gov/12108886

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Improved cerebrovascular patency following therapy in patients with sickle cell disease: initial results in 4 patients who received HLA-identical hematopoietic stem cell allografts

Autor: R G, Steen, K J, Helton, E M, Horwitz, E, Benaim, S, Thompson, L C, Bowman, R, Krance, W C, Wang, J M, Cunningham

Publikováno v: Annals of neurology. 49(2)

To test whether magnetic resonance angiography can document the evolution of vasculopathy in patients with sickle cell disease, we reviewed records to identify all patients who underwent magnetic resonance angiography from 1993 to 1999. Of 512 angiog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e65b5aa68fff6b45f9ed4601a91be05
https://pubmed.ncbi.nlm.nih.gov/11220742

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Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age: an Eppendorf pO(2) study

Autor: B, Movsas, J D, Chapman, R E, Greenberg, A L, Hanlon, E M, Horwitz, W H, Pinover, C, Stobbe, G E, Hanks

Publikováno v: Cancer. 89(9)

The purpose of this study was to analyze the extent of hypoxia in prostate carcinoma tumors using the Eppendorf pO(2) microelectrode and correlate this with pretreatment characteristics and prognostic factors.Custom-made Eppendorf pO(2) microelectrod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa2e42dc0e1e0fd5247f4fa08271179d
https://pubmed.ncbi.nlm.nih.gov/11064360

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