Zobrazeno 1 - 10 of 10 pro vyhledávání: '"E M, Garland"'
1
Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2)
Autor: I, Feoktistov, E M, Garland, A E, Goldstein, D, Zeng, L, Belardinelli, J N, Wells, I, Biaggioni
Publikováno v: Biochemical pharmacology. 62(9)
The antiasthmatic drug enprofylline was the first known selective, though not potent, A(2B) antagonist. On the basis of structure-activity relationships (SARs) of xanthine derivatives, we designed a novel selective adenosine A(2B) receptor antagonist
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50b2a992e2c4a9177b76a00d37e37049
https://pubmed.ncbi.nlm.nih.gov/11705449
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2
Effect of sodium saccharin on the neonatal rat bladder
Autor: S M, Cohen, M, Cano, M K, St John, E M, Garland, M, Khachab, L B, Ellwein
Publikováno v: Scanning microscopy. 9(1)
In a two-generation bioassay, high doses of dietary sodium saccharin (NaSac) produce bladder carcinoma in rats, whereas acid saccharin (HSac) does not effect the urothelium. NaSac and HSac administered as 5% of the diet to F0 Sprague-Dawley (SD) and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0182313732c4c2616d86a1f0a3f40b24
https://pubmed.ncbi.nlm.nih.gov/8553012
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4
Acrolein initiates rat urinary bladder carcinogenesis
Autor: S M, Cohen, E M, Garland, M, St John, T, Okamura, R A, Smith
Publikováno v: Cancer research. 52(13)
Acrolein, a reactive, alpha,beta-unsaturated aldehyde which is ubiquitous in the environment, forms DNA adducts, is mutagenic, and is teratogenic. However, studies have not indicated a carcinogenic effect in rodent bioassays. Since it is present in c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2f291654815eae9b4e22c62d0bac5e0
https://pubmed.ncbi.nlm.nih.gov/1617627
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6
H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts
Autor: T, Masui, A M, Mann, T L, Macatee, T, Okamura, E M, Garland, H, Fujii, J C, Pelling, S M, Cohen
Publikováno v: Cancer research. 51(13)
Male F344 rats were fed 0.2% N-[4-(5-nitro-2-furyl)-2-thiazoly]formamide for 6 weeks and then fed 3% or 5% sodium saccharin, 5% sodium ascorbate, 3.12% calcium saccharin, 1.34% sodium chloride, 5.2% calcium saccharin plus 1.34% sodium chloride, or ba
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5dfc8a210248f5b779fa4b42bd83855f
https://pubmed.ncbi.nlm.nih.gov/2054786
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7
Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet
Autor: T, Okamura, E M, Garland, T, Masui, T, Sakata, M, St John, S M, Cohen
Publikováno v: Cancer research. 51(7)
Sodium saccharin (NaSac) fed as 5% of Prolab diet promotes bladder tumor carcinogenesis in male F344 rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) fed as 0.2% of the diet for 4 weeks. NaSac also increases urothelial prolife
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83d0b292ae0225aabf2fb1cebf5679e0
https://pubmed.ncbi.nlm.nih.gov/2004361
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8
Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography
Autor: S M, Cohen, M J, Fisher, T, Sakata, M, Cano, G P, Schoenig, C I, Chappel, E M, Garland
Publikováno v: Scanning microscopy. 4(1)
Three methods used to detect proliferative changes in the rat urothelium, light microscopy, scanning electron microscopy, and autoradiography, were compared for their sensitivity in detecting changes produced by administration of sodium saccharin. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::870d6dd12ce852a9993ba65f4b4ac248
https://pubmed.ncbi.nlm.nih.gov/2367830
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9
Influences of diet and strain on the proliferative effect on the rat urinary bladder induced by sodium saccharin
Autor: E M, Garland, T, Sakata, M J, Fisher, T, Masui, S M, Cohen
Publikováno v: Cancer research. 49(14)
Rats were fed sodium saccharin as 5 or 7.5% of the diet by weight, and proliferation of the bladder epithelium was assessed by autoradiography, histology, and scanning electron microscopy. In Experiment 1, male F344 rats, 5 weeks old, were placed on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09819e5c1ff72529d6607f55a213a804
https://pubmed.ncbi.nlm.nih.gov/2736520
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10
Rat urinary bladder epithelial lesions induced by acrolein
Autor: T, Sakata, R A, Smith, E M, Garland, S M, Cohen
Publikováno v: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 9(2)
Acrolein, a constituent of cigarette smoke and a metabolite of cyclophosphamide, has been shown to induce acute cytotoxicity of the rat urinary bladder mucosa when instilled directly into the bladder lumen. To evaluate the effects of systemic adminis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0988cacd97db5a6fe38112a7dee20fe5
https://pubmed.ncbi.nlm.nih.gov/2732910
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