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LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation

Autor: C C, Felder, K E, Joyce, E M, Briley, M, Glass, K P, Mackie, K J, Fahey, G J, Cullinan, D C, Hunden, D W, Johnson, M O, Chaney, G A, Koppel, M, Brownstein

Publikováno v: The Journal of pharmacology and experimental therapeutics. 284(1)

LY320135 is a selective antagonist for the brain CB1 receptor, having greater than 70-fold higher affinity for the CB1 than the peripheral CB2 receptor. The Ki values for LY320135 at the CB1 and CB2 receptors, transfected and stably expressed in cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a8b913d1566d0484637fd768de640cc
https://pubmed.ncbi.nlm.nih.gov/9435190

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Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors

Autor: C C, Felder, K E, Joyce, E M, Briley, J, Mansouri, K, Mackie, O, Blond, Y, Lai, A L, Ma, R L, Mitchell

Publikováno v: Molecular pharmacology. 48(3)

The recently cloned CB2 cannabinoid receptor subtype was stably transfected into AtT-20 and Chinese hamster ovary cells to compare the binding and signal transduction properties of this receptor with those of the CB1 receptor subtype. The binding of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::989f7bcc160465ffbdd30d7371a2dbee
https://pubmed.ncbi.nlm.nih.gov/7565624

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Muscarinic acetylcholine receptor subtypes associated with release of Alzheimer amyloid precursor derivatives activate multiple signal transduction pathways

Autor: C C, Felder, A L, Ma, E M, Briley, J, Axelrod

Publikováno v: Annals of the New York Academy of Sciences. 695

Five subtypes of muscarinic acetylcholine receptors have been identified and designated m1-m5. The m1 and m3 receptors have recently been shown to stimulate APP processing. The m1 and m3 receptors couple to a variety of signal transduction pathways i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bd756c443ef0c83bf893602511236c
https://pubmed.ncbi.nlm.nih.gov/8239275

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Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones

Autor: C C, Felder, J S, Veluz, H L, Williams, E M, Briley, L A, Matsuda

Publikováno v: Molecular pharmacology. 42(5)

The physiologic activity of (-)-delta 9-tetrahydrocannabinol, the most active component of marijuana, and of many synthetic cannabimimetics may be mediated either through receptor binding and functional coupling to specific signal transduction pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cea5ee25b0a0b15b5b0b39e77e4b61c4
https://pubmed.ncbi.nlm.nih.gov/1331766

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Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells

Autor: R Y, Kanterman, L C, Mahan, E M, Briley, F J, Monsma, D R, Sibley, J, Axelrod, C C, Felder

Publikováno v: Molecular pharmacology. 39(3)

A rat D2L dopamine receptor, a splice variant of the D2 receptor, has recently been cloned. When transfected into and stably expressed in Chinese hamster ovary cells, these receptors mediate the inhibition of both basal and forskolin-stimulated cAMP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c152e7eddfbcfc667f2a7371543c3b4
https://pubmed.ncbi.nlm.nih.gov/1848657

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