Zobrazeno 1 - 10
of 101
pro vyhledávání: '"E Lucile White"'
Autor:
W Joon Chung, Jennifer L Goeckeler-Fried, Viktoria Havasi, Annette Chiang, Steven M Rowe, Zackery E Plyler, Jeong S Hong, Marina Mazur, Gary A Piazza, Adam B Keeton, E Lucile White, Lynn Rasmussen, Allan M Weissman, R Aldrin Denny, Jeffrey L Brodsky, Eric J Sorscher
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163615 (2016)
Small molecules that correct the folding defects and enhance surface localization of the F508del mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) comprise an important therapeutic strategy for cystic fibrosis lung disease. H
Externí odkaz:
https://doaj.org/article/5aa68f888e6b4637be0734ba8a6e6965
Autor:
Dong-Hoon Chung, Colleen B Jonsson, Nichole A Tower, Yong-Kyu Chu, Ergin Sahin, Jennifer E Golden, James W Noah, Chad E Schroeder, Julie B Sotsky, Melinda I Sosa, Daniel E Cramer, Sara N McKellip, Lynn Rasmussen, E Lucile White, Connie S Schmaljohn, Justin G Julander, Jeffrey M Smith, Claire Marie Filone, John H Connor, Yasuteru Sakurai, Robert A Davey
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004213 (2014)
Alphaviruses present serious health threats as emerging and re-emerging viruses. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, can cause encephalitis in humans and horses, but there are no therapeutics for treatment. To date, c
Externí odkaz:
https://doaj.org/article/18f656d9f91b4a0d9afd1e8d2f785905
Autor:
Carlos C Goller, Mehreen Arshad, James W Noah, Subramaniam Ananthan, Carrie W Evans, N Miranda Nebane, Lynn Rasmussen, Melinda Sosa, Nichole A Tower, E Lucile White, Benjamin Neuenswander, Patrick Porubsky, Brooks E Maki, Steven A Rogers, Frank Schoenen, Patrick C Seed
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e96054 (2014)
Uropathogenic Escherichia coli (UPEC) is the leading cause of community-acquired urinary tract infections (UTIs), with over 100 million UTIs occurring annually throughout the world. Increasing antimicrobial resistance among UPEC limits ambulatory car
Externí odkaz:
https://doaj.org/article/87e084b83fca45db96122f19cf43b049
Autor:
Qianjun Li, Shuang Feng, Marintha Heil, E. Lucile White, Subramaniam Ananthan, Blake. P. Moore, Sara N. McKellip, Clinton Maddox, Colleen B. Jonsson, Dong Hoon Chung, Lynn Rasmussen
Publikováno v:
Molecules, Vol 15, Iss 3, Pp 1690-1704 (2010)
West Nile virus (WNV) is a positive sense, single-stranded RNA virus that can cause illness in humans when transmitted via mosquito vectors. Unfortunately, no antivirals or vaccines are currently available, and therefore efficient and safe antivirals
Externí odkaz:
https://doaj.org/article/5c904eff5d7f424cbbe5b45e003c5992
Autor:
Justin A. Shapiro, Al Claiborne, Joanna B. Goldberg, Matthew R. Redinbo, E. Lucile White, Robert Bostwick, William M. Wuest, Derek Parsonage, John J. Varga, William G. Walton, Larry J. Ross
Publikováno v:
ChemMedChem. 14:78-82
Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug-resistant infections. Bacterial pantothenate kinase (PanK) has emerged as a target of interest to cut off the biosynthesis of coenzyme A. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3263e5d59e38bae6406a42d3261d6b
https://doi.org/10.1002/cmdc.201800652
https://doi.org/10.1002/cmdc.201800652
Autor:
Matan Rapaport, John L. Nitiss, Joe Madrey, Bogdan Polevoda, Gary A. Piazza, Michael Van Meter, David S. Goldfarb, Gregory Tombline, Krister Wennerberg, Lynn Rasmussen, Bonnie K. Baxter, E. Lucile White, Jonathan I. Millen, Matthew Gilbertson
Publikováno v:
Aging. 9:68-97
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c86da7ac32ccc0ccbd1ce3c2f14a0772
https://doi.org/10.18632/aging.101114
https://doi.org/10.18632/aging.101114
Autor:
E. Lucile White, Frank J. Schoenen, Jeffrey Aubé, Hendra Gunosewoyo, Haidan Guo, Clinton Maddox, Lynn Rasmussen, Shiqi Xiao, Warren S. Weiner, Shichun Lun, Shaaretha Pelly, Chunhong Mao, William R. Bishai
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
The suboptimal effectiveness of β-lactam antibiotics against Mycobacterium tuberculosis has hindered the utility of this compound class for tuberculosis treatment. However, the results of treatment with a second-line regimen containing meropenem plu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf78af77eb1cd354ae3cdb6db392458
https://doi.org/10.1128/aac.01319-19
https://doi.org/10.1128/aac.01319-19
Autor:
Min Li, Hugh Rosen, Donghoon Chung, Owen B. McManus, Shaun R. Stauffer, Thomas D.Y. Chung, P. Jeffrey Conn, Stuart L. Schreiber, Michael R. Jackson, Jennifer E. Golden, Andrea de Souza, Edward Roberts, Joanne Kotz, Christopher P. Austin, William Severson, Patrick R. Griffin, Subramaniam Ananthan, Mathias J. Wawer, Alykhan F. Shamji, Tudor I. Oprea, Ajit Jadhav, Frank J. Schoenen, Michael R. Wood, Anton Simeonov, Michael Foley, Haibo Yu, Peter Hodder, Jeffrey Aubé, William R. Roush, Benjamin Alexander, E. Lucile White, Benjamin F. Cravatt, Joshua A. Bittker, James W. Noah, Beiyan Zou, Kyle A. Emmitte, Meng Wu, John C. Reed, Corey R. Hopkins, Colleen B. Jonsson, Anthony B. Pinkerton, Larry A. Sklar, Michelle Palmer, Craig W. Lindsley, Paul A. Clemons, Bruce S. Edwards
Publikováno v:
Cell. 161:1252-1265
Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous promise of chemical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c63d6674264edc9195e8979c881450
https://doi.org/10.1016/j.cell.2015.05.023
https://doi.org/10.1016/j.cell.2015.05.023
Autor:
Marie K. Mankowski, N. Miranda Nebane, Andrew Jay Brazier, Sara J. Buhrlage, Vikas Misra, Dana Gabuzda, Erez Pery, Roger G. Ptak, Lynn Rasmussen, Kottampatty S. Rajendran, Ann M. Sheehy, E. Lucile White
Publikováno v:
Journal of Biological Chemistry. 290:10504-10517
APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermutation in viral DNA and by deamination-independent mechanisms. HIV-1 Vif binds to A3G, resulting in its degradation via the 26 S proteasome. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db3565ad06467fd86deade1aa0992fb
https://doi.org/10.1074/jbc.m114.626903
https://doi.org/10.1074/jbc.m114.626903
Autor:
Alexander Bukreyev, Lynn Rasmussen, James W. LeDuc, James W. Noah, E. Lucile White, Nichole A. Tower, Barry Rockx, Robert Bostwick, Bersabeh Tigabu
Publikováno v:
ASSAY and Drug Development Technologies
High-throughput screening (HTS) has been integrated into the drug discovery process, and multiple assay formats have been widely used in many different disease areas but with limited focus on infectious agents. In recent years, there has been an incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081d2c91c1852f52fb542b277f940a78