Zobrazeno 1 - 10
of 264
pro vyhledávání: '"E Lucente"'
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
Autor:
M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine A Donovan, Ghata Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty
Publikováno v:
eLife, Vol 8 (2019)
Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas. Positron emission tomography (PET) tracers that bind to pathological tau are used in diagnosis, but
Externí odkaz:
https://doaj.org/article/61644ae2e0484e5e9ce5e832e02c1ee1
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ping-Chieh Pao, Jinsoo Seo, Audrey Lee, Oleg Kritskiy, Debasis Patnaik, Jay Penney, Ravikiran M. Raju, Ute Geigenmuller, M. Catarina Silva, Diane E. Lucente, James F. Gusella, Bradford C. Dickerson, Anjanet Loon, Margaret X. Yu, Michael Bula, Melody Yu, Stephen J. Haggarty, Li-Huei Tsai
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product p25, leading to prolonged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f59bcb292e1d1b5c3991d1c46aa356d
https://doi.org/10.1073/pnas.2217864120
https://doi.org/10.1073/pnas.2217864120
Autor:
Julio C. Rojas, Hilary W. Heuer, Weiping Chen, Julie Czerkowicz, Danielle Graham, Leah K. Forsberg, Danielle Brushaber, Brian Appleby, Eliana Marisa Ramos, Giovanni Coppolla, Yvette M. Bordelon, Hugo Botha, Brad C. Dickerson, Dennis W. Dickson, Kimiko Domoto‐Reilly, Anne M. Fagan, Julie A. Fields, Jamie C. Fong, Tatiana M. Foroud, Doug R. Galasko, Ralitza H. Gavrilova, Daniel H. Geschwind, Nupur Ghoshal, Jill Goldman, Neill R. Graff‐Radford, Jonathan Graff‐Radford, Ian Grant, Murray Grossman, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward D. Huey, David J. Irwin, David T. Jones, Kejal Kantarci, David S. Knopman, John Kornak, Walter K. Kremers, Maria I. Lapid, Gabriel C. Leger, Irene Litvan, Peter A. Ljubenkov, Diane E. Lucente, Ian R Mackenzie, Joseph C. Masdeu, Corey T. McMillan, Mario F. Mendez, Bruce L. Miller, Toji Miyagawa, Chiadi U. Onyike, Belen Pascual, Otto Pedraza, Leonard Petrucelli, Rosa Rademakers, Katherine P. Rankin, Katya Rascovsky, Jessica E. Rexach, Aaron Ritter, Erik D. Roberson, Rodolfo Savica, William W. Seeley, Adam M. Staffaroni, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Lawren Vandevrede, Bradley F. Boeve, Howard J. Rosen, Adam L. Boxer
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ba5ff64ac03f24ac019cbc56adec4c
https://doi.org/10.1002/alz.052993
https://doi.org/10.1002/alz.052993
Autor:
Julio C. Rojas, Lawren Vandevrede, Hilary W. Heuer, Gianina Toller, Elisabeth H. Thijssen, Nicholas Proctor, Leah K. Forsberg, Danielle Brushaber, Eliana Marisa Ramos, Giovanni Coppola, Brian Appleby, Yvette M. Bordelon, Hugo Botha, Brad C. Dickerson, Dennis W. Dickson, Kimiko Domoto‐Reilly, Anne M. Fagan, Julie A. Fields, Jamie C. Fong, Tatiana M. Foroud, Doug R. Galasko, Ralitza H. Gavrilova, Daniel H. Geschwind, Nupur Ghoshal, Jill Goldman, Neill R. Graff‐Radford, Jonathan Graff‐Radford, Ian Grant, Murray Grossman, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward D. Huey, David J. Irwin, David T. Jones, Kejal Kantarci, David S. Knopman, John Kornak, Walter K. Kremers, Maria I. Lapid, Gabriel C. Leger, Irene Litvan, Peter A. Ljubenkov, Diane E. Lucente, Ian R. Mackenzie, Joseph C. Masdeu, Corey T. McMillan, Mario Mendez, Bruce L. Miller, Toji Miyagawa, Chiadi U. Onyike, Belen Pascual, Otto Pedraza, Leonard Petrucelli, Rosa Rademakers, Katherine P. Rankin, Katya Rascovsky, Jessica E. Rexach, Aaron Ritter, Erik D. Roberson, Rodolfo Savica, William W. Seeley, Adam M. Staffaroni, Maria Carmela Trataglia, Arthur W. Toga, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Jeffrey L. Dage, Bradley F. Boeve, Howard J. Rosen, Adam L. Boxer
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc26c5630e6585daa65c282a7eae88fc
https://doi.org/10.1002/alz.055763
https://doi.org/10.1002/alz.055763
Publikováno v:
Journal of Environmental Management. 151:427-436
We examine sensitivity of estimates of recreation demand using the Travel Cost Method (TCM) to four factors. Three of the four have been routinely and widely discussed in the TCM literature: a) Poisson verses negative binomial regression; b) applicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8179c5328b77302c2d58207c4cc4c6
https://doi.org/10.1016/j.jenvman.2014.12.033
https://doi.org/10.1016/j.jenvman.2014.12.033
Publikováno v:
Fisheries. 37:532-541
Charter fishing provides important angler access to Lake Erie sport fishing. It is economically important to local harbor communities, with 79% of charter anglers coming from over 50 miles away. To update information from our 2006 survey, we conducte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b5e315a8761a553f5eed082fdfc06d9
https://doi.org/10.1080/03632415.2012.742805
https://doi.org/10.1080/03632415.2012.742805
Publikováno v:
The Laryngoscope. 121:661-666
Eustachian tube dysfunction (ETD) is a common condition that lacks a widely accepted treatment. Attempts to address ETD surgically have spanned several centuries and have often fallen short of success. It is probable that occult anatomic position, un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b6a2795a2d2b8364b0dfd3632cc9b4
https://doi.org/10.1002/lary.21453
https://doi.org/10.1002/lary.21453
Autor:
A. Peris, Stefano Batacchi, Francesco Barbani, Maria Boddi, M. Chiostri, M. Bonizzoli, E Lucente, G.F. Gensini, Rosanna Abbate
Publikováno v:
Journal of Thrombosis and Haemostasis. 8:121-128
Summary. Background: Deep vein thrombosis (DVT) is a major complication in intensive care units (ICU) but dedicated guidelines on its management are still lacking. Objectives and Methods: This study investigated the effect of a 1-year educational pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c65cfe2b93e0f232d6c7de377a3502
https://doi.org/10.1111/j.1538-7836.2009.03664.x
https://doi.org/10.1111/j.1538-7836.2009.03664.x