Zobrazeno 1 - 10
of 1 152
pro vyhledávání: '"E Leysen"'
Autor:
Athanasios Metaxas, Bart N. M. van Berckel, Pieter J. Klein, Joost Verbeek, Emily C. Nash, Esther J. M. Kooijman, Véronique A. Renjaän, Sandeep S. V. Golla, Ronald Boellaard, Johannes A. M. Christiaans, Albert D. Windhorst, Josée E. Leysen
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 1, Pp n/a-n/a (2019)
Abstract Labeled with carbon‐11, N‐(2‐chloro‐5‐thiomethylphenyl)‐N′‐(3‐methoxyphenyl)‐N′‐methylguanidine ([11C]GMOM) is currently the only positron emission tomography (PET) tracer that has shown selectivity for the ion‐chan
Externí odkaz:
https://doaj.org/article/d526cd10484549bca728a435a4c3653a
Autor:
Athanasios, Metaxas, Bart N M, van Berckel, Pieter J, Klein, Joost, Verbeek, Emily C, Nash, Esther J M, Kooijman, Véronique A, Renjaän, Sandeep S V, Golla, Ronald, Boellaard, Johannes A M, Christiaans, Albert D, Windhorst, Josée E, Leysen
Publikováno v:
Pharmacology Research & Perspectives
Labeled with carbon‐11, N‐(2‐chloro‐5‐thiomethylphenyl)‐N′‐(3‐methoxyphenyl)‐N′‐methylguanidine ([11C]GMOM) is currently the only positron emission tomography (PET) tracer that has shown selectivity for the ion‐channel site
Autor:
Pieter J. Klein, Athanasios Metaxas, Josée E. Leysen, Roland Willems, B.N.M. van Berckel, V.A. Renjaän, Albert D. Windhorst, Esther J.M. Kooijman, L. Ver Donck
Publikováno v:
Journal of Neuroscience Research. 92:1599-1607
Although both the onset of schizophrenia and human phencyclidine (PCP) abuse typically present within the interval from adolescence to early adulthood, the majority of preclinical research employing the PCP model of schizophrenia has been conducted o
Autor:
Pieter J. Klein, Albert D. Windhorst, Josée E. Leysen, Adriaan A. Lammertsma, Athanasios Metaxas, Robert C. Schuit, Bart N.M. van Berckel, Esther J.M. Kooijman, Johannes A. M. Christiaans
Publikováno v:
Nuclear Medicine and Biology, 41(8), 670-680. Elsevier Inc.
Christiaans, J A M, Klein, P J, Metaxas, A, Kooijman, E J M, Schuit, R C, Leysen, J E, Lammertsma, A A, van Berckel, B N M & Windhorst, A D 2014, ' Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[C-11]methoxyphenyl) pyridin-3-yl) methyl) cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors ', Nuclear Medicine and Biology, vol. 41, no. 8, pp. 670-680 . https://doi.org/10.1016/j.nucmedbio.2014.04.131
Christiaans, J A M, Klein, P J, Metaxas, A, Kooijman, E J M, Schuit, R C, Leysen, J E, Lammertsma, A A, van Berckel, B N M & Windhorst, A D 2014, ' Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[C-11]methoxyphenyl) pyridin-3-yl) methyl) cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors ', Nuclear Medicine and Biology, vol. 41, no. 8, pp. 670-680 . https://doi.org/10.1016/j.nucmedbio.2014.04.131
Introduction The N-methyl-D-Aspartate (NMDA) receptor plays an important role in learning and memory. Overactivation is thought to play an important role in neurodegenerative disorders such as Alzheimer's disease. Currently, it is not possible to ass
Autor:
Ronald Boellaard, Emily C. Nash, Esther J.M. Kooijman, Josée E. Leysen, Albert D. Windhorst, Pieter J. Klein, Athanasios Metaxas, Véronique A. Renjaän, Joost Verbeek, Bart N.M. van Berckel, Sandeep S.V. Golla, Johannes A. M. Christiaans
Publikováno v:
Pharmacology Research & Perspectives. 7:e00458
Labeled with carbon-11, N-(2-chloro-5-thiomethylphenyl)-N'-(3-methoxyphenyl)-N'-methylguanidine ([11 C]GMOM) is currently the only positron emission tomography (PET) tracer that has shown selectivity for the ion-channel site of N-methyl-D-aspartate (
Autor:
Pieter Annaert, Herman Borghys, Josée E. Leysen, Roger Carolus Augusta Embrechts, Guillaume Michel Joseph Mauric, Piet Herdewijn, Loeckie de Zwart, Ronald de Vries, John R. Atack, Tim Gaekens, Angelo Vermeulen, Anton Megens
Nalmefene is an opioid antagonist which as a once-a-day tablet formulation has recently been approved for reducing ethanol intake in alcoholic subjects. In order to address the compliance issue in this patient population, a number of potential nalmef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1c03a8b5dcd2b7214ca93918853e42
Autor:
Hans Jc Buiter, Abraham Fisher, Albert D. Windhorst, Robert C. Schuit, Adriaan A. Lammertsma, Josée E. Leysen
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:264-273
Purpose M1 muscarinic acetylcholine receptor (M1ACh-R) agonists are potential therapeutics for cognitive disorders. The aim of this study was to develop an orthosteric agonist positron emission tomography (PET) ligand for the M1ACh-R that would provi
Autor:
D. van der Born, Josée E. Leysen, R. al Hussainy, R.J. Knol, Jacobus D. M. Herscheid, A.H. Braker, Jan Booij, Joost Verbeek
Publikováno v:
Journal of Medicinal Chemistry. 54:3480-3491
Here we describe the design, synthesis, and pharmacological profile of 5-HT1A receptor ligands related to 1 (WAY-100635). The cyclohexyl moiety in 1 and its O-desmethylated analogue 3 were replaced by the bridgehead iodinated bridge-fused rings: adam
Autor:
Thomas H. Kramer, Dirk Tourwé, J. Couder, D. Meert, Peg Davis, Thomas F. Burks, J. E. Leysen, M. Ceusters, Henry I. Yamamura, Georges Van Binst, Richard J. Knapp
Publikováno v:
International Journal of Peptide and Protein Research. 39:131-136
The peptide CO-NH function was replaced by a trans carbon-carbon double bond or by a CH2-CH2 isostere in enkephalin analogues of DADLE, DCDCE-NH2 or DPDPE. In DADLE the 2-3 and the 3-4 peptide bond was modified, whereas in the cyclic analogues the Gl
Publikováno v:
International Journal of Peptide and Protein Research. 41:181-184
Each peptide CO-NH function in the biologically important C-terminal 8-13 sequence of neurotensin was replaced by the reduced CH 2 -NH isostere using the rapid in situ solid phase procedure developed by Sasaki & Coy. In general this modification resu