Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill

Autor: Olga Eguaogie, Patrick F. Conlon, Francesco Ravalico, Jamie S. T. Sweet, Thomas B. Elder, Louis P. Conway, Marc E. Lennon, David R. W. Hodgson, Joseph S. Vyle

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 87-92 (2017)

Vibration ball-milling in a zirconia-lined vessel afforded clean and quantitative nucleophilic displacement reactions between 4-methoxybenzylthiolate salts and nucleoside 5′-halides or 5′-tosylates in five to 60 minutes. Under these conditions, c

Externí odkaz: https://doaj.org/article/6d3b6b6007ef41de80e4fea654d64978

HABP2 is a novel regulator of hyaluronan-mediated human lung cancer progression

Autor: Tamara eMirzapoiazova, Nurbek eMambetsariev, Frances E. Lennon, Bolot eMambetsariev, Joshua E. Berlind, Ravi eSalgia, Patrick A. Singleton

Publikováno v: Frontiers in Oncology, Vol 5 (2015)

Background: Lung cancer is a devastating disease with limited treatment options. Many lung cancers have changes in their microenvironment including upregulation of the extracellular matrix glycosaminoglycan, hyaluronan (HA), which we have previously

Externí odkaz: https://doaj.org/article/e8ab121801524071a7baddc9f70f8d49

The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer.

Autor: Frances E Lennon, Tamara Mirzapoiazova, Bolot Mambetsariev, Valeriy A Poroyko, Ravi Salgia, Jonathan Moss, Patrick A Singleton

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91577 (2014)

Recent epidemiologic studies implying differences in cancer recurrence based on anesthetic regimens raise the possibility that the mu opioid receptor (MOR) can influence cancer progression. Based on our previous observations that overexpression of MO

Externí odkaz: https://doaj.org/article/3c0a1cd04ee348288ced2936d5436c32

Author response for 'Metformin and carotid intima media thickness in never smokers with type 1 diabetes: the REMOVAL trial'

Autor: null JG Timmons, null N Greenlaw, null JG Boyle, null N Chaturvedi, null I Ford, null MCGJ Brouwers, null T Tillin, null I Hramiak, null AD Hughes, null AJ Jenkins, null BEK Klein, null R Klein, null TC Ooi, null P Rossing, null CDA Stehouwer, null N Sattar, null HM Colhoun, null JR Petrie, null A Hughes, null A Jenkins, null H Nickerson, null O Lou, null S Dutta, null Jonathan Haw, null Carol Anderson, null S Kean, null E Thomson, null L Gillespie, null J Gibb, null A Keech, null K March, null S Williams, null E Coady, null M Bots, null B Klein, null J Dreyer, null T Jan, null Koby Sheffy, null Ravit Lusky, null Shlomit Peleg, null J Petrie, null H Colhoun, null A Shore, null D Carty, null P Donnan, null M Witham, null A Adler, null E Lonn, null P Rauchhaus, null R Lindsay, null M Brouwers, null J Van‐Melckebeke, null T Hamill, null L Cuthbertson, null A Murray, null L Jolly, null E Miller, null J Hair, null A Bell, null S Carmichael, null E Douglas, null P Surtees, null E Dinnett, null J Allan, null C Watson, null M McLaughlin, null G Brindley, null E Smillie, null D Motherwell, null S MacDonald, null P Ellis, null D Stuart, null M Travers, null S Brearley, null L Greig, null P Colman, null D West, null S Vaughan, null M Bjorasen, null J Donlan, null J Vrazas, null D O'Neal, null J Horsburgh, null S Kent, null S Twigg, null G Fulcher, null R Denner, null A Piotrowicz, null A Januszewski, null H Pater, null A Coy, null T Paul, null C McDonald, null S Tereschyn, null N Schmidt, null M Weingert, null H Heard, null S Burke, null H Lochnan, null A Sorisky, null E Keely, null J Malcolm, null J Maranger, null C Favreau, null S Petherick, null K Boles, null TW Hansen, null B Hemmingsen, null N Thorogood, null K Green, null T Robinson, null K Abouglilia, null D Nayman, null C Miller, null R Warren, null K Aizawa, null M Balasubramani, null S Toth, null K Harvey, null G Birch, null T Sathyapalan, null A James, null Z Javed, null J Wilding, null B Martin, null S Birch, null A Wilcox, null N Watson, null N Oliver, null N Jugnee, null M Rutter, null T Turgut, null A Shaju, null S Yau, null S Subin, null M Walker, null D Wake, null A Millward, null P Chong, null M Hibbert, null N Schaper, null J Pinxt, null S Philip L Murray, null Linda Sleigh, null K Allan, null J Cook, null K Campbell, null L Hodge, null G Leese, null G Reekie, null K Shields, null A Jaap, null A Sudworth, null A White, null J McKnight, null L Steven, null G McKay, null A Llano, null G Currie, null E Lennon, null J Johnstone, null for the REMOVAL Study Group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55b8ba92b6d72b6e2e19fc362141545d
https://doi.org/10.1111/dom.14350/v2/response1

Enantioselective synthesis of ammonium cations

Autor: Joseph M. Phelps, Mark P. Walsh, Marc E. Lennon, Matthew O. Kitching, Dmitry S. Yufit

Publikováno v: Nature. 597(7874)

Control of molecular chirality is a fundamental challenge in organic synthesis. Whereas methods to construct carbon stereocentres enantioselectively are well established, routes to synthesize enriched heteroatomic stereocentres have garnered less att

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00643ffd9b20dad87725c5d175bf8a8
https://pubmed.ncbi.nlm.nih.gov/34471272