Výsledky vyhledávání - "E Lake, Potter"

Akademický článek

Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining

Autor: Ryland D. Mortlock, Chuanfeng Wu, E. Lake Potter, Diana M. Abraham, David S. J. Allan, So Gun Hong, Mario Roederer, Cynthia E. Dunbar

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

The in vivo tissue distribution and trafficking patterns of natural killer (NK) cells remain understudied. Animal models can help bridge the gap, and rhesus macaque (RM) primates faithfully recapitulate key elements of human NK cell biology. Here, we

Externí odkaz: https://doaj.org/article/34dbcd3433c44832ab86cf43b56e3e52

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Akademický článek

Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)

Externí odkaz: https://doaj.org/article/05cda4cb9225447c85e4cdf802228026

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Akademický článek

Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies

Autor: Cheng Zhu, Elena Dukhovlinova, Olivia Council, Lihua Ping, Edgar M. Faison, Shamit S. Prabhu, E. Lake Potter, Stephen L. Upton, Guowei Yin, James M. Fay, Laura P. Kincer, Ean Spielvogel, Sharon L. Campbell, S. Rahima Benhabbour, Hengming Ke, Ronald Swanstrom, Nikolay V. Dokholyan

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Areas of HIV envelope (Env) that aren’t covered by glycans are potential targets for antibodies. Here, the authors computationally design small protein mimics of four such epitopes and show that they can induce Env binding antibodies in rabbits.

Externí odkaz: https://doaj.org/article/e4e26a3dfbec4915bf069d55e9f14cb0

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Supplementary Table S3 from IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

Autor: Thomas A. Waldmann, Mario Roederer, Stephen P. Creekmore, Jason L. Yovandich, Joanna H. Shih, Cody J. Peer, William D. Figg, Jennifer Hsu, Liyanage P. Perera, Michael Petrus, Bonita R. Bryant, Sigrid Dubois, Thomas A. Fleisher, Milos D. Miljkovic, Chyi-Chia Richard Lee, Stefania Pittaluga, E. Lake Potter, Kevin C. Conlon

Supplementary Table S3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1bf1c000cdaa5e45163768f14b90ad
https://doi.org/10.1158/1078-0432.22472925

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Figure S2 from IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

Supplementary Figure S2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd7ee296ed768898d0927feed11daee
https://doi.org/10.1158/1078-0432.22472958

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Supplementary Data from IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

Supplementary Data (Tracking)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3950620d876ff80b11022940ee60e6c
https://doi.org/10.1158/1078-0432.22472937

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Data from IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

Purpose:The first-in-human clinical trial with human bolus intravenous infusion IL15 (rhIL15) was limited by treatment-associated toxicity. Here, we report toxicity, immunomodulation, and clinical activity of rhIL15 administered as a 10-day continuou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c59bd9e44049b887a568fab0a909f2
https://doi.org/10.1158/1078-0432.c.6528375

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Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 + T cells drive gastrointestinal acute graft-versus-host disease

Publikováno v: Science Translational Medicine. 13

Organ infiltration by donor T cells is critical to the development of acute graft-versus-host disease (aGVHD) in recipients after allogeneic hematopoietic stem cell transplant (allo-HCT). However, deconvoluting the transcriptional programs of newly r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c14cb445ad051d65e35dc4b99686da54
https://doi.org/10.1126/scitranslmed.abc0227

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Akademický článek

Comparison of SIV and HIV-1 genomic RNA structures reveals impact of sequence evolution on conserved and non-conserved structural motifs.

Autor: Elizabeth Pollom, Kristen K Dang, E Lake Potter, Robert J Gorelick, Christina L Burch, Kevin M Weeks, Ronald Swanstrom

Publikováno v: PLoS Pathogens, Vol 9, Iss 4, p e1003294 (2013)

RNA secondary structure plays a central role in the replication and metabolism of all RNA viruses, including retroviruses like HIV-1. However, structures with known function represent only a fraction of the secondary structure reported for HIV-1(NL4-

Externí odkaz: https://doaj.org/article/c7fbf127bb35497698167c323407e350

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