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Evaluation of a live attenuated, cold-adapted parainfluenza virus type 3 vaccine in children

Autor: Fran Newman, Sharon L. Nugent, Robert B. Belshe, Edwin L. Anderson, M H Wilson, S L Hall, E L Tierney, M Steinhoff, M L Clements, R A Karron

Publikováno v: Journal of Clinical Microbiology. 30:2064-2070

Cold passage 18 (CP18) parainfluenza virus type 3 (PIV-3) vaccine was evaluated in a double-blind, randomized, placebo-controlled study of 95 infants and young children. None of 19 seropositive older children 41 to 124 months old became infected when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df6e406f2e936c1a1d18eb82ad7c971
https://doi.org/10.1128/jcm.30.8.2064-2070.1992

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Evaluation of bovine, cold-adapted human, and wild-type human parainfluenza type 3 viruses in adult volunteers and in chimpanzees

Autor: Mary Lou Clements, Brian R. Murphy, F Newman, T U Westblom, J King, W T London, E L Tierney, R B Belshe

In an attempt to evaluate the level of attenuation of live parainfluenza type 3 virus (PIV3) vaccine candidates, we compared the responses of partially immune adult volunteers inoculated intranasally with 10(6) to 10(7) 50% tissue culture infective d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb29b58ee9321622e9c0da63ea5a49d
https://europepmc.org/articles/PMC269965/

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Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines

Autor: Dan C. DeBorde, Hunein F. Maassab, Robert F. Betts, Brian R. Murphy, Stephen D. Sears, D Herrington, M L Clements, M H Snyder, Raphael Dolin, E L Tierney

Publikováno v: Journal of Virology. 62:488-495

Clinical studies previously demonstrated that live influenza A virus vaccines derived by genetic reassortment from the mating of influenza A/Ann Arbor/6/60 (H2N2) cold-adapted (ca) donor virus with epidemic wild-type influenza A viruses are reproduci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19875cd3bf0aaabb13e8543b20473d09
https://doi.org/10.1128/jvi.62.2.488-495.1988

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Evaluation of live avian-human reassortant influenza A H3N2 and H1N1 virus vaccines in seronegative adult volunteers

Autor: Raphael Dolin, M H Snyder, Robert F. Betts, E L Tierney, Brian R. Murphy, M L Clements, A J Buckler-White

Publikováno v: Journal of Clinical Microbiology. 23:852-857

An avian-human reassortant influenza A virus deriving its genes coding for the hemagglutinin and neuraminidase from the human influenza A/Washington/897/80 (H3N2) virus and its six "internal" genes from the avian influenza A/Mallard/NY/6750/78 (H2N2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51908f5633d6e10b36c1bda67ec4641
https://doi.org/10.1128/jcm.23.5.852-857.1986

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Response of seronegative and seropositive adult volunteers to live attenuated cold-adapted reassortant influenza A virus vaccine

Autor: Brian R. Murphy, E L Tierney, M L Clements

Publikováno v: Journal of Clinical Microbiology. 21:997-999

The infectivity and immunogenicity of live attenuated A/Washington/897/80 cold-adapted reassortant virus vaccine was evaluated in seronegative (hemagglutination inhibition titer, less than or equal to 1:4) and seropositive (hemagglutination inhibitio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb3fa87778dc2ba681a431e3d2920ba
https://doi.org/10.1128/jcm.21.6.997-999.1985

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Temperature-sensitive mutants of influenza. VIII. Genetic and biological characterization of TS mutants of influenza virus A (H3N2) and their assignment to complementation groups

Autor: S B, Spring, S R, Nusinoff, E L, Tierney, D D, Richman, B R, Murphy, R M, Chanock

Publikováno v: Virology. 66(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64086dcb546d78c2d7f2f766a994cc8c
https://pubmed.ncbi.nlm.nih.gov/1154652

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Specificity of the local secretory antibody to influenza A virus infection

Autor: D D, Richman, B R, Murphy, E L, Tierney, R M, Chanock

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 113(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3f670c18449415388103dc7c718a941
https://pubmed.ncbi.nlm.nih.gov/4213978

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Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus

Autor: M L Clements, Brian R. Murphy, E L Tierney, Robert F. Betts

To identify immunological predictors of resistance to influenza A infection and illness, the immunological status of live and inactivated virus vaccines subsequently challenged with H1N1 or H3N2 wild-type virus was examined. We refer to prechallenge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c81b0c04a4d4be46f208ea45b7380d
https://europepmc.org/articles/PMC268857/

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Temperature-sensitive mutants of influenza A virus. XI. Transfer of ts lesions in the Hong Kong/68-ts-1 [a] virus to the influenza A/Udorn/72 wild type

Autor: B R, Murphy, E L, Tierney, S B, Spring, R M, Chanock

Publikováno v: The Journal of infectious diseases. 134(6)

The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups 1 and 5 in the Hong Kong/68-ts-1[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kong/68-ts-1[A] virus and a Udorn/72 wild-type v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7588257bd52612e6f14172d2fdd0fb1b
https://pubmed.ncbi.nlm.nih.gov/1003013

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