Zobrazeno 1 - 10
of 34
pro vyhledávání: '"E L, Saenko"'
Publikováno v:
Haemophilia. 10:133-139
Technologies in molecular biology have greatly advanced the knowledge regarding the origin of haemophilia A and the physiology of the factor VIII (FVIII) protein. A variety of different mutations in the FVIII gene have been identified and their effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117e0787cca22f3e1a43bc12fc9f8b53
https://doi.org/10.1111/j.1365-2516.2004.01005.x
https://doi.org/10.1111/j.1365-2516.2004.01005.x
Autor:
E. L. Saenko, J. A. M. Anderson
Publikováno v:
British Journal of Anaesthesia. 88:467-469
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2d11eac5480b082b3ad308f33c7b80
https://doi.org/10.1093/bja/88.4.467
https://doi.org/10.1093/bja/88.4.467
Autor:
E. L. Saenko
Publikováno v:
36th Hemophilia Symposium Hamburg 2005 ISBN: 9783540367147
The present review discusses the current concept of receptor-mediated clearance of coagulation factor VIII (FVIII) from the circulation in vivo, which is one of the mechanisms regulating FVIII level in plasma. Several lines of experimental evidence s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae9635fc360fa31012f80146f050496
https://doi.org/10.1007/978-3-540-36715-4_4
https://doi.org/10.1007/978-3-540-36715-4_4
Autor:
E L, Saenko, N, Ananyeva, D, Kouiavskaia, H, Schwinn, D, Josic, M, Shima, C A E, Hauser, S, Pipe
Publikováno v:
Vox sanguinis. 83(2)
Molecular defects in Factor VIII (FVIII), such as haemophilia A-related mutations or denaturative conformational changes, may affect the stability of FVIII as well as its interactions with physiological activators, von Willebrand Factor, phospholipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec8bf387e79bc24cf19ab82ba9121f8d
https://pubmed.ncbi.nlm.nih.gov/12201837
https://pubmed.ncbi.nlm.nih.gov/12201837
Autor:
J A M, Anderson, E L, Saenko
Publikováno v:
British journal of anaesthesia. 88(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50b7f5b440afd17713a7940d7ff75553
https://pubmed.ncbi.nlm.nih.gov/12402738
https://pubmed.ncbi.nlm.nih.gov/12402738
Publikováno v:
Doklady. Biochemistry and biophysics. 383
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62e5dd3bfa984302e3fedd960bfe62cd
https://pubmed.ncbi.nlm.nih.gov/12058364
https://pubmed.ncbi.nlm.nih.gov/12058364
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 8(2)
Haemophilia A is the most common inherited bleeding disorder, caused by a deficiency in coagulation factor VIII (FVIII). Current treatment of haemophilia A is based on repeated infusions of plasma-derived FVIII concentrate or of recombinant FVIII, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6222bd4f97516134bb218e3132c54483
https://pubmed.ncbi.nlm.nih.gov/11952840
https://pubmed.ncbi.nlm.nih.gov/11952840
Autor:
E L, Saenko, N M, Ananyeva, D V, Kouiavskaia, A V, Khrenov, J A M, Anderson, M, Shima, J, Qian, D, Scott
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 8(1)
Factor VIII (FVIII) is an essential component of the intrinsic pathway of blood coagulation. Normal functioning of FVIII requires its interactions with other components of the coagulation cascade. In the circulation, it exists as a complex with von W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fa2115b043c30ae62a2e1790322cdc6
https://pubmed.ncbi.nlm.nih.gov/11886458
https://pubmed.ncbi.nlm.nih.gov/11886458
Autor:
D, David, E L, Saenko, I M, Santos, D J, Johnson, E G, Tuddenham, J H, McVey, G, Kemball-Cook
Publikováno v:
British journal of haematology. 113(3)
In haemophilia A, the functional defect at the molecular level of most factor VIII (FVIII) missense mutations remains unknown. Site-directed mutagenesis of B domain-deleted FVIII cDNA (FVIIISQ) was used to introduce two mutations associated with seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f6ce7cc932d94345e869b68fb468207
https://pubmed.ncbi.nlm.nih.gov/11380445
https://pubmed.ncbi.nlm.nih.gov/11380445
Autor:
K, Nogami, M, Shima, H, Nakai, I, Tanaka, H, Suzuki, S, Morichika, M, Shibata, E L, Saenko, D, Scandella, J C, Giddings, A, Yoshioka
Publikováno v:
British journal of haematology. 107(1)
Factor VIII (FVIII) inhibitor alloantibodies react with combinations of the A2, C2 and A3-C1 domains of the FVIII molecule. Some inhibitors block binding of FVIII to both von Willebrand factor (VWF) and phospholipid, and recognize a C2 domain epitope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a1566cc36028f250ec544e99e6b082d
https://pubmed.ncbi.nlm.nih.gov/10520041
https://pubmed.ncbi.nlm.nih.gov/10520041