Zobrazeno 1 - 10 of 27 pro vyhledávání: '"E Koeneke"'
2
The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines
Autor: Nikolas Gunkel, Manfred Jung, Tino Heimburg, Fiona R. Kolbinger, E Koeneke, Frank Westermann, Johannes Ridinger, Michael W. Müller, Theresa Bayer, Ina Oehme, Wolfgang Sippl, Aubry K. Miller, Olaf Witt
Publikováno v: Archives of Toxicology
High histone deacetylase (HDAC) 8 and HDAC10 expression levels have been identified as predictors of exceptionally poor outcomes in neuroblastoma, the most common extracranial solid tumor in childhood. HDAC8 inhibition synergizes with retinoic acid t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2224347a7fc89bf54ace597034f75773
https://doi.org/10.1007/s00204-018-2234-8
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3
A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment
Autor: E Koeneke, Olaf Witt, Sara Najafi, Frank Westermann, Benjamin Meder, Manfred Jung, Fiona R. Kolbinger, Martin Distel, Johannes Fabian, Ina Oehme, Sina Stäble, Dominique Kranz, Tino Heimburg, Heike Peterziel, Wolfgang Sippl, Jagoda K. Wrobel, Michael Boutros, Jing Shen
Publikováno v: Cell Death and Differentiation
The prognosis of advanced stage neuroblastoma patients remains poor and, despite intensive therapy, the 5-year survival rate remains less than 50%. We previously identified histone deacetylase (HDAC) 8 as an indicator of poor clinical outcome and a s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e1c15279863d8f2560b093c6833de6
https://doi.org/10.1038/s41418-018-0080-0
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4
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance
Autor: Katharina Koerholz, Aubry K. Miller, Fiona R. Kolbinger, Anne Hamacher-Brady, Siavosh Mahboobi, Peter Schmezer, Heike Peterziel, Ina Oehme, Johannes Ridinger, E Koeneke, Nikolas Gunkel, Olaf Witt, Lars Hellweg
Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Drug resistance is a leading cause for treatment failure in many cancers, including neuroblastoma, the most common solid extracranial childhood malignancy. Previous studies from our lab indicate that histone deacetylase 10 (HDAC10) is important for t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f954411b09d965f66279c122bc8e03
http://europepmc.org/articles/PMC6030077
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5
HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities
Autor: Olaf Witt, Ina Oehme, E Koeneke
Publikováno v: Cells, Vol 4, Iss 2, Pp 135-168 (2015)
Cells
The exploitation of autophagy by some cancer entities to support survival and dodge death has been well-described. Though its role as a constitutive process is important in normal, healthy cells, in the milieu of malignantly transformed and highly pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e9b88cc89fb57f94743e9d3b5ef50e
http://www.mdpi.com/2073-4409/4/2/135
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