Zobrazeno 1 - 10
of 158
pro vyhledávání: '"E James Petersson"'
Autor:
Jennifer Ramirez, Ibrahim G Saleh, Evan S K Yanagawa, Marie Shimogawa, Emily Brackhahn, E James Petersson, Elizabeth Rhoades
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0309416 (2024)
Age-related neurodegenerative disorders like Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by deposits of protein aggregates, or amyloid, in various regions of the brain. Historically, aggregation of a single protein was obs
Externí odkaz:
https://doaj.org/article/5a23b84c2535422aa5848ff550330d7b
Autor:
William N Zagotta, Brandon S Sim, Anthony K Nhim, Marium M Raza, Eric GB Evans, Yarra Venkatesh, Chloe M Jones, Ryan A Mehl, E James Petersson, Sharona E Gordon
Publikováno v:
eLife, Vol 10 (2021)
With the recent explosion in high-resolution protein structures, one of the next frontiers in biology is elucidating the mechanisms by which conformational rearrangements in proteins are regulated to meet the needs of cells under changing conditions.
Externí odkaz:
https://doaj.org/article/93b61d38288c44e393a7774bb956124a
Publikováno v:
eLife, Vol 9 (2020)
NatB is one of three major N-terminal acetyltransferase (NAT) complexes (NatA-NatC), which co-translationally acetylate the N-termini of eukaryotic proteins. Its substrates account for about 21% of the human proteome, including well known proteins su
Externí odkaz:
https://doaj.org/article/9d35bf8ff2de44ac970822239928d144
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1476 (2023)
The small neuronal protein α-synuclein (αS) is found in pre-synaptic terminals and plays a role in vesicle recycling and neurotransmission. Fibrillar aggregates of αS are the hallmark of Parkinson’s disease and related neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/a9e11074ac4e42c78525b073694cd652
Autor:
Nicholas P. Marotta, Jahan Ara, Norihito Uemura, Marshall G. Lougee, Emily S. Meymand, Bin Zhang, E. James Petersson, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological features of many neurodegenerative diseases. They consist largely of aggregated forms of the protein alpha-Synuclein (α-Syn), which misfolds to give rise t
Externí odkaz:
https://doaj.org/article/bf7a534148ef4b5692dfe56fe3d96872
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The incorporation of unnatural amino acids (Uaas) has provided an avenue for novel chemistries to be explored in biological systems. However, the successful application of Uaas is often hampered by site-specific impacts on protein yield and
Externí odkaz:
https://doaj.org/article/c1284061dfd245adaed36a4cf18dc1a1
Autor:
Howard Gamper, Haixing Li, Isao Masuda, D. Miklos Robkis, Thomas Christian, Adam B. Conn, Gregor Blaha, E. James Petersson, Ruben L. Gonzalez, Ya-Ming Hou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Genome recoding with quadruplet codons requires a +1-frameshift-suppressor tRNA able to insert an amino acid at quadruplet codons of interest. Here the authors identify the mechanisms resulting in +1 frameshifting and the steps of the elongation cycl
Externí odkaz:
https://doaj.org/article/f25e7830b887458f96ecdebbbd086160
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 317 (2023)
The use of computer-aided drug design (CADD) for the identification of lead compounds in radiotracer development is steadily increasing. Traditional CADD methods, such as structure-based and ligand-based virtual screening and optimization, have been
Externí odkaz:
https://doaj.org/article/c4d10d7205194e4e9f905aa0ac62da49
Autor:
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F. Olufemi, Ronald J. Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K. Williams, Shino Magaki, Harry V. Vinters, Hilal A. Lashuel, Benjamin A. Garcia, E. James Petersson, John Q. Trojanowski, Virginia M.-Y. Lee, Chao Peng
Publikováno v:
Nature neuroscience, vol 26, iss 2
Cell-to-cell transmission and subsequent amplification of pathological proteins promote neurodegenerative disease progression. Most research on this has focused on pathological protein seeds, but how their normal counterparts, which are converted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7706c34493fd3dbe9b25fe7c59aed2e
https://doi.org/10.1038/s41593-022-01239-7
https://doi.org/10.1038/s41593-022-01239-7
Autor:
Savanna Avila-Crump, Marcus L. Hemshorn, Chloe M. Jones, Lea Mbengi, Kyle Meyer, Joshua A. Griffis, Subhashis Jana, Grace E. Petrina, Vinayak V. Pagar, P. Andrew Karplus, E. James Petersson, John J. Perona, Ryan A. Mehl, Richard B. Cooley
Publikováno v:
ACS Chemical Biology. 17:3458-3469
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a97d1458deabcda379877d18285691f0
https://doi.org/10.1021/acschembio.2c00639
https://doi.org/10.1021/acschembio.2c00639