Dynamics of central remyelination and treatment evolution in a model of Multiple Sclerosis with Optic Coherence Tomography

Autor: F. de Castro, E J de la Rosa, Carmen Gil, Ana Martínez, R. Benitez-Fernandez, Carolina Melero-Jerez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences, Vol 22, Iss 2440, p 2440 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 5

The need for remyelinating drugs is essential for healing disabling diseases such as multiple sclerosis (MS). One of the reasons for the lack of this class of therapies is the impossibility to monitor remyelination in vivo, which is of utmost importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9071947c276911c48ceec74f4e83a95a
http://hdl.handle.net/10261/250359

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

Autor: Alberto M. Hernández-Pinto, S H Latorre, E J de la Rosa, Ana Serrano-Puebla, Lucia Garcia-Ledo, Patricia Boya, Natalia Rodriguez-Muela

Retinitis pigmentosa is a group of hereditary retinal dystrophies that normally result in photoreceptor cell death and vision loss both in animal models and in affected patients. The rd10 mouse, which carries a missense mutation in the Pde6b gene, ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db8f1470a939966b918e71e14c9d070
https://europepmc.org/articles/PMC4326579/

Apoptotic cell death of proliferating neuroepithelial cells in the embryonic retina is prevented by insulin

Autor: E J de la Rosa, Belén Pimentel, F de Pablo, B Díaz

Publikováno v: European Journal of Neuroscience. 11:1624-1632

The role of programmed cell death is well established for connecting neurons. Conversely, much less is known about apoptosis affecting proliferating neuroepithelial cells. Chick retina from day 4 to day 6 of embryonic development (E), essentially pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52129e235235bc8c5a4662d4cfa75c3e
https://doi.org/10.1046/j.1460-9568.1999.00577.x

Developmentally regulated expression of the preproinsulin gene in the chicken embryo during gastrulation and neurulation

Autor: E J de la Rosa, F de Pablo, Aixa V. Morales, Beatriz Pérez-Villamil

Publikováno v: Endocrinology. 135:2342-2350

Despite the absence of a pancreas, which develops between embryonic day 3 (E3) to E4, previous studies showed that insulin receptors are widely expressed in chicken embryos from the blastoderm stage (unincubated embryo, E0) through gastrulation (E0.5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9584aa9daa122ef68a68b6f1cb1a58a
https://doi.org/10.1210/endo.135.6.7988416

Functional and structural modifications during retinal degeneration in the rd10 mouse

Autor: Francisco Germain, P. de la Villa, Laura Fernández-Sánchez, E J de la Rosa, Nicolás Cuenca, Silvia Corrochano, Gema Martínez-Navarrete, R. Barhoum

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

16 páginas, 10 figuras, 1 tabla -- PAGS nros. 698-713
Mouse models of retinal degeneration are useful tools to study therapeutic approaches for patients affected by hereditary retinal dystrophies. We have studied degeneration in the rd10 mice b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fe11a3617a5d12402289ef0c645aa4
https://hdl.handle.net/10045/16723