Zobrazeno 1 - 10
of 20
pro vyhledávání: '"E J, Wawrzynczak"'
Autor:
E J, Wawrzynczak, A J, Cumber
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 80
Cytotoxic antibody-toxin conjugates made using antibodies and ribs some-inactivating proteins (RIPs) are prepared using chemical crosslinking methods (1,2 and this vol., Chapter 31 ). Gel permeation chromatography is used as a first step to purify co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ab456bf4ef21768197fadef3eac65d82
https://pubmed.ncbi.nlm.nih.gov/22351224
https://pubmed.ncbi.nlm.nih.gov/22351224
Publikováno v:
British Journal of Cancer
The cytotoxic activity profile of an immunotoxin, SWA11-ricin A chain, recognising a cell-surface antigen associated with human small cell lung cancer (SCLC), was examined in detail using a panel of SCLC, non-SCLC and non lung tumour cell lines in ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fd0f566b8749564699d0f373934602
https://doi.org/10.1038/bjc.1992.294
https://doi.org/10.1038/bjc.1992.294
Publikováno v:
The Journal of Immunology. 149:120-126
A murine antibody FvCys fragment with a single additional cysteine residue at the C terminus of the VH domain was expressed in Escherichia coli from a modified expression plasmid containing the structural genes for the VH and VL domains derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f567fe61b4339cc58232b03968c2af8
https://doi.org/10.4049/jimmunol.149.1.120
https://doi.org/10.4049/jimmunol.149.1.120
Autor:
Uwe Zangemeister-Wittke, G. D. Parnell, Robert Waibel, A. J. Cumber, Rolf A. Stahel, M. Jones, E. J. Wawrzynczak, R. V. Henry
Publikováno v:
British Journal of Cancer
An immunotoxin (IT) comprising abrin A chain attached to the mouse monoclonal antibody SWA11, recognising a cell surface antigen highly associated with human small cell lung cancer (SCLC), was synthesised using a hindered disulphide crosslinker, N-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482876941dafcbd669637217fb70b686
http://europepmc.org/articles/PMC1977812
http://europepmc.org/articles/PMC1977812
Autor:
E. J. Wawrzynczak, A. J. S. Davies
Publikováno v:
Clinical and Experimental Immunology. 82:189-193
Antibody molecules have advantages in tumour targeting in that they can activate secondary immune effector mechanisms and can be used as carriers of cytotoxic agents and various biological response modulators. This review compares the different strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c714ea57c24b31664cea53e3be0331
https://doi.org/10.1111/j.1365-2249.1990.tb05425.x
https://doi.org/10.1111/j.1365-2249.1990.tb05425.x
Autor:
G. D. Parnell, E. J. Derbyshire, A Smith, Rolf A. Stahel, Robert Waibel, E. J. Wawrzynczak, R. V. Henry
Publikováno v:
British Journal of Cancer
The potential of mouse monoclonal antibodies for recognising different antigens associated with human small cell lung cancer (SCLC) to form active immunotoxins was assessed by an indirect in vitro screening assay. The screening agent used was a conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5de215252a56e89dcdef2d055a50a30
https://doi.org/10.1038/bjc.1990.308
https://doi.org/10.1038/bjc.1990.308
Autor:
A J, Cumber, E J, Wawrzynczak
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 80
Conjugates of antibodies with plant toxins, such as ricin and abrin, are potent cytotoxic agents that selectively eliminate target cells from mixed cell cultures in vitro, and have great promise as antitumor agents in cancer therapy (1). Ricin and ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d718e1ce686cd616ebc84ee19556ad5a
https://pubmed.ncbi.nlm.nih.gov/9664370
https://pubmed.ncbi.nlm.nih.gov/9664370
Autor:
and Annette G. Beck-Sickinger, H P Lehmann, E. J. Wawrzynczak, Robert Waibel, Gerd Folkers, Rolf A. Stahel, Erich Weber
Publikováno v:
Clinical and experimental immunology. 93(2)
SUMMARY We recently described the identity of the small cell lung cancer (SCLC) cluster-w4 antigen and the human B cell differentiation marker CD24, a glycosylphosphatidylinositol (GPI)-anchored, highly glycosylated surface molecule of only 31–35 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f68b9fb7bf550b6e4f16a9682c3767b
https://pubmed.ncbi.nlm.nih.gov/7688677
https://pubmed.ncbi.nlm.nih.gov/7688677
Autor:
E J, Wawrzynczak
Publikováno v:
Anti-cancer drug design. 7(5)
Immunotoxins are hybrid protein molecules created by the chemical or genetic fusion of an antibody and a protein toxin. Advances in the molecular engineering of monoclonal antibodies and toxins now permit the generation of a variety of immunotoxin ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca8e57474463fe2795f60dbf770399fb
https://pubmed.ncbi.nlm.nih.gov/1388633
https://pubmed.ncbi.nlm.nih.gov/1388633
Publikováno v:
Clinical and experimental immunology. 89(3)
SUMMARY A ricin A chain immunotoxin, SEN36-ricin A chain, directed against the neural cell adhesion molecule (N-CAM) had no selective cytotoxic activity against three different small cell lung cancer (SCLC) cell lines in tissue culture despite expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febdf13cafd5f55d3216107c8ca365b1
https://pubmed.ncbi.nlm.nih.gov/1325302
https://pubmed.ncbi.nlm.nih.gov/1325302