Zobrazeno 1 - 10
of 22
pro vyhledávání: '"E J, Van Zoelen"'
Autor:
M L, van de Poll, W, van Rotterdam, M M, Gadellaa, C, Stortelers, M J, van Vugt, E J, van Zoelen
Publikováno v:
The Biochemical journal. 349(Pt 1)
With the help of 16 chimaeras between human epidermal growth factor (hEGF) and human transforming growth factor alpha (hTGF alpha), a detailed analysis was performed on the epitope recognized by two polyclonal antibodies raised against hEGF, and one
Publikováno v:
Vitamins and hormones. 59
Epidermal growth factor (EGF) has been the prototype growth-stimulating peptide for many years. It has a characteristic structure with three disulfide bridges, which is essential for its activity. However, many other proteins, including both growth f
Autor:
S W, de Laat, J, Boonstra, L H, Defize, W, Kruijer, P T, van der Saag, L G, Tertoolen, E J, van Zoelen, J, den Hertog
Publikováno v:
The International journal of developmental biology. 43(7)
Signalling between cells in the developing vertebrate embryo is essential for normal embryonic development. In the mid 1970's, signal transduction research started at the Hubrecht Laboratory with special emphasis on analysis of the signalling mechani
Publikováno v:
Journal of cellular physiology. 180(2)
Activin A and osteogenic protein-1 (OP-1) exerted antagonistic effects on each other's responses on the human Tera-2 embryonal carcinoma cell line. OP-1 dose dependently inhibited activin A-induced activation of p3TP-Lux transcriptional reporter, con
Publikováno v:
International journal of cancer. 80(5)
A panel of 6 human glioma cell lines was examined for TGF-beta1 responsiveness. U-178 MG and U-251 MG AgCl1 were significantly inhibited by TGF-beta1, while U-343 MGa 31L and U-343 MGa 35L were potently stimulated to proliferate. TGF-beta1 induced en
Publikováno v:
Journal of cellular physiology. 170(2)
The effects of the phosphoinositide-mobilizing agonist bradykinin (BK) on membrane potential and intracellular calcium in monolayers of normal rat kidney (NRK) fibroblasts were investigated. BK induced a rapid transient depolarization in these cells,
Autor:
G B, Afink, M, Nistér, B H, Stassen, P H, Joosten, P J, Rademakers, E, Bongcam-Rudloff, E J, Van Zoelen, S, Mosselman
Publikováno v:
Oncogene. 10(8)
Expression of the platelet-derived growth factor alpha receptor (PDGF alpha R) is strictly regulated during mammalian development and tumorigenesis. The molecular mechanisms involved in the specific regulation of PDGF alpha R expression are unknown,
Publikováno v:
Cellular and molecular biology (Noisy-le-Grand, France). 40(5)
Normal rat kidney fibroblasts, density-arrested in the presence of epidermal growth factor (EGF), can be restimulated to proliferate in a synchronous way and acquire a transformed phenotype following treatment with additional growth factors like reti
Autor:
R H, Kramer, A E, Lenferink, I L, van Bueren-Koornneef, A, van der Meer, M L, van de Poll, E J, van Zoelen
Publikováno v:
The Journal of biological chemistry. 269(12)
Human epidermal growth factor (hEGF) and human transforming growth factor-alpha (hTGF-alpha) are structurally related growth factors that share relatively little sequence homology. They both exert their biological action by binding to the cell-surfac
Publikováno v:
Cancer research. 54(1)
Two novel platelet-derived growth factor (PDGF) alpha-receptor transcripts of 1.5 kilobases and 5.0 kilobases are expressed in the human teratocarcinoma cell line Tera-2 only while the cells are in an undifferentiated state. After retinoic acid-induc