Výsledky vyhledávání - "E J, Mroszczak"

Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals

Autor: E J, Mroszczak, D, Jung, J, Yee, L, Bynum, H, Sevelius, I, Massey

Publikováno v: Pharmacotherapy. 10(6 ( Pt 2))

In humans, ketorolac is completely bioavailable and its kinetics are linear. It is absorbed rapidly (half-life for absorption 3.8 min) after oral (fasting) and intramuscular administration; food delays but does not reduce its absorption. The drug is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b73cbcaa1051b91fbfbc0b7e3b7069b
https://pubmed.ncbi.nlm.nih.gov/2082311

Zobrazit plný text záznamu

Tiopinac absorption, distribution, excretion, and pharmacokinetics in man and animals

Autor: E J, Mroszczak, F W, Lee

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 8(6)

[14C]Tiopinac disposition was evaluated in man, monkey, rabbit, mouse, minipig, and rat. The absorption of tiopinac was rapid and essentially complete in these species. Peak plasma levels occurred in less than 1 hr to 2 hr in all species. Following i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59f2a3ac407935f6947c09d1feed6f39
https://pubmed.ncbi.nlm.nih.gov/6109609

Zobrazit plný text záznamu

Ketorolac tromethamine absorption, distribution, metabolism, excretion, and pharmacokinetics in animals and humans

Autor: E J, Mroszczak, F W, Lee, D, Combs, F H, Sarnquist, B L, Huang, A T, Wu, L G, Tokes, M L, Maddox, D K, Cho

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 15(5)

Ketorolac tromethamine (KT), a potent non-narcotic analgesic, with cyclooxygenase inhibitory activity, was administered (14C-labeled and unlabeled) intravenously (iv), orally (po), and intramuscularly (im) in solution to humans, cynomolgus monkeys, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94386eb8c486215ee2ce2ff35af0d1d1
https://pubmed.ncbi.nlm.nih.gov/2891477

Zobrazit plný text záznamu

Pharmacokinetics of ketorolac and p-hydroxyketorolac following oral and intramuscular administration of ketorolac tromethamine

Autor: D, Jung, E J, Mroszczak, A, Wu, T L, Ling, H, Sevelius, L, Bynum

Publikováno v: Pharmaceutical research. 6(1)

Ketorolac tromethamine (KT), a potent analgesic with cyclooxygenase inhibitory activity, was administered in an open, randomized, single-dose study of Latin-square design to 12 healthy male volunteers. Doses of 30 mg oral (po) and 30, 60, and 90 mg i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a2e94867d7c1b27789093521882fcdd
https://pubmed.ncbi.nlm.nih.gov/2717521

Zobrazit plný text záznamu

The metabolism and pharmacokinetics of nicardipine hydrochloride in man

Autor: O. F. Alexander, D. J. Hall, D. J. M. Graham, R. J. Dow, E. J. Mroszczak, D. Freedman

Publikováno v: British journal of clinical pharmacology. 20

Studies have been carried out to investigate the disposition of nicardipine hydrochloride following intravenous and oral administration to male volunteers. Following oral administration of a radiolabelled dose, nicardipine was shown to be rapidly and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb08afbadd97314c55db5df7e1a479d
https://pubmed.ncbi.nlm.nih.gov/4027149

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání