Zobrazeno 1 - 10
of 311
pro vyhledávání: '"E J, FREIREICH"'
Publikováno v:
Blood. 79:1802-1810
Since the translocation breakpoint t(15;17) (q22;q21) in acute promyelocytic leukemia (APL) occurs within the retinoic acid receptor- alpha (RARA) gene, the expression of many genes normally regulated by RARA may be affected by this translocation. To
Autor:
E J, Freireich
Publikováno v:
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 7(1)
Autor:
A, Ferrajoli, T, Manshouri, Z, Estrov, M J, Keating, S, O'Brien, S, Lerner, M, Beran, H M, Kantarjian, E J, Freireich, M, Albitar
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(4)
Vascular endothelial growth factor receptor-2 (VEGFR-2), also termed KDR, is a high-affinity vascular endothelial growth factor (VEGF) receptor. VEGFR-2 plays a role in de novo blood vessel formation and hematopoietic cell development. Recently, we f
Publikováno v:
Cancer. 89(7)
The objectives of this study were to describe cases of avascular necrosis of the femoral head (ANFH) observed in chronic myeloid leukemia (CML) patients who were treated with interferon-alpha and to review the literature.The authors undertook a case
Autor:
Q, Gao, M, Horwitz, D, Roulston, F, Hagos, N, Zhao, E J, Freireich, H M, Golomb, O I, Olopade
Publikováno v:
Genes, chromosomescancer. 28(2)
The molecular mechanism for the occurrence of leukemia in multiple members of a family has not been fully elucidated but data support the contribution of highly penetrant mutations in leukemia susceptibility genes. We have investigated the genetic et
Autor:
E H, Estey, F J, Giles, H, Kantarjian, S, O'Brien, J, Cortes, E J, Freireich, G, Lopez-Berestein, M, Keating
Publikováno v:
Blood. 94(7)
All-trans retinoic acid administered orally (oral ATRA) may not regularly lead to either molecular complete remissions (CRs) or prolonged hematologic CRs (HCR) unless combined with chemotherapy. Because serum tretinoin concentrations are higher, and
Publikováno v:
Cancer. 85(7)
Interleukin-2 (IL-2) has immunomodulatory effects, including stimulating the activity of cytotoxic T cells and natural killer cells, and inducing the generation of lymphokine-activated killer cells. The authors investigated whether IL-2 may improve t
Autor:
E J, Freireich
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(12 Pt 2)
Dr. Emil J Freireich is a pioneer in the rational treatment of cancer in general and leukemia in particular. This essay in his honor suggests that the cell kill concept of chemotherapy of acute myeloblastic leukemia be extended to include two additio