Zobrazeno 1 - 10
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pro vyhledávání: '"E Hille"'
Akademický článek
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Publikováno v:
ACS Medicinal Chemistry Letters. 2:2-6
Outgoing from an etomidate-based design concept, we succeeded in the development of a series of highly active and selective inhibitors of CYP11B1, the key enzyme of cortisol biosynthesis, as potential drugs for the treatment of Cushing's syndrome and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7559f4da30f8b7f24cc96910f72613
https://doi.org/10.1021/ml100071j
https://doi.org/10.1021/ml100071j
Publikováno v:
Journal of Medicinal Chemistry. 53:5749-5758
Androgens are well-known to stimulate prostate cancer (PC) growth. Thus, blockade of androgen production in testes and adrenals by CYP17 inhibition is a promising strategy for the treatment of PC. Moreover, many PC patients suffer from glucocorticoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278234fd9e8b55c5b35badd2a6734b44
https://doi.org/10.1021/jm100317b
https://doi.org/10.1021/jm100317b
Akademický článek
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Autor:
Mariano A E Pinto-Bazurco Mendieta, Thomas Lauterbach, Carsten A. Vock, Ulrike E. Hille, Rolf W. Hartmann, Qingzhong Hu, Marc Bartels
Publikováno v:
Comptes Rendus Chimie. 12:1117-1126
Four out of six CYP enzymes involved in steroid biosynthesis are very interesting targets for the development of new drugs in order to treat a variety of severe illnesses. Herein we report on a novel approach for the discovery of hit compounds using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23db91b4d20902cd63e2cf8f8a87ae7f
https://doi.org/10.1016/j.crci.2009.03.007
https://doi.org/10.1016/j.crci.2009.03.007
Publikováno v:
Zeitschrift für Orthopädie und ihre Grenzgebiete. 123:837-840
The importance of the menisci for stability of the knee joint is pointed out. Because of its mechanical importance in the knee a more conservative behaviour for treatment is recommended. Even the degenerated meniscus can play his role sufficiently. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2968608a22b3e8a3ebbc427d7f3a1b78
https://doi.org/10.1055/s-2008-1044764
https://doi.org/10.1055/s-2008-1044764
Autor:
K. P. Schulitz, E. Hille
Publikováno v:
Zeitschrift für Orthopädie und ihre Grenzgebiete. 123:23-26
Using strain gauges we investigated proximal-distal and lateral-medial strain of the dorsum patellae before and after cutting of the lateral retinaculum and the plica mediopatellaris under flexion. Lateral-medial strain was abolished by the lateral r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3688300ef5acb789666a2af03c3fba0c
https://doi.org/10.1055/s-2008-1039715
https://doi.org/10.1055/s-2008-1039715
Publikováno v:
Zeitschrift für Orthopädie und ihre Grenzgebiete. 127:56-64
31 healthy persons had to run on a treadmill under defined conditions at a constant speed of 8 km/h. Pressure in the anterior flexor-muscles compartment was measured regulary in time before, during and after running; the size of the compartment was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b8a062681d73ead9aa25f7ac5329182
https://doi.org/10.1055/s-2008-1040089
https://doi.org/10.1055/s-2008-1040089
Publikováno v:
Zeitschrift für Orthopädie und ihre Grenzgebiete. 134:171-176
The question is, if a possible concentration of stress in the segment adjacent to the fusion level might result in disc degeneration. Two series of patients have been evaluated: One group of 70 patients underwent a posterolateral fusion without instr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b376288210f1ea9fa42de0b95ce03d73
https://doi.org/10.1055/s-2008-1039791
https://doi.org/10.1055/s-2008-1039791
Autor:
K.-P. Schulitz, E. Hille
Publikováno v:
Zeitschrift für Orthopädie und ihre Grenzgebiete. 122:40-47
At 13 post-mortem-knees we investigated the patello-femoral contact area in different degrees of function, referring to the localization of chondromalacia. We found that the localization of chondromalacia didn't accord to the contact area in 50% of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::186fb06d3a811f823dc9486d0c938365
https://doi.org/10.1055/s-2008-1044582
https://doi.org/10.1055/s-2008-1044582