Zobrazeno 1 - 10
of 36
pro vyhledávání: '"E Hesper, Rego"'
Autor:
Wei L. Ng, E. Hesper Rego
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT Antibiotic resistance in Mycobacterium tuberculosis exclusively originates from chromosomal mutations, either during normal DNA replication or under stress, when the expression of error-prone DNA polymerases increases to repair damaged DNA.
Externí odkaz:
https://doaj.org/article/d808c4e477ee412eaca1e0cdf6d11376
Autor:
Kuldeepkumar R Gupta, Celena M Gwin, Kathryn C Rahlwes, Kyle J Biegas, Chunyan Wang, Jin Ho Park, Jun Liu, Benjamin M Swarts, Yasu S Morita, E Hesper Rego
Publikováno v:
eLife, Vol 11 (2022)
Mycobacteria, including the human pathogen Mycobacterium tuberculosis, grow by inserting new cell wall material at their poles. This process and that of division are asymmetric, producing a phenotypically heterogeneous population of cells that respon
Externí odkaz:
https://doaj.org/article/d2ce6e407dec4b2a9f3a6d527a6e74ef
Publikováno v:
Mol Microbiol
The mycobacterial cell wall is profoundly regulated in response to environmental stresses, and this regulation contributes to antibiotic tolerance. The reversible phosphorylation of different cell wall regulatory proteins is a major mechanism of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c657969fef7a6d40d41d7724918f0b
https://doi.org/10.1111/mmi.14951
https://doi.org/10.1111/mmi.14951
Autor:
Catherine Baranowski, Michael A Welsh, Lok-To Sham, Haig A Eskandarian, Hoong Chuin Lim, Karen J Kieser, Jeffrey C Wagner, John D McKinney, Georg E Fantner, Thomas R Ioerger, Suzanne Walker, Thomas G Bernhardt, Eric J Rubin, E Hesper Rego
Publikováno v:
eLife, Vol 7 (2018)
In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unus
Externí odkaz:
https://doaj.org/article/6695fdf7fa9f4cceb2741307353a71cf
Autor:
Celena M Gwin, Kuldeepkumar R Gupta, Kathryn C Rahlwes, Kyle J Biegas, Chunyan Wang, Jin Ho Park, Jun Liu, Benjamin M Swarts, Yasu S Morita, E Hesper Rego
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d974b6ee210e0815d25e055efa40d58d
https://doi.org/10.7554/elife.80395.sa2
https://doi.org/10.7554/elife.80395.sa2
Autor:
Emily S. Melzer, Takehiro Kado, Alam García-Heredia, Kuldeepkumar Ramnaresh Gupta, Xavier Meniche, Yasu S. Morita, Christopher M. Sassetti, E. Hesper Rego, M. Sloan Siegrist
Publikováno v:
J Bacteriol
The paper “Cell wall damage reveals spatial flexibility in peptidoglycan synthesis and a nonredundant role for RodA in mycobacteria” by Melzer et al. (E. S. Melzer, T. Kado, A. Garcia-Heredia, K. R. Gupta, et al., J Bacteriol 204:e00540-21, 2022,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae0085340c9de2eaac967e216e95b9c
https://pubmed.ncbi.nlm.nih.gov/35543536
https://pubmed.ncbi.nlm.nih.gov/35543536
Autor:
Xavier Meniche, Christopher M. Sassetti, Kuldeepkumar Ramnaresh Gupta, Emily S. Melzer, E. Hesper Rego, Alam García-Heredia, Yasu S. Morita, Takehiro Kado, M. Sloan Siegrist
Cell wall peptidoglycan is a heteropolymeric mesh that protects the bacteria from internal turgor and external insults. In many rod-shaped bacteria, peptidoglycan synthesis for normal growth is achieved by two distinct pathways: the Rod complex, comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c78b8ea40035d7988452a96563ff7ff3
https://doi.org/10.1101/2021.10.26.465981
https://doi.org/10.1101/2021.10.26.465981
Autor:
Karen J Kieser, Cara C Boutte, Jemila C Kester, Christina E Baer, Amy K Barczak, Xavier Meniche, Michael C Chao, E Hesper Rego, Christopher M Sassetti, Sarah M Fortune, Eric J Rubin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1005010 (2015)
Cell growth and division are required for the progression of bacterial infections. Most rod-shaped bacteria grow by inserting new cell wall along their mid-section. However, mycobacteria, including the human pathogen Mycobacterium tuberculosis, produ
Externí odkaz:
https://doaj.org/article/765fe55a1c6d4311bb94f15f6f51c4b4
Autor:
Shu-Jung Chang, Weiwei Wang, Jorge E. Galán, E. Hesper Rego, TuKiet T. Lam, Maikel Boot, Hui Sun, Meixin Chen, Lin Shao, Maria Lara-Tejero
Publikováno v:
Science
The guanosine triphosphatase (GTPase) Rab32 coordinates a cell-intrinsic host defense mechanism that restricts the replication of intravacuolar pathogens such as Salmonella. Here, we show that this mechanism requires aconitate decarboxylase 1 (IRG1),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7003682192325e3bfa563ed6c65ad5
https://europepmc.org/articles/PMC8020367/
https://europepmc.org/articles/PMC8020367/