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Akademický článek
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Publikováno v:
Journal of Neuroscience Research. 45:714-722
LER rats are resistant to the active induction of experimental allergic encephalomyelitis (EAE). The mechanism of their resistance to EAE has yet to be defined, although LER rats are susceptible to adoptively transferred EAE. Genetic analysis of LER
Autor:
X M Zhang, E Heber-Katz
Publikováno v:
The Journal of Immunology. 148:746-752
In the Lewis rat, the encephalitogenic determinant of myelin basic protein (MBP), residues 68 to 88, induces an alpha beta + T cell population whose TCR beta-chains are exclusively derived from the V beta 8 TCR gene family. As presented here, sequenc
Publikováno v:
The Journal of Immunology. 147:1208-1213
Recently there has been a number of reports suggesting that CD4-CD8- T cells participate in the processes of inflammatory reaction. In an attempt to delineate the distinctive functions of double negative (DN) T lymphocytes in an autoimmune-induced di
Publikováno v:
The Journal of Immunology. 146:75-80
Experimental autoimmune uveoretinitis (EAU) is a predominantly T cell-mediated autoimmune disease induced in susceptible animals by active immunization with human or bovine retinal S-Ag or by passive transfer of activated S-Ag or peptide-specific CD4
Akademický článek
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Publikováno v:
Current topics in microbiology and immunology. 280
The ability to regenerate is thought to be a lost phenotype in mammals, though there are certainly sporadic examples of mammalian regeneration. Our laboratory has identified a strain of mouse, the MRL mouse, which has a unique capacity to heal comple
Autor:
L, Clark, L, Otvos, P L, Stein, X M, Zhang, A F, Skorupa, G E, Lesh, F A, McMorris, E, Heber-Katz
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(7)
The Golli-MBP transcription unit contains three Golli-specific exons as well as the seven exons of the classical myelin basic protein (MBP) gene and encodes alternatively spliced proteins that share amino acid sequence with MBP. Unlike MBP, which is
Publikováno v:
Investigative ophthalmologyvisual science. 39(13)
To determine the role of SPARC (secreted protein, acidic, and rich in cysteine) in cataractogenesis by examining mice deficient in a matricellular protein SPARC.Mice were rendered SPARC-deficient by a targeted disruption of the gene. Slit-lamp micros