Výsledky vyhledávání - "E H Birkenmeier"

Spx1, a novel X-linked homeobox gene expressed during spermatogenesis

Autor: M Weinstein, M T Valerius, S. Steven Potter, G Q Zhao, E H Birkenmeier, L B Rowe, William W. Branford

Publikováno v: Mechanisms of Development. 65(1-2):87-98

Spx1, a novel mouse homeobox gene, encodes a homeodomain characteristic of the paired-like class of homeobox genes and has been mapped to the distal end of the X chromosome. Northern blot hybridization of adult tissues detected high levels of a singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cffd34f80971e7528eb68aefe7a9935

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The human sucrase-isomaltase gene directs complex patterns of gene expression in transgenic mice

Autor: Peter G. Traber, E. H. Birkenmeier, Gary D. Wu, A. J. Markowitz

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 265:G526-G539

Sucrase-isomaltase (SI) is an enterocyte-specific gene that is expressed in complex developmental and spatial patterns. In this study, we examine the ability of regulatory elements within the human SI (hSI) gene to direct appropriate cell lineage and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5578d5045a3e92573c9a356b82d8de3a
https://doi.org/10.1152/ajpgi.1993.265.3.g526

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Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage- specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium

Autor: Steven M. Cohn, Kevin A. Roth, E H Birkenmeier, T. C. Simon, Jeffrey I. Gordon

Publikováno v: The Journal of Cell Biology

The mouse intestinal epithelium is able to establish and maintain complex lineage-specific, spatial, and temporal patterns of gene expression despite its rapid and continuous renewal. A multipotent stem cell located near the base of each intestinal c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97a2b3ae338cebe770a9a643712cf96
http://europepmc.org/articles/PMC2289640

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Increased life span and correction of metabolic defects in murine mucopolysaccharidosis type VII after syngeneic bone marrow transplantation

Autor: E H, Birkenmeier, J E, Barker, C A, Vogler, J W, Kyle, W S, Sly, B, Gwynn, B, Levy, C, Pegors

Publikováno v: Blood. 78:3081-3092

The gusmps/gusmps mouse has no beta-glucuronidase activity and develops murine mucopolysaccharidosis type VII (MPS VII). The clinical and pathologic abnormalities are similar to those found in humans with severe MPS VII. Mutant mice are dysmorphic, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a705b6d2fe134ca1203f1c1d8c85cf
https://doi.org/10.1182/blood.v78.11.3081.bloodjournal78113081

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Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation

Autor: Kevin A. Roth, Roderick T. Bronson, C A Langner, Jeffrey I. Gordon, E H Birkenmeier

Publikováno v: Journal of Biological Chemistry. 266:11955-11964

In a previous report (Langner, C. A., Birkenmeier, E. H., Ben-Zeev, O., Schotz, M. C., Sweet, H. O., Davisson, M. T., and Gordon, J. I. (1989) J. Biol. Chem. 264, 7994-8003), we characterized the early developmental phenotype of mice that were homozy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::250cf99d56987240cc7c0f17631d0e05
https://doi.org/10.1016/s0021-9258(18)99050-2

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Expression of liver fatty acid-binding protein/human growth hormone fusion genes within the enterocyte and enteroendocrine cell populations of fetal transgenic mice

Autor: Deborah C. Rubin, E H Birkenmeier, Kevin A. Roth, Jeffrey I. Gordon

Publikováno v: Journal of Biological Chemistry. 266:5949-5954

The intestinal epithelium establishes and maintains a precise spatial organization despite its continuous and rapid renewal. We have used transgenic mice containing liver fatty acid-binding protein/human growth hormone (L-FABP/hGH) fusion genes to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48045d859cb6d7c9873be2c1829adeed
https://doi.org/10.1016/s0021-9258(19)67690-8

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Temporal and spatial patterns of transgene expression in aging adult mice provide insights about the origins, organization, and differentiation of the intestinal epithelium

Autor: Steven M. Cohn, Jeffrey I. Gordon, E H Birkenmeier, Kevin A. Roth

Publikováno v: Proceedings of the National Academy of Sciences. 88:1034-1038

We have used liver fatty acid-binding protein/human growth hormone (L-FABP/hGH) fusion genes to explore the temporal and spatial differentiation of intestinal epithelial cells in 1- to 12-month-old transgenic mice. The intact, endogenous L-FABP gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1a8629e49cd38d1de69c251c2638da
https://doi.org/10.1073/pnas.88.3.1034

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Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora

Autor: S L, Brandwein, R P, McCabe, Y, Cong, K B, Waites, B U, Ridwan, P A, Dean, T, Ohkusa, E H, Birkenmeier, J P, Sundberg, C O, Elson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(1)

The idiopathic inflammatory bowel diseases, ulcerative colitis and Crohn's disease, are chronic disorders that appear to arise from an aberrant interaction of environmental, genetic, and immunologic factors. The aim of this study was to examine the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a26efdab004f092d72256cc7cfc3cd6b
https://pubmed.ncbi.nlm.nih.gov/9200437

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Enzyme replacement with recombinant beta-glucuronidase in murine mucopolysaccharidosis type VII: impact of therapy during the first six weeks of life on subsequent lysosomal storage, growth, and survival

Autor: Nancy Galvin, Beth Levy, Carole Vogler, William S. Sly, E H Birkenmeier, Mark S Sands

Publikováno v: Pediatric research. 39(6)

Treatment of mucopolysaccharidosis type VII (MPS VII) mice with recombinant mouse β-glucuronidase injections has been shown to deliver enzyme to most tissues and to reduce lysosomal storage during the first 6 wk of life. Here we determine the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9ecf9bfea49403e189f6623a34f08a
https://pubmed.ncbi.nlm.nih.gov/8725268

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Pathology of the ear in murine mucopolysaccharidosis type VII. Morphologic correlates of hearing loss

Autor: C L, Berry, C, Vogler, N J, Galvin, E H, Birkenmeier, W S, Sly

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 71(3)

Patients with mucopolysaccharidosis commonly have hearing impairment but the morphologic alterations in the ear caused by these lysosomal storage diseases are incompletely defined.We studied a murine model of mucopolysaccharidosis VII with clinical f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b78b171dddb09ae2e4e5a524142a3c64
https://pubmed.ncbi.nlm.nih.gov/7933993

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