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Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

Autor: Johan Kolmert, Cristina Gómez, David Balgoma, Marcus Sjödin, Johan Bood, Jon R. Konradsen, Magnus Ericsson, John-Olof Thörngren, Anna James, Maria Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Ioannis Pandis, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E. Shaw, Richard G. Knowles, Cécile T. J. Holweg, Åsa M. Wheelock, Barbro Dahlén, Björn Nordlund, Kjell Alving, Gunilla Hedlin, Kian Fan Chung, Ian M. Adcock, Peter J. Sterk, Ratko Djukanovic, Sven-Erik Dahlén, Craig E. Wheelock, H. Ahmed, C. Auffray, A. T. Bansal, E. H. Bel, J. Bigler, B. Billing, F. Baribaud, H. Bisgaard, M. J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, A. Chaiboonchoe, C. H. Compton, J. Corfield, D. Cunoosamy, A. D’Amico, B. De Meulder, V. J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L. J. Fleming, E. Formaggio, U. Frey, M. Gahlemann, V. Goss, Y. Guo, S. Hashimoto, J. Haughney, P. W. Hekking, T. Higenbottam, J. M. Hohlfeld, A. J. Knox, N. Lazarinis, D. Lefaudeux, M. J. Loza, R. Lutter, A. Manta, S. Masefield, J. G. Matthews, A. Mazein, A. Meiser, R. J. M. Middelveld, M. Miralpeix, N. Mores, C. S. Murray, J. Musial, D. Myles, L. Pahus, S. Pavlidis, A. Postle, P. Powel, G. Praticò, M. PuigValls, N. Rao, A. Roberts, G. Roberts, A. Rowe, T. Sandström, J. P. R. Schofield, W. Seibold, A. Selby, R. Sigmund, F. Singer, P. J. Skipp, M. Smicker, K. Sun, B. Thornton, M. Uddin, W. M. van Aalderen, M. van Geest, J. Vestbo, N. H. Vissing, A. H. Wagener, S. S. Wagers, Z. Weiszhart, S. J. Wilson, J. Östling

Publikováno v: U-BIOPRED Study Group 2020, ' Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study. ', American Journal of Respiratory and Critical Care Medicine, vol. 203, no. 1, pp. 37-53 . https://doi.org/10.1164/rccm.201909-1869OC
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2021, 203 (1), pp.37-53. ⟨10.1164/rccm.201909-1869OC⟩

Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e52ab64017bba43414900205d8dbd0
https://doi.org/10.1164/rccm.201909-1869OC

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Predictors of benefit from high-altitude climate therapy in adults with severe asthma

Autor: S, Hashimoto, L H, Rijssenbeek-Nouwens, K B, Fieten, E J, Weersink, E H, Bel

Publikováno v: The Netherlands journal of medicine. 76(5)

High-altitude climate therapy has been shown to benefit patients with severe asthma but it is not known which patients benefit most from this treatment. In the current study we aimed to identify clinical, functional and inflammatory predictors of fav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfc6abb4a21e4b77bef61c400a3d0e01
https://pubmed.ncbi.nlm.nih.gov/30019675

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A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

Publikováno v: American journal of respiratory and critical care medicine, 179(7), 549-558. American Thoracic Society

Rationale The treatment effect of golimumab, a human monoclonal antibody against tumor necrosis factor (TNF)-alpha, in severe persistent asthma is unknown. Objectives To assess the safety and efficacy of golimumab in a large population of patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c0f2c63111182d318d3bd90337039f
https://doi.org/10.1164/rccm.200809-1512oc

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External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease

Autor: N, Fens, A C, Roldaan, M P, van der Schee, R J, Boksem, A H, Zwinderman, E H, Bel, P J, Sterk

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 41(10)

Fixed airflow limitation can be found both in asthma and chronic obstructive pulmonary disease (COPD), posing a day-to-day diagnostic challenge.We aimed to determine the external validity of metabolomic analysis of exhaled air by electronic nose for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::931dabc3bf34456168e493ea01a4e0ac
https://pubmed.ncbi.nlm.nih.gov/21732998

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High-altitude treatment: a therapeutic option for patients with severe, refractory asthma?

Autor: L H, Rijssenbeek-Nouwens, E H, Bel

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 41(6)

High-altitude treatment has been applied for more than a century in the treatment of pulmonary diseases including asthma. Many uncontrolled and controlled studies have shown its beneficial effects in children and adolescents with house dust mite alle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f22ce1e1b05747da03fd233873ef671c
https://pubmed.ncbi.nlm.nih.gov/21518039

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Quantification of theophylline-induced eosinopenia and hypokalaemia in healthy volunteers

Autor: R. E. Jonkers, E. H. Bel, M. C. P. Braat, C. J. Van Boxtel

Publikováno v: Clinical pharmacokinetics. 22(3):231-237

The relationship between theophylline pharmacokinetics and its eosinopenic and hypokalaemic effects were studied in 6 healthy volunteers after an oral dose of theophylline 250 mg. The mean peak theophylline concentration (Cmax) of 8.33 +/- 2.16 mg/L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b69eec48c011f50761dc6b829c30760
https://doi.org/10.2165/00003088-199222030-00005

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