Low nailfold capillary density in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: biomarker of clinical outcome?

Autor: A. J. Smits, K. Isebia, C. Combee-Duffy, S. van der Wal, E. J. Nossent, A. Boonstra, A. Vonk-Noordegraaf, H. J. Bogaard, E. H. Serné

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Nailfold capillary density is lower in patients with pulmonary arterial hypertension (PAH). It is unclear whether this observation signifies a unique systemic manifestation of PAH, or reflects microcirculatory dysfunction secondary to pulmon

Externí odkaz: https://doaj.org/article/1f2f4671e8114f21b07a8e2c2eae77b0

Pre-awakening diastolic hypotension in treated hypertensive patients: prevalence and predictors

Autor: K H Zheng, Yvo M. Smulders, A.J. Kooter, E H Serné

Publikováno v: Zheng, K H, Serne, E H, Kooter, A J & Smulders, Y M 2016, ' Pre-awakening diastolic hypotension in treated hypertensive patients: prevalence and predictors ', Journal of Human Hypertension, vol. 30, no. 5, pp. 322-327 . https://doi.org/10.1038/jhh.2015.80
Journal of Human Hypertension, 30(5), 322-327. Nature Publishing Group

In the pre-awakening hours, diastolic blood pressure (DBP) is normally at its lowest, and diastolic hypotension is a risk factor for cardiac ischemia. We investigated pre-awakening DBP values and its predictors in treated hypertensive patients who un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5ef15e3e5f174f3703a0dc9026d248
https://research.vumc.nl/en/publications/57325586-82a0-4844-aa96-6d9b1233bc36

Insulin's microvascular vasodilatory effects are inversely related to peripheral vascular resistance in overweight, but insulin-sensitive subjects

Autor: J M, Hornstra, E H, Serné, E C, Eringa, M C, Wijnker, M P, de Boer, J S, Yudkin, Y M, Smulders

Publikováno v: Obesity (Silver Spring, Md.). 21(12)

The mechanisms underlying obesity-related hypertension are incompletely understood. Microvascular dysfunction might play a role by increasing peripheral vascular resistance (PVR). Metabolic and microvascular effects of insulin are impaired in obesity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7f9de3b58cccc212513090d8bceb84a
https://pubmed.ncbi.nlm.nih.gov/23512652

[Microvascular dysfunction as an explanation for the metabolic syndrome]

Autor: E H, Serné, R T, de Jongh, R G, Ijzerman, C D A, Stehouwer

Publikováno v: Nederlands tijdschrift voor geneeskunde. 149(16)

The metabolic syndrome is a cluster of mutually related risk factors that confers an increased risk for both type 2 diabetes mellitus and cardiovascular disease. Although the metabolic syndrome seems to have multiple aetiological factors, microvascul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1e2ae5acd433c41cc63ef5c3d5b9b36
https://pubmed.ncbi.nlm.nih.gov/15868988

Insulin-mediated increases in renal plasma flow are impaired in insulin-resistant normal subjects

Autor: J C, Ter Maaten, S J, Bakker, E H, Serné, H J, Moshage, A J, Donker, R O, Gans

Publikováno v: European journal of clinical investigation. 30(12)

Impaired vasodilatation in skeletal muscle is a possible mechanism linking insulin resistance to blood pressure regulation. Increased renal vascular resistance has been demonstrated in the offspring of essential hypertensives. We assessed whether ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c524b311fa7a3b5c599828b5edae375
https://pubmed.ncbi.nlm.nih.gov/11122324