15 alpha-hydroxylation of a bile acid analogue, sodium 3 alpha,7 alpha-dihydroxy-25,26-bishomo-5 beta-cholane-26-sulfonate in the hamster.

Autor: T Mikami, A Ohshima, E H Mosbach, B I Cohen, N Ayyad, M Yoshii, K Ohtani, K Kihira, C D Schteingart, T Hoshita

Publikováno v: Journal of Lipid Research, Vol 37, Iss 6, Pp 1189-1197 (1996)

The metabolism of 3 alpha,7 alpha-dihydroxy-25,26-bishomo-5 beta-cholane-26-sulfonate (bishomoCDC-sul), the sulfonate analogue of bishomochenodeoxycholic acid, and its effect on biliary bile acid composition were studied during chronic administration

Externí odkaz: https://doaj.org/article/f8640555aff743319ab9cf2a78d42413

Engineering Regioselectivity of P450 BM3 Enables the Biosynthesis of Murideoxycholic Acid by 6β-Hydroxylation of Lithocholic Acid.

Autor: Deng F; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China., Zhou Z; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China., Du Z; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China., Mohany M; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Wu Q; NMPA Key Laboratory for Quality Control of Blood Products, Guangdong Institute For Drug Control, Guangzhou, P. R. China., Liang W; NMPA Key Laboratory for Quality Control of Blood Products, Guangdong Institute For Drug Control, Guangzhou, P. R. China., Zhang L; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China., Li S; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.

Publikováno v: Biotechnology journal [Biotechnol J] 2024 Nov; Vol. 19 (11), pp. e202400518.

Synthesis of 5β-cholestane-3α, 7α, 12α, 25-tetrol and 5β-cholestane-3α, 7α, 12α, 24ξ, 25-pentol

Autor: B Dayal, S Shefer, G S Tint, G Salen, E H Mosbach

Publikováno v: Journal of Lipid Research, Vol 17, Iss 1, Pp 74-77 (1976)

This paper describes syntheses of 5β-cholestane-3α, 7α, 12α, 25-tetrol and 5β-cholestane-3α, 7α, 12α, 24ξ, 25-pentol which give higher yields than previously published methods. In addition, 5β-cholestane-3α, 7α, 12α, 24ξ, 25-pentol was

Externí odkaz: https://doaj.org/article/15eee089cb224b7882f7afb747f2d82f

Regulation of bile acid 7-dehydroxylase activity by NAD+ and NADH in cell extracts of Eubacterium species V.P.I. 12708

Autor: B A White, D A Paone, A F Cacciapuoti, R J Fricke, E H Mosbach, P B Hylemon

Publikováno v: Journal of Lipid Research, Vol 24, Iss 1, Pp 20-27 (1983)

The 7 alpha-dehydroxylation of primary bile acids by Eubacterium sp. V.P.I. 12708 required a cell extract prepared from a cholic acid-induced culture and NAD+. NADH (0.5 mM) inhibited bile acid 7-dehydroxylase activity more than 50% when added to rea

Externí odkaz: https://doaj.org/article/aa256af30db34266bc2a0def4c8dee26

Absolute configuration of pentahydroxy bile alcohols excreted by patients with cerebrotendinous xanthomatosis: a circular dichroism study

Autor: B Dayal, G Salen, G S Tint, V Toome, S Shefer, E H Mosbach

Publikováno v: Journal of Lipid Research, Vol 19, Iss 2, Pp 187-190 (1978)

The absolute configurations of the C27 pentahydroxy bile alcohols present in bile and feces of two patients with cerebrotendinous xanthomatosis (CTX) were determined by circular dichroism (CD) spectroscopy. The CD spectra of 5β-cholestane-3α,7α,12

Externí odkaz: https://doaj.org/article/ab784625ebc944bdb9a48186ed6aef0a