Zobrazeno 1 - 10
of 16
pro vyhledávání: '"E H, Bresnick"'
Publikováno v:
Current topics in developmental biology. 118
Complex developmental programs require orchestration of intrinsic and extrinsic signals to control cell proliferation, differentiation, and survival. Master regulatory transcription factors are vital components of the machinery that transduce these s
The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms
Publikováno v:
Curr Top Dev Biol
Transcriptional regulators mediate the genesis and function of the hematopoietic system by binding complex ensembles of cis-regulatory elements to establish genetic networks. While thousands to millions of any given cis-element reside in a genome, ho
Autor:
E H Bresnick, Gary Felsenfeld
Publikováno v:
Journal of Biological Chemistry. 269:21110-21116
The basic helix-loop-helix transcription factor USF43 binds to E box motifs on certain promoters and enhancers, as well as the beta-globin locus control region. We have used gel filtration chromatography, velocity centrifugation, and chemical cross-l
Publikováno v:
Journal of cellular biochemistry. Supplement.
Intercellular communication that controls the developmental fate of multipotent cells is commonly mediated by the Notch family of transmembrane receptors. Specific transmembrane ligands activate Notch receptors on neighboring cells inducing the prote
Publikováno v:
Blood. 96(1)
The human beta-globin locus control region (LCR) confers high-level, tissue-specific expression to the beta-globin genes. Tandem Maf recognition elements (MAREs) within the hypersensitive site 2 (HS2) subregion of the LCR are important for the strong
Autor:
K A, Gould, E H, Bresnick
Publikováno v:
Gene expression. 7(2)
TAL1 is a helix-loop-helix transcription factor that is essential for hematopoiesis. In vitro DNA binding site selection experiments have previously identified the preferred binding site for TAL1 heterodimers as AACAGATGGT. TAL1 homodimers do not bin
Autor:
Debra A. Tonetti, M Sun, Kandis Backus, He Zhu, G. D'Souza, Ingrid Espinoza, Lucio Miele, John S. Coon, Clodia Osipo, M Caskey, Paola Rizzo, P R Strack, Antonio Pannuti, J Wu, X Zhu, Chindo Hicks, Mitchell F. Denning, E H Bresnick, Jieun Yun
Publikováno v:
Oncogenesis
The Notch pathway is functionally important in breast cancer. Notch-1 has been reported to maintain an estrogen-independent phenotype in estrogen receptor α (ERα)+ breast cancer cells. Notch-4 expression correlates with Ki67. Notch-4 also plays a k
Autor:
E H, Bresnick, G, Felsenfeld
Publikováno v:
The Journal of biological chemistry. 269(33)
The basic helix-loop-helix transcription factor USF43 binds to E box motifs on certain promoters and enhancers, as well as the beta-globin locus control region. We have used gel filtration chromatography, velocity centrifugation, and chemical cross-l
Autor:
E H, Bresnick, G, Felsenfeld
Publikováno v:
The Journal of biological chemistry. 268(25)
The human locus control region (LCR) consists of four DNase I hypersensitive sites upstream of the epsilon-globin gene and is intimately involved in globin gene transcription. We have used DNase I footprinting with K562 erythroleukemia cell extracts
Autor:
W B, Pratt, E R, Sanchez, E H, Bresnick, S, Meshinchi, L C, Scherrer, F C, Dalman, M J, Welsh
Publikováno v:
Cancer research. 49
Reports from several laboratories support a model for glucocorticoid receptor (GR) transformation in cytosol in which a heteromeric 9S complex of GR and the Mr 90,000 heat shock protein undergo a temperature-dependent and hormone-promoted dissociatio