Zobrazeno 1 - 10
of 41
pro vyhledávání: '"E H, Allan"'
Publikováno v:
Mitochondrion. 17:34-41
The nucleotide change A to G at position m.3243 in the mitochondrial tRNA leucine (UUR) gene (MT-TL1) is the most common point mutation reported in association with the Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like episodes (MELAS)
Autor:
Christina Vrahnas, Huynh Nguyen, Farzin M. Takyar, Liliana Tatarczuch, Stephen Tonna, Narelle E. McGregor, T. John Martin, Blessing Crimeen-Irwin, Ingrid J Poulton, Eleanor J. Mackie, Mark R. Forwood, Holly J. Brennan, Patricia W. M. Ho, E H Allan, Natalie A. Sims
Publikováno v:
The FASEB Journal. 28:4482-4496
Cells that form bone (osteoblasts) express both ephrinB2 and EphB4, and previous work has shown that pharmacological inhibition of the ephrinB2/EphB4 interaction impairs osteoblast differentiation in vitro and in vivo. The purpose of this study was t
Autor:
Julie M. Quach, T. John Martin, Patricia W. M. Ho, Emma C. Walker, Ingrid J Poulton, Narelle E. McGregor, Natalie A. Sims, E H Allan
Publikováno v:
Journal of Bone and Mineral Research. 27:902-912
Parathyroid hormone (PTH) is the only approved anabolic agent for osteoporosis treatment. It acts via osteoblasts to stimulate both osteoclast formation and bone formation, with the balance between these two activities determined by the mode of admin
Autor:
S. Pompolo, Matthew T. Gillespie, Natalie A. Sims, E H Allan, Ingrid J Poulton, Emma C. Walker, T. John Martin, Narelle E. McGregor, Julian M.W. Quinn
Publikováno v:
Journal of Bone and Mineral Research. 23:2025-2032
Cardiotrophin (CT-1) signals through gp130 and the LIF receptor (LIFR) and plays a major role in cardiac, neurological, and liver biology. We report here that CT-1 is also expressed within bone in osteoclasts and that CT-1 is capable of increasing os
Autor:
Tao Wei, J.M.W. Quinn, Jonathan H. Gooi, S. Pompolo, Natalie A. Sims, Matthew T. Gillespie, K D Hausler, Blessing Crimeen-Irwin, Jude E. Onyia, E H Allan, T. John Martin
Publikováno v:
Journal of Bone and Mineral Research. 23:1170-1181
With the aim of identifying new pathways and genes regulated by PTH(1-34) and PTH-related protein 1-141 [PTHrP(1-141)] in osteoblasts, this study was carried out using a mouse marrow stromal cell line, Kusa 4b10, that acquires features of the osteobl
Autor:
E H Allan, Thomas J. Martin
Publikováno v:
Fibrinolysis. 10:285-293
Summary The effect of thrombin on components of the plasminogen activator (PA)/plasmin pathway in osteoblast-like cells has been investigated. Thrombin was found to increase PA inhibitor-1 (PAI-1) mRNA and protein in a time- and dose-dependent manner
Autor:
Patricia W. M. Ho, Hong Zhou, Matthew T. Gulespie, Jane M. Moseley, E H Allan, Naoto Suda, T. John Martin, Kathy Traianedes, Daphne K. Hards
Publikováno v:
Journal of Cellular Physiology. 166:94-104
The expression of parathyroid hormone-related protein (PTHrP) was studied in a range of cell cultures representative of the osteoblast lineage and in rat calvarial sections. Primary newborn rat calvarial cells, a rat preosteoblastic cell line (UMR 20
Autor:
Thomas J. Martin, E H Allan
Publikováno v:
Journal of Cellular Physiology. 165:521-529
The bone resorbing agent, prostaglandin E2 (PGE2), was found to alter several components of the plasminogen activator (PA)/plasmin pathway in primary cultures of rat neonatal osteoblast-like cells. The mRNA and activities of both urokinase-type PA (u
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1201:223-228
In rat calvarial osteoblast-like cells and in clonal osteogenic sarcoma cells (UMR 106-01), 1,25-dihydroxyvitamin D-3 (1,25(OH)2D3) enhanced plasminogen activator (PA) activity and decreased PA inhibitor-1 (PAI-1) production over the same concentrati
Autor:
Julie M. Quach, Natalie A. Sims, Atsushi Yokoyama, T. John Martin, Emma C. Walker, Matthew T. Gillespie, Shigeaki Kato, Melissa Solano, E H Allan
Publikováno v:
The Journal of biological chemistry. 286(6)
Osteoblasts and adipocytes are derived from common mesenchymal progenitor cells. The bone loss of osteoporosis is associated with altered progenitor differentiation from an osteoblastic to an adipocytic lineage. cDNA microarrays and quantitative real