Zobrazeno 1 - 10
of 510
pro vyhledávání: '"E Guerin"'
Autor:
Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor, lipomannan (LM), which are trafficked from the bacterium to t
Externí odkaz:
https://doaj.org/article/6d93ff76e3f4412dafd8078e53d92041
Autor:
Diego E. Sastre, Nazneen Sultana, Marcos V. A. S. Navarro, Maros Huliciak, Jonathan Du, Javier O. Cifuente, Maria Flowers, Xu Liu, Pete Lollar, Beatriz Trastoy, Marcelo E. Guerin, Eric J. Sundberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Bacteroidales (syn. Bacteroidetes) are prominent members of the human gastrointestinal ecosystem mainly due to their efficient glycan-degrading machinery, organized into gene clusters known as polysaccharide utilization loci (PULs). A single
Externí odkaz:
https://doaj.org/article/ebe073fb96474aa383a560417efd849c
Autor:
Shiva Kumar Angala, Ana Carreras-Gonzalez, Emilie Huc-Claustre, Itxaso Anso, Devinder Kaur, Victoria Jones, Zuzana Palčeková, Juan M. Belardinelli, Célia de Sousa-d’Auria, Libin Shi, Nawel Slama, Christine Houssin, Annaïk Quémard, Michael McNeil, Marcelo E. Guerin, Mary Jackson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract We report on the existence of two phosphatidic acid biosynthetic pathways in mycobacteria, a classical one wherein the acylation of the sn-1 position of glycerol-3-phosphate (G3P) precedes that of sn-2 and another wherein acylations proceed
Externí odkaz:
https://doaj.org/article/e654bf1aa0a4424ea44490ddc8479d50
Autor:
Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/788b328ee3d0461e94235c15cafbf14f
Autor:
Itxaso Anso, Andreas Naegeli, Javier O. Cifuente, Ane Orrantia, Erica Andersson, Olatz Zenarruzabeitia, Alicia Moraleda-Montoya, Mikel García-Alija, Francisco Corzana, Rafael A. Del Orbe, Francisco Borrego, Beatriz Trastoy, Jonathan Sjögren, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
People with the rare Bombay-type Oh blood group can only be transfused with Oh blood. Here, the authors characterize a bacterial α−1,2-fucosidase that can convert universal O type into rare Bombay type blood.
Externí odkaz:
https://doaj.org/article/db7a4022d6174f63b45084dd7dd3a544
Autor:
Beatriz Trastoy, Jonathan J. Du, Javier O. Cifuente, Lorena Rudolph, Mikel García-Alija, Erik H. Klontz, Daniel Deredge, Nazneen Sultana, Chau G. Huynh, Maria W. Flowers, Chao Li, Diego E. Sastre, Lai-Xi Wang, Francisco Corzana, Alvaro Mallagaray, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Here, the authors establish the mechanisms of recognition and specific deglycosylation of IgG antibodies by
Externí odkaz:
https://doaj.org/article/7aed46f3a16540f68a93f7c72eef2df7
Autor:
Xu Han, Cecilia D'Angelo, Ainara Otamendi, Javier O. Cifuente, Elisa de Astigarraga, Borja Ochoa-Lizarralde, Martin Grininger, Francoise H. Routier, Marcelo E. Guerin, Jana Fuehring, Oier Etxebeste, Sean R. Connell
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Invasive aspergillosis is one of the most serious clinical invasive fungal infections, resulting in a high case fatality rate among immunocompromised patients. The disease is caused by saprophytic molds in the genus Aspergillus, including As
Externí odkaz:
https://doaj.org/article/232e426a0a684ce694dd55e5be755b6b
Autor:
Mikel García-Alija, Jonathan J. Du, Izaskun Ordóñez, Asier Diz-Vallenilla, Alicia Moraleda-Montoya, Nazneen Sultana, Chau G. Huynh, Chao Li, Thomas Connor Donahue, Lai-Xi Wang, Beatriz Trastoy, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
EndoE is a multi-domain glycoside hydrolase of the human pathogen Enterococcus faecalis. Here, the authors present crystal structures of EndoE and provide biochemical insights into the molecular basis of EndoE’s substrate specificity and catalytic
Externí odkaz:
https://doaj.org/article/db42ad5c6c87426d8b470e8e6d00b296
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
OgpA is an O-glycopeptidase from Akkermansia muciniphila, a mucin-degrading bacterium commonly found in the human gut. A thorough characterization of OgpA, including crystal structures in complex with substrate or product, reveals molecular basis of
Externí odkaz:
https://doaj.org/article/ae698bd6443d4047a42023b094a28689
Autor:
Beatriz Trastoy, Jonathan J. Du, Erik H. Klontz, Chao Li, Javier O. Cifuente, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Human gut bacteria depolymerize glycans into their sugar components, which otherwise cannot be processed by their host. Here, the authors characterise the endo-β-N-acetylglucosaminidase EndoBT-3987 from the Gram-negative symbiont Bacteroides thetaio
Externí odkaz:
https://doaj.org/article/0967fd4440514038b204e0c6670b530c