Zobrazeno 1 - 10
of 574
pro vyhledávání: '"E Girardin"'
Autor:
Justin J. Meade, Sarah Stuart, Jana Neiman-Zenevich, Christian Krustev, Stephen E. Girardin, Jeremy Mogridge
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Cleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome. We reported previously
Externí odkaz:
https://doaj.org/article/f8ab6aaf55e6414db21260c2820487f1
Autor:
Paul Y. Bi, Samuel A. Killackey, Linus Schweizer, Damien Arnoult, Dana J. Philpott, Stephen E. Girardin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies performed using epitope-tagged DELE1 showed
Externí odkaz:
https://doaj.org/article/2c938dc33b884251b8cbcb518cef007c
Publikováno v:
Biomedical Journal, Vol 47, Iss 1, Pp 100635- (2024)
NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting conditions. Over the past fifteen years, NLRX1 has been proposed to r
Externí odkaz:
https://doaj.org/article/7b83b3daae22408cb5c490b114c21e9a
Autor:
Ye Liu, Lotte Kors, Loes M. Butter, Geurt Stokman, Nike Claessen, Coert J. Zuurbier, Stephen E. Girardin, Jaklien C. Leemans, Sandrine Florquin, Alessandra Tammaro
Publikováno v:
Cells, Vol 13, Iss 1, p 23 (2023)
Background: Chronic kidney disease often leads to kidney dysfunction due to renal fibrosis, regardless of the initial cause of kidney damage. Macrophages are crucial players in the progression of renal fibrosis as they stimulate inflammation, activat
Externí odkaz:
https://doaj.org/article/a19ace71ab7e4aec9b0f3be9ba50d498
Autor:
Derek K.L. Tsang, Ryan J. Wang, Oliver De Sa, Arshad Ayyaz, Elisabeth G. Foerster, Giuliano Bayer, Shawn Goyal, Daniel Trcka, Bibaswan Ghoshal, Jeffrey L. Wrana, Stephen E. Girardin, Dana J. Philpott
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The small intestinal epithelial barrier inputs signals from the gut microbiota in order to balance physiological inflammation and tolerance, and to promote homeostasis. Understanding the dynamic relationship between microbes and intestinal epithelial
Externí odkaz:
https://doaj.org/article/0018c12ca633427895fd121a96234369
Autor:
Parastoo Boroumand, David C Prescott, Tapas Mukherjee, Philip J Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam, Nancy Shi, Lucie Y Zhu, Zhi Liu, Clinton Robbins, Dana J Philpott, Stephen E Girardin, Amira Klip
Publikováno v:
eLife, Vol 11 (2022)
During obesity and high fat-diet (HFD) feeding in mice, sustained low-grade inflammation includes not only increased pro-inflammatory macrophages in the expanding adipose tissue, but also bone marrow (BM) production of invasive Ly6Chigh monocytes. As
Externí odkaz:
https://doaj.org/article/f814826c238d44d7839ebe163a29ca19
Publikováno v:
BioTechniques, Vol 69, Iss 4, Pp 249-256 (2020)
Mitophagy is the process by which mitochondria are selectively targeted and removed via autophagic machinery to maintain mitochondrial homeostasis in the cell. Recently, flow cytometry-based assays that utilize the fluorescent mtKeima reporter system
Externí odkaz:
https://doaj.org/article/e22e909199ca4fd4a0f1d086eeefbedc
Autor:
Agustina Lavagna, Jean-Philippe Auger, Audrey Dumesnil, David Roy, Stephen E. Girardin, Nicolas Gisch, Mariela Segura, Marcelo Gottschalk
Publikováno v:
Veterinary Research, Vol 50, Iss 1, Pp 1-18 (2019)
Abstract Streptococcus suis serotype 2 is an important porcine pathogen and zoonotic agent causing sudden death, septic shock and meningitis, with exacerbated inflammation being a hallmark of the infection. A rapid, effective and balanced innate immu
Externí odkaz:
https://doaj.org/article/94c60523550a4e51b26b1e6199f5f215
Autor:
Elisabeth G. Foerster, Derek K.L. Tsang, Shawn Goyal, Susan J. Robertson, Lukian M. Robert, Heather Maughan, Catherine J. Streutker, Stephen E. Girardin, Dana J. Philpott
Publikováno v:
Mucosal Immunology. 16:135-152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::315f6e63d72436e9f078caf8a8a95d9e
https://doi.org/10.1016/j.mucimm.2023.02.001
https://doi.org/10.1016/j.mucimm.2023.02.001
Publikováno v:
Kidney International Reports, Vol 6, Iss 4, Pp S336-S337 (2021)
Externí odkaz:
https://doaj.org/article/20f7add4e4324677b35fc7d6fb8c993f