Zobrazeno 1 - 10
of 249
pro vyhledávání: '"E Giese"'
Autor:
Olga Ponomarova, Hefei Zhang, Xuhang Li, Shivani Nanda, Thomas B Leland, Bennett W Fox, Alyxandra N Starbard, Gabrielle E Giese, Frank C Schroeder, L Safak Yilmaz, Albertha J M Walhout
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002057 (2023)
In humans, mutations in D-2-hydroxyglutarate (D-2HG) dehydrogenase (D2HGDH) result in D-2HG accumulation, delayed development, seizures, and ataxia. While the mechanisms of 2HG-associated diseases have been studied extensively, the endogenous metabol
Externí odkaz:
https://doaj.org/article/8eb43474349b438fb9ef2191ac40b72a
Autor:
Sushila Bhattacharya, Brent B. Horowitz, Jingyan Zhang, Xuhang Li, Hefei Zhang, Gabrielle E. Giese, Amy D. Holdorf, Albertha J.M. Walhout
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104688- (2022)
Summary: Metabolic perturbations can affect gene expression, for instance to rewire metabolism. While numerous efforts have measured gene expression in response to individual metabolic perturbations, methods that determine all metabolic perturbations
Externí odkaz:
https://doaj.org/article/443f8aa45de94d38ac828bb72962ec9d
Autor:
Gabrielle E Giese, Melissa D Walker, Olga Ponomarova, Hefei Zhang, Xuhang Li, Gregory Minevich, Albertha JM Walhout
Publikováno v:
eLife, Vol 9 (2020)
Vitamin B12 is an essential micronutrient that functions in two metabolic pathways: the canonical propionate breakdown pathway and the methionine/S-adenosylmethionine (Met/SAM) cycle. In Caenorhabditis elegans, low vitamin B12, or genetic perturbatio
Externí odkaz:
https://doaj.org/article/5f1a40e24054414b90fb5d3766931b07
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3126-3133 (2018)
Summary: Vitamin B12 functions as a cofactor for methionine synthase to produce the anabolic methyl donor S-adenosylmethionine (SAM) and for methylmalonyl-CoA mutase to catabolize the short-chain fatty acid propionate. In the nematode Caenorhabditis
Externí odkaz:
https://doaj.org/article/e60df80979df4c66a450ec60732dc225
Autor:
Bennett W. Fox, Olga Ponomarova, Yong-Uk Lee, Gaotian Zhang, Gabrielle E. Giese, Melissa Walker, Nicole M. Roberto, Huimin Na, Pedro R. Rodrigues, Brian J. Curtis, Aiden R. Kolodziej, Timothy A. Crombie, Stefan Zdraljevic, L. Safak Yilmaz, Erik C. Andersen, Frank C. Schroeder, Albertha J. M. Walhout
Publikováno v:
Nature
Individuals can exhibit differences in metabolism caused by the interplay of genetic background, nutritional input, microbiota, and other environmental factors(1–4). It is difficult to connect differences in metabolism to genomic variation and deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4791629000b75a3618f4be8f39a75c46
https://doi.org/10.1038/s41586-022-04951-3
https://doi.org/10.1038/s41586-022-04951-3
Autor:
Jote T. Bulcha, Gabrielle E. Giese, Md. Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, Albertha J.M. Walhout
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 460-468.e4 (2019)
Summary: Biological systems must possess mechanisms that prevent inappropriate responses to spurious environmental inputs. Caenorhabditis elegans has two breakdown pathways for the short-chain fatty acid propionate: a canonical, vitamin B12-dependent
Externí odkaz:
https://doaj.org/article/f885682baa464efda4376d890475dca9
Akademický článek
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Autor:
Olga Ponomarova, Hefei Zhang, Xuhang Li, Shivani Nanda, Thomas B. Leland, Bennett W. Fox, Gabrielle E. Giese, Frank C. Schroeder, L. Safak Yilmaz, Albertha J.M. Walhout
SUMMARYIn humans, mutations in D-2-hydroxyglutarate (D-2HG) dehydrogenase (D2HGDH) result in D-2HG accumulation, delayed development, seizures, and ataxia. While the mechanisms of 2HG-associated diseases have been studied extensively, the endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cd6e9ff31ca1215d374f324a7e64232
https://doi.org/10.1101/2022.05.16.492161
https://doi.org/10.1101/2022.05.16.492161
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.