Zobrazeno 1 - 10 of 22 pro vyhledávání: '"E G Hanania"'
1
Addition of the Human Interferon β Scaffold Attachment Region to Retroviral Vector Backbones Increases the Level ofin VivoTransgene Expression among Progeny of Engrafted Human Hematopoietic Stem Cells
Autor: L J Murray, Beth L Hill, Marilyn Travis, Ivan Plavec, E. G. Hanania, Katherine Olsson, Karin Luens-Abitorabi, Sean P. Forestell
Publikováno v: Human Gene Therapy. 11:2039-2050
Absence of durable high-level expression of transgenes from Moloney murine leukemia (Mo-MuLV) retroviral vectors has been a hurdle in bringing effective gene therapy to the clinic. In this study we have analyzed transgene expression among the progeny
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdde188ed50cfefad9eef640e4b1f1dd
https://doi.org/10.1089/10430340050143453
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2
Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma
Autor: Philippe Mazars, Mauricette Michallet, Gilles Salles, Anne Thiebaut, Denis Fiere, Tom Leemhuis, Kerry Atkinson, Eric Archimbaud, Hubert Godinot, Christopher L. Reading, Francis Lopez, Gilbert Fine, Bertrand Coiffier, Catherine Sebban, Chris Juttner, Pierre Biron, Nora Roubi, Irène Philip, E. G. Hanania, Thierry Philip
Publikováno v: Experimental Hematology. 28:858-870
Objective The aims of our study performed in myeloma were to evaluate the performance and the safety of Systemix's high-speed clinical cell sorter, to assess the safety and efficacy of de-escalating cell dose cohorts of CD34 + Thy1 + hematopoietic st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e187931d43e4a16173f3677dd2eec9a
https://doi.org/10.1016/s0301-472x(00)00169-7
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3
Real-time t(11;14) and t(14;18) PCR assays provide sensitive and quantitative assessments of minimal residual disease (MRD)
Autor: C Reading, R Ramanathan, C J Gerard, James L. Zehnder, E G Hanania, Carol D. Jones, K Olsson
Publikováno v: Leukemia. 13:1833-1842
Non-Hodgkin's lymphoma (NHL) arises as a clonal transformation of normal B and T cell differentiation and is often characterized by a higher incidence of specific chromosomal translocations. We have developed real-time TaqMan PCR assays directed towa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5557ccb2e532ac7ff11bac8fed9c40b
https://doi.org/10.1038/sj.leu.2401575
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6
Improved quantitation of minimal residual disease in multiple myeloma using real-time polymerase chain reaction and plasmid-DNA complementarity determining region III standards
Autor: C J, Gerard, K, Olsson, R, Ramanathan, C, Reading, E G, Hanania
Publikováno v: Cancer research. 58(17)
The complementarity determining region III of the rearranged immunoglobulin heavy chain gene has been the target for tumor-specific PCR assays for the detection and follow-up of B-cell malignancies. Previously, these assays have relied on gel-based e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0f5d060417fbc79b465f6c1c21f5f74
https://pubmed.ncbi.nlm.nih.gov/9731509
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7
Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation
Autor: L. H. Yin, E. G. Hanania, Albert B. Deisseroth, J. J. Leffert, J. H. Won, Ronald G. Crystal, Giuseppe Pizzorno, R. E. Giles, Richard J. Cote, Barbara Burtness, J. Liang, W. L. Wang, T. Nanakorn, X. Y. Peng, E. Adams, Matthew R. Cooperberg, Siqing Fu, R. Brown, F. Garcia-Sanchez, D. S. Krause
Publikováno v: Blood, vol 92, iss 2
Scopus-Elsevier
Garcia-Sanchez, F; Pizzorno, G; Fu, SQ; Nanakorn, T; Krause, DS; Liang, J; et al.(1998). Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: A potential purging method for autologous transplantation. Blood, 92(2), 672-682. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6g53q4pc
Europe PubMed Central
Ad.CMV-CD is a replication incompetent adenoviral vector carrying a cytomegalovirus (CMV)-driven transcription unit of the cytosine deaminase (CD) gene. The CD transcription unit in this vector catalyzes the deamination of the nontoxic pro-drug, 5-fl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6388da6c2c80507a405e675624d3028
https://escholarship.org/uc/item/6g53q4pc
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8
Simultaneous genetic chemoprotection of normal marrow cells and genetic chemosensitization of breast cancer cells in a mouse cancer gene therapy model
Autor: E G, Hanania, A B, Deisseroth
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(2)
Repeated exposures to high doses of chemotherapy are often required to eradicate solid tumors. The success of such high-dose therapy is often limited by the myelosuppressive and toxic effects of these drugs on bone marrow cells and by the intrinsic r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a5ead07651e19fe6e70c134ce783cba
https://pubmed.ncbi.nlm.nih.gov/9815684
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9
Regulation of retinoblastoma gene expression in a mouse mammary tumor model
Autor: E G, Hanania, W W, Au, R L, Ullrich, J, Papaconstantinou
Publikováno v: Cancer gene therapy. 2(4)
We initiated studies to investigate the involvement of the murine retinoblastoma (RB) gene in mammary carcinogenesis using cell lines derived from mammary glands of irradiated mice. We found that the RB mRNA levels as well as the amounts of the nucle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7aba26ed85970c7ccba432d773e0e364
https://pubmed.ncbi.nlm.nih.gov/8548579
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10
Recent advances in the application of gene therapy to human disease
Autor: Albert B. Deisseroth, R. E. Giles, John J. Kavanagh, Gabriel N. Hortobagyi, E. G. Hanania, Richard E. Champlin
Publikováno v: The American journal of medicine. 99(5)
PURPOSE : To review the recent advances in the application of genetic modification strategies to the therapy of human diseases for which a molecular defect is known. METHODS : A computerized data bank search, the minutes of the National Institutes of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea1317ff34907d124360fd4c4f5b285
https://pubmed.ncbi.nlm.nih.gov/7485213
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