Výsledky vyhledávání

Autor: Alasdair D, Henry, N, MacQuaide, F L, Burton, A C, Rankin, E G, Rowan, R M, Drummond

Publikováno v: Cell calcium. 76

The pulmonary veins have an external sleeve of cardiomyocytes that are a widely recognised source of ectopic electrical activity that can lead to atrial fibrillation. Although the mechanisms behind this activity are currently unknown, changes in intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3946ed8afe4c161c170c56c698106a0
https://pubmed.ncbi.nlm.nih.gov/30253263

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Dataset on the kinetics of the inhibition of PTP1B by the flavonoids and pheophytin A from

Autor: D G, Semaan, J O, Igoli, L, Young, E, Marrero, A I, Gray, E G, Rowan

Publikováno v: Data in Brief

The data presented in this article are related to the research article under the title “in vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw. on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes” (Semaa

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https://pubmed.ncbi.nlm.nih.gov/29876409

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Snake Venom Phospholipases A2: A Novel Tool Against Bacterial Diseases

Autor: R. P. Samy, P. Gopalakrishnakone, B. G. Stiles, K. S. Girish, S. N. Swamy, M. Hemshekhar, K. S. Tan, E. G. Rowan, G. Sethi, V. T.K. Chow

Publikováno v: Current Medicinal Chemistry. 19:6150-6162

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43e3b6533940453dafba661484dd9cda
https://doi.org/10.2174/0929867311209066150

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Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity

Autor: N, Alessandri-Haber, A, Lecoq, S, Gasparini, G, Grangier-Macmath, G, Jacquet, A L, Harvey, C, de Medeiros, E G, Rowan, M, Gola, A, Ménez, M, Crest

Publikováno v: The Journal of biological chemistry. 274(50)

BgK is a peptide from the sea anemone Bunodosoma granulifera, which blocks Kv1.1, Kv1.2, and Kv1.3 potassium channels. Using 25 analogs substituted at a single position by an alanine residue, we performed the complete mapping of the BgK binding sites

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https://pubmed.ncbi.nlm.nih.gov/10585444

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Delineation of the functional site of alpha-dendrotoxin. The functional topographies of dendrotoxins are different but share a conserved core with those of other Kv1 potassium channel-blocking toxins

Autor: S, Gasparini, J M, Danse, A, Lecoq, S, Pinkasfeld, S, Zinn-Justin, L C, Young, C C, de Medeiros, E G, Rowan, A L, Harvey, A, Ménez

Publikováno v: The Journal of biological chemistry. 273(39)

We identified the residues that are important for the binding of alpha-dendrotoxin (alphaDTX) to Kv1 potassium channels on rat brain synaptosomal membranes, using a mutational approach based on site-directed mutagenesis and chemical synthesis. Twenty

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https://pubmed.ncbi.nlm.nih.gov/9738007

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On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures

Autor: M, Dauplais, A, Lecoq, J, Song, J, Cotton, N, Jamin, B, Gilquin, C, Roumestand, C, Vita, C L, de Medeiros, E G, Rowan, A L, Harvey, A, Ménez

Publikováno v: The Journal of biological chemistry. 272(7)

BgK is a K+ channel-blocking toxin from the sea anemone Bunodosoma granulifera. It is a 37-residue protein that adopts a novel fold, as determined by NMR and modeling. An alanine-scanning-based analysis revealed the functional importance of five resi

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https://pubmed.ncbi.nlm.nih.gov/9020148

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Toxins affecting K+ channels

Autor: E G, Rowan, A L, Harvey

Publikováno v: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 29(12)

Potassium channels are involved in modulating the excitability of neurones by regulating the membrane potential, or by affecting the amount of neurotransmitter released from nerve terminals. Potassium channels are highly diverse and can be activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ee891f83ef39340c672188e2567ec64
https://pubmed.ncbi.nlm.nih.gov/9222442

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Effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents

Autor: A L, Harvey, E G, Rowan

Publikováno v: Advances in neurology. 51

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https://pubmed.ncbi.nlm.nih.gov/2294657

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Akademický článek

Effects of odontobuthus doriae scorpion venom on mouse sciatic nerve.

Autor: Vatanpour H; Full Professor in Pharmacology and Toxicology, Dept. of Pharmacology and Toxicology, Pharmaceutical Research Sciences Center and School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Jalali A, G Rowan E, Rahim F

Publikováno v: Iranian journal of pharmaceutical research : IJPR [Iran J Pharm Res] 2013 Winter; Vol. 12 (Suppl), pp. 145-51.

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