Zobrazeno 1 - 10
of 28
pro vyhledávání: '"E G, Mimnaugh"'
Publikováno v:
Cellular and molecular biology (Noisy-le-Grand, France).
Cisplatin is among the most effective chemotherapeutic agents in the treatment of human ovarian cancer. The cytotoxicity of cisplatin results primarily from its ability to bind covalently to DNA and prevent DNA replication and transcription. The ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca25747f2c9ecbb292ad1818ab4fa593
https://pubmed.ncbi.nlm.nih.gov/11936875
https://pubmed.ncbi.nlm.nih.gov/11936875
Publikováno v:
Electrophoresis. 20(2)
Ubiquitination of key cellular proteins involved in signal transduction, gene transcription and cell-cycle regulation usually condemns those proteins to proteasomal or lysosomal degradation. Additionally, cycles of reversible ubiquitination regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f63c51106c0c3b11add1171ded20e537
https://pubmed.ncbi.nlm.nih.gov/10197449
https://pubmed.ncbi.nlm.nih.gov/10197449
Publikováno v:
Cancer research. 55(20)
Taxol stabilizes microtubules, prevents tubulin depolymerization, and promotes tubulin bundling and is one of the most effective drugs for the treatment of metastatic breast and ovarian cancer. Although its interaction with tubulin has been well char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83ad5d0b1d88541957fbb00ba2d62d94
https://pubmed.ncbi.nlm.nih.gov/7553639
https://pubmed.ncbi.nlm.nih.gov/7553639
We have investigated the antiproliferative effects of recombinant human interleukin-1 alpha (IL-1) combined with the cytotoxic antitumor drug doxorubicin against A375 human melanoma IL-1-sensitive (C6) and IL-1-resistant (C5) clonal cell lines. Growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f014cbd530f4fb66cf3dca2d0c9e0aa4
http://hdl.handle.net/11383/1761833
http://hdl.handle.net/11383/1761833
Publikováno v:
Cancer research. 51(3)
To investigate the possibility that anticancer drugs combined with cytokines may show increased activity, human tumor cells were treated with combinations of human recombinant interleukin 1 alpha (rIL-1 alpha) and etoposide (VP-16). The cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd3940290a41d96b0d070cfdd9859cb9
https://pubmed.ncbi.nlm.nih.gov/1824825
https://pubmed.ncbi.nlm.nih.gov/1824825
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 2(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c360e6b4c988e400695a825efd7b193f
https://pubmed.ncbi.nlm.nih.gov/4152872
https://pubmed.ncbi.nlm.nih.gov/4152872
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 3(4)
Comparative studies of in vitro drug metabolism by hepatic and extrahepatic tissues have been complicated by the use of a single experimental tissue, few animal species, and variable experimental conditions. In an attempt to minimize these complicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3071239e893d3b505ec1b0db4b90ea58
https://pubmed.ncbi.nlm.nih.gov/240655
https://pubmed.ncbi.nlm.nih.gov/240655
Publikováno v:
Biochemical pharmacology. 31(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50632297f29c914ccc764b3004456a82
https://pubmed.ncbi.nlm.nih.gov/6756414
https://pubmed.ncbi.nlm.nih.gov/6756414
Publikováno v:
Cancer research. 44(7)
Rat liver microsomal activation of the anthracycline antitumor drug, Adriamycin, in the presence of reduced pyridine nucleotide under anaerobic conditions produces reactive species that bind covalently to cellular macromolecules including DNA. Since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2532da32592584629659a8e30bb3562
https://pubmed.ncbi.nlm.nih.gov/6327028
https://pubmed.ncbi.nlm.nih.gov/6327028